Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Deepak A Lamba"'
Autor:
Sangeetha Kandoi, Cassandra Martinez, Kevin Xu Chen, Miika Mehine, L Vinod K Reddy, Brian C Mansfield, Jacque L Duncan, Deepak A Lamba
Publikováno v:
eLife, Vol 12 (2024)
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder, causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO) account for ~25% cases of autosomal dominant RP (adRP). I
Externí odkaz:
https://doaj.org/article/7450c3797a71493d85bdb55da0488e53
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258872 (2021)
Retinal homeostasis relies on intricate coordination of cell death and survival in response to stress and damage. Signaling mechanisms that coordinate this process in the adult retina remain poorly understood. Here we identify Decapentaplegic (Dpp) s
Externí odkaz:
https://doaj.org/article/cfc875bc592f4ed6aa7d7b2b7d68c758
Autor:
Branden R Nelson, Yumi Ueki, Sara Reardon, Mike O Karl, Sean Georgi, Byron H Hartman, Deepak A Lamba, Thomas A Reh
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22817 (2011)
Previous studies have shown that Müller glia are closely related to retinal progenitors; these two cell types express many of the same genes and after damage to the retina, Müller glia can serve as a source for new neurons, particularly in non-mamm
Externí odkaz:
https://doaj.org/article/e5ac9243eca14e74a3cd7a08e853bc23
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8763 (2010)
BackgroundInherited and acquired retinal degenerations are frequent causes of visual impairment and photoreceptor cell replacement therapy may restore visual function to these individuals. To provide a source of new retinal neurons for cell based the
Externí odkaz:
https://doaj.org/article/985078a234eb4cbcaeac81201ba8f71b
Autor:
Peggy Arthur, Sangeetha Kandoi, Li Sun, Anil Kalvala, Shallu Kutlehria, Santanu Bhattacharya, Tanmay Kulkarni, Ramesh Nimma, Yan Li, Deepak A. Lamba, Mandip Singh
Publikováno v:
Pharmaceutical Research. 40:801-816
There is a growing interest in extracellular vesicles (EVs) for ocular applications as therapeutics, biomarkers, and drug delivery vehicles. EVs secreted from mesenchymal stem cells (MSCs) have shown to provide therapeutic benefits in ocular conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7cda808ce30d2fc382eb07cffb7b5b
https://doi.org/10.1007/s11095-022-03350-7
https://doi.org/10.1007/s11095-022-03350-7
Autor:
Sangeetha Kandoi, Cassandra Martinez, Kevin Xu Chen, Brian C. Mansfield, Jacque L. Duncan, Deepak A. Lamba
Retinitis pigmentosa (RP), a heterogenous group of inherited retinal disorder causes slow progressive vision loss with no effective treatments available. Mutations in the rhodopsin gene (RHO), account for ∼40% cases of autosomal dominant RP (adRP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e56507cc70ecab2ff302d9d3a49bddb0
https://doi.org/10.1101/2023.02.27.23286248
https://doi.org/10.1101/2023.02.27.23286248
Publikováno v:
Stem cell reports, vol 16, iss 11
Stem Cell Reports
Stem Cell Reports
Summary Cases of Leber congenital amaurosis caused by mutations in CRX (LCA7) exhibit an early form of the disease and show signs of significant photoreceptor dysfunction and eventual loss. To establish a translational in vitro model system to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88204b16224676ac14706abf8a4b5d3
https://doi.org/10.1016/j.stemcr.2021.09.007
https://doi.org/10.1016/j.stemcr.2021.09.007
Publikováno v:
Vision Research. 209:108257
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25f4d2579f2a4ccf7444862e5d5bd463
https://doi.org/10.1016/j.visres.2023.108257
https://doi.org/10.1016/j.visres.2023.108257
Autor:
Thomas V. Johnson, David J. Calkins, Brad Fortune, Jeffrey L. Goldberg, Anna La Torre, Deepak A. Lamba, Jason S. Meyer, Thomas A. Reh, Valerie A. Wallace, Donald J. Zack, Petr Baranov
Publikováno v:
iScience
Neuronal repopulation achieved through transplantation or transdifferentiation from endogenous sources holds tremendous potential for restoring function in chronic neurodegenerative disease or acute injury. Key to the evaluation of neuronal engraftme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427b4cdd3e88aa4af37fc483182d68de
https://doi.org/10.1016/j.isci.2023.106361
https://doi.org/10.1016/j.isci.2023.106361
Autor:
Vismaya S. Bachu, Sangeetha Kandoi, Ko Uoon Park, Michael L. Kaufman, Michael Schwanke, Deepak A. Lamba, Joseph A. Brzezinski
Publikováno v:
Developmental biology. 488
How cone photoreceptors are formed during retinal development is only partially known. This is in part because we do not fully understand the gene regulatory network responsible for cone genesis. We reasoned that cis-regulatory elements (enhancers) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9684639e3f047f9c3d3fae117396d7a9
https://pubmed.ncbi.nlm.nih.gov/35644251
https://pubmed.ncbi.nlm.nih.gov/35644251