Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Deepak, Kaushal"'
Autor:
Shyamala Thirunavukkarasu, Mushtaq Ahmed, Bruce A. Rosa, Mark Boothby, Sung Hoon Cho, Javier Rangel-Moreno, Stanley K. Mbandi, Valérie Schreiber, Ananya Gupta, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Thomas J. Scriba, Shabaana A. Khader
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
The ADP ribosyltransferases (PARPs 1–17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). Alth
Externí odkaz:
https://doaj.org/article/4c22a3c3f8194eee8454f8a9197e2d78
Autor:
Arshad Khan, Kangling Zhang, Vipul K. Singh, Abhishek Mishra, Priyanka Kachroo, Tian Bing, Jong Hak Won, Arunmani Mani, Ramesha Papanna, Lovepreet K. Mann, Eder Ledezma-Campos, Genesis Aguillon-Duran, David H. Canaday, Sunil A. David, Blanca I. Restrepo, Nhung Nguyen Viet, Ha Phan, Edward A. Graviss, James M. Musser, Deepak Kaushal, Marie Claire Gauduin, Chinnaswamy Jagannath
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
Khan et al. use human blood and a macaque model of tuberculosis (TB) to assess whether macrophage heterogeneity contributes to TB immunity. They demonstrate that human macrophages show unique patterns of gene expression that enable differential contr
Externí odkaz:
https://doaj.org/article/8cf06a1a4f1b42998d5b3586157a23de
Autor:
Dhiraj K. Singh, Ekaterina Aladyeva, Shibali Das, Bindu Singh, Ekaterina Esaulova, Amanda Swain, Mushtaq Ahmed, Journey Cole, Chivonne Moodley, Smriti Mehra, Larry S. Schlesinger, Maxim N. Artyomov, Shabaana A. Khader, Deepak Kaushal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection, Singh et al. provide longitudinal scRNA-Seq of the broncho-alveolar compartment of SARS-CoV-2 infected rhesus macaques. They observe an accumulati
Externí odkaz:
https://doaj.org/article/ae41ab4ead8645a8baa2d47cebcd2017
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1120 (2023)
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in HIV-infected persons, with one in four deaths attributable to TB. While the majority of healthy indiv
Externí odkaz:
https://doaj.org/article/b107b8cff3b440998af90ea7eb5fefca
Autor:
Bindu Singh, Chivonne Moodley, Dhiraj K. Singh, Ruby A. Escobedo, Riti Sharan, Garima Arora, Shashank R. Ganatra, Vinay Shivanna, Olga Gonzalez, Shannan Hall-Ursone, Edward J. Dick Jr., Deepak Kaushal, Xavier Alvarez, Smriti Mehra
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. IDO expressio
Externí odkaz:
https://doaj.org/article/59e3a53626764aa2a1294a8cc4c559ab
Autor:
Edith M. Walker, Kristen M. Merino, Nadia Slisarenko, Brooke F. Grasperge, Smriti Mehra, Chad J. Roy, Deepak Kaushal, Namita Rout
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
BackgroundAlthough BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined correlates of pr
Externí odkaz:
https://doaj.org/article/c94f2b062858405cad2a503cc4deffd7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb infection in
Externí odkaz:
https://doaj.org/article/f576a799959f43c1a05a238f69930f9c
Autor:
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick Jr., Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria in macaques
Externí odkaz:
https://doaj.org/article/659732e8266a421b8e6775d23db444b0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Mycobacterium tuberculosis forms biofilms in vitro, but it is unclear whether biofilms are also formed during infection in vivo. Here, Chakraborty et al. demonstrate the formation of biofilms in animal models of infection and in patients with tubercu
Externí odkaz:
https://doaj.org/article/e6344464f0fb44cfa9b65724b192dc41
Autor:
Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and
Externí odkaz:
https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f