Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Deepak, Bhattarai"'
Autor:
Hirendra Man Pradhan, Sudha Jha, Lalit M Patnaik, Asoke K Talukder, Deepak Bhattarai, S Sitharama Iyenger
Information and communication technology (ICT) has become a generic and indispensable tool for addressing and solving problems in such diverse areas as management, social and health services, transportation, security and education. As the cost of equ
Autor:
Thomas M Lietman, Jeremy D Keenan, Kieran S O'Brien, Travis Porco, Daniel Schwartz, Travis C Porco, Suzanne Gilbert, Valerie M Stevens, Raghunandan Byanju, Ram Prasad Kandel, Gopal Bhandari, Sadhan Bhandari, Jason S Melo, Prakriti Acharaya, Manmohan Adhikari, Shree Kanta Adihikari, Deepak Bhattarai, Rabin Bhattarai, Ajaya Chaudhary, Bhagiram Chaudhary, Daya Shankar Chaudhary, Kishor Chaudhary, Krishna Raj Dharel, Maria Gautam, Shree Krishna Gautam, Aakriti Ghimire, Bishwash Ghimire, Narayan Ghimire, Ramesh Ghimire, Gaurav Giri, Puspa Giri, Dhanmaya Gurau, Ramesh Gurung, Deepak Kandel, Simanta Khadka, Benju Lamichhane, Pappu Mahato, Pratikshya Neupane, Ram Janaki Panday, Sabina Parajuli, Radhika Devi Poudel, Susmita Poudel, Sangita Pradhan, Suchan Pun, Bishaka Ranabhat, Sudha Ranabhat, Gaurav Rimal, Gopal Sapkota, Subit Sapkota, Ranjeet Shah, Manisha Shrestha, Saraswati Silwal, Amisha Subedi, Pradeep Subedi, Alish Tamang, Dilip Tandukar, Nischal Sharma Wagle, Nilam Kumari Yadav, Sailesh Mishra, Heidi Chase, Lauren Jesudason, Chundak Tenzing, Shravan Chaudhary, Parami Dhakwha, Prasanna Sharma, Apsara Shrestha, Jeremy Keenan, Thomas Lietman, Jason Melo, Kieran O’Brien, Riju Shrestha, Robert Stamper, Valerie Stevens
Publikováno v:
BMJ Open, Vol 10, Iss 10 (2020)
Introduction The majority of blindness worldwide could be prevented or reversed with early diagnosis and treatment, yet identifying at-risk and prevalent cases of eye disease and linking them with care remain important obstacles to addressing this bu
Externí odkaz:
https://doaj.org/article/3e1e8c652344411d9329b63f80061fb0
Autor:
Ji Eun Park, Deepak Bhattarai, Yujin Park, Min Jae Lee, Sumin Son, Dong‐Eun Kim, Kyung Bo Kim
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb6ca85eb1ae1f431a39cd29fa7ad07
https://doi.org/10.1002/alz.064511
https://doi.org/10.1002/alz.064511
Autor:
Zachary Miller, In Jun Yeo, Deepak Bhattarai, Ahruem Baek, Sukyeong Lee, Yu Mi Baek, Min Jae Lee, Kyung Bo Kim, Jin Tae Hong, Dong-Eun Kim
Publikováno v:
Journal of Medicinal Chemistry. 63:3763-3783
The immunoproteasome (iP), an inducible proteasome variant harboring three immunosubunits, low molecular mass polypeptide-2 (LMP2), multicatalytic endopeptidase complex subunit-1, and low molecular mass polypeptide-7 (LMP7), is involved in multiple f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc5ecae9140a15dfc6b3ab0fa2955e3
https://doi.org/10.1021/acs.jmedchem.0c00416
https://doi.org/10.1021/acs.jmedchem.0c00416
Autor:
Hoi Kyoung Kim, Myung Hee Kim, Minkyoung Kim, Won Suk Yang, Hye Young Cho, Aneesh Sivaraman, Jihye Lee, Semi Lim, Youngjin Lee, Young Ho Jeon, Kyeong Lee, Ameeq Ul Mushtaq, Deepak Bhattarai, Dae Gyu Kim, Younah Roh, Se Young Son, Sunghoon Kim
Publikováno v:
Nature Chemical Biology. 16:31-41
A tumorigenic factor, AIMP2 lacking exon 2 (AIMP2-DX2), is often upregulated in many cancers. However, how its cellular level is determined is not understood. Here, we report heat-shock protein HSP70 as a critical determinant for the level of AIMP2-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2051a4bea5ec2df591dd741b027a8065
https://doi.org/10.1038/s41589-019-0415-2
https://doi.org/10.1038/s41589-019-0415-2
Autor:
Shuichiro Hirahara, Tetsuro Oshika, Siddharth Narendran, J. Ignacio Aguirre, Shinichi Fukuda, Meenakshi Ambati, Benjamin J. Fowler, Praveen Yerramothu, Bradley D. Gelfand, David R. Hinton, Jayakrishna Ambati, Gerald G. Schumann, Ulrike Held, Yosuke Nagasaka, Felipe Pereira, Kirstie Baker, Nagaraj Kerur, Srinivas R. Sadda, Sanford H. Feldman, Shaobin Wang, Akhil Varshney, Peirong Huang, Ryan D. Makin, Kameshwari Ambati, Vera L. Bonilha, Mo Wang, Tetsuhiro Yasuma, Reo Yasuma, Vidya L. Ambati, Elmira Baghdasaryan, Xiwen Huang, Hiroko Terasaki, Daipayan Banerjee, Ivana Apicella, Kenneth M. Marion, Genrich V. Tolstonog, Yuichiro Ogura, Deepak Bhattarai, Kyung Bo Kim
Publikováno v:
Science advances, 7(40):eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Description
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76950f2faadbc056f974ac06c1a507
https://doi.org/10.1126/sciadv.abj3658
https://doi.org/10.1126/sciadv.abj3658
Autor:
Kyung Bo Kim, Jin Tae Hong, Min Jae Lee, Deepak Bhattarai, Wooin Lee, Ahreum Baek, Zachary Miller, In Jun Yeo, Seongsoo Lee, Hyeryung Jang, Sukyeong Lee, Dong-Eun Kim
Publikováno v:
Journal of medicinal chemistry. 64(15)
Previously, we reported that immunoproteasome (iP)-targeting linear peptide epoxyketones improve cognitive function in mouse models of Alzheimer's disease (AD) in a manner independent of amyloid β. However, these compounds' clinical prospect for AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8735e13c838c2757166a299160cff34
https://pubmed.ncbi.nlm.nih.gov/34309393
https://pubmed.ncbi.nlm.nih.gov/34309393
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The second-in-class proteasome inhibitor (PI) carfilzomib (Kyprolis, Cfz) has contributed to a substantial advancement in multiple myeloma treatment by improving patient survival and quality of life. A considerable portion of patients however display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b4355dff6d7ea00bbc7d981eb1005e
http://link.springer.com/article/10.1038/s41598-019-40635-1
http://link.springer.com/article/10.1038/s41598-019-40635-1
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab56470358e690f442ac6be149dcb9
https://doi.org/10.1073/pnas.2022751118
https://doi.org/10.1073/pnas.2022751118