Zobrazeno 1 - 10
of 197 272
pro vyhledávání: '"Deepak A."'
Autor:
Mehreen Elahee, Alisa A. Mueller, Runci Wang, Kathryne E. Marks, Takanori Sasaki, Ye Cao, Andrea Fava, Paul F. Dellaripa, Francesco Boin, Deepak A. Rao
Publikováno v:
ACR Open Rheumatology, Vol 6, Iss 7, Pp 429-439 (2024)
Objective T cells contribute to tissue injury in systemic sclerosis (SSc), yet the specific T cell subsets expanded in patients with SSc remain incompletely defined. Here we evaluated specific phenotypes and functions of peripheral helper T (Tph) and
Externí odkaz:
https://doaj.org/article/f28238a6fae84f978ff2cf2458dae924
Autor:
Miguel Rodriguez de los Santos, Brian H. Kopell, Ariela Buxbaum Grice, Gauri Ganesh, Andy Yang, Pardis Amini, Lora E. Liharska, Eric Vornholt, John F. Fullard, Pengfei Dong, Eric Park, Sarah Zipkowitz, Deepak A. Kaji, Ryan C. Thompson, Donjing Liu, You Jeong Park, Esther Cheng, Kimia Ziafat, Emily Moya, Brian Fennessy, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Brendan Sullivan, Vanessa Cohen, Prashant Kota, Claudia Feng, Jessica S. Johnson, Marysia-Kolbe Rieder, Joseph Scarpa, Girish N. Nadkarni, Minghui Wang, Bin Zhang, Pamela Sklar, Noam D. Beckmann, Eric E. Schadt, Panos Roussos, Alexander W. Charney, Michael S. Breen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification within the brain. Yet, most research has relied on postmortem samples, assuming it is an accurate representation of RNA biology in the living brain. W
Externí odkaz:
https://doaj.org/article/da9c46017e36443fb5aa615c25a1975d
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Kathryn Weinand, Saori Sakaue, Aparna Nathan, Anna Helena Jonsson, Fan Zhang, Gerald F. M. Watts, Majd Al Suqri, Zhu Zhu, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Deepak A. Rao, Jennifer H. Anolik, Michael B. Brenner, Laura T. Donlin, Kevin Wei, Soumya Raychaudhuri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of the
Externí odkaz:
https://doaj.org/article/6fa32e092ab54daeaadb71dbcca5722d
Autor:
Taehyeung Kim, Marta Martínez-Bonet, Qiang Wang, Nicolaj Hackert, Jeffrey A. Sparks, Yuriy Baglaenko, Byunghee Koh, Roxane Darbousset, Raquel Laza-Briviesca, Xiaoting Chen, Vitor R. C. Aguiar, Darren J. Chiu, Harm-Jan Westra, Maria Gutierrez-Arcelus, Matthew T. Weirauch, Soumya Raychaudhuri, Deepak A. Rao, Peter A. Nigrovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Fine-mapping and functional studies implicate rs117701653, a non-coding single nucleotide polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and type 1 diabetes. Here, using DNA pulldown, mass spectrometry,
Externí odkaz:
https://doaj.org/article/89591f74d78449f789de95d34d7df2b8
Autor:
Praveen Kumar Pasala, Niranjan Kumar Raghupathi, Deepak A. Yaraguppi, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Sheikh F. Ahmad, Yeswanth Chennamsetty, P.V. Kamala Kumari, Prasanth DSNBK
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33154- (2024)
The present study examined the potential neuroprotective effects of aloe-emodin (AE) nanoparticles on the cerebral stroke-associated target protein myeloperoxidase (MPO). We investigated the binding interactions between AE and MPO through molecular d
Externí odkaz:
https://doaj.org/article/b348ca66805840fd9769ec4298f69bde
Autor:
Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, Betty Diamond, Anne Davidson, David Wofsy, Diane Kamen, Judith A. James, Joel M. Guthridge, William Apruzzese, Deepak A. Rao, Michael H. Weisman, The Accelerating Medicines Partnership in RA/SLE Network, Michelle Petri, Jill Buyon, Richard Furie
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus nephritis. Methods Pati
Externí odkaz:
https://doaj.org/article/aa6c6fe2475645d1b8b302bc77c6beb6
Autor:
Santhoshi V. Akkenepally, Dan J. K. Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak A. Deshpande, Francis X. McCormack, Satish K. Madala
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mecha
Externí odkaz:
https://doaj.org/article/afb44756c2a84b2a9424fac53d1b188a
Publikováno v:
American Journal of Perinatology Reports, Vol 14, Iss 02, Pp e162-e169 (2024)
Background Superoxide anions (O2 −) have multiple effects on pulmonary parenchyma altering cell proliferation, cellular metabolism, and airway smooth muscle (ASM) contraction. Intracellular calcium ([Ca2+]i) concentration plays a significant role
Externí odkaz:
https://doaj.org/article/3b02635a616a4a19ad97f0a5afdbf323
Autor:
Partha Saradhi Tallapalli, Yennam Dastagiri Reddy, Deepak A. Yaraguppi, Surya Prabha Matangi, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Sheikh F. Ahmad, Haneen A. Al-Mazroua, Mithun Rudrapal, Prasanth Dintakurthi Sree Naga Bala Krishna, Praveen Kumar Pasala
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1093 (2024)
Objective: This study aimed to compare the effects of β-sitosterol nanoparticles (BETNs) and β-sitosterol (BET) on cognitive impairment, oxidative stress, and inflammation in a myocardial infarction (MI) rat model using in silico and in vivo method
Externí odkaz:
https://doaj.org/article/ea8c6aa805f1409da74eda2dab4c6aa1