Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Deepa Rajagopal"'
Autor:
Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J. Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pa
Externí odkaz:
https://doaj.org/article/0bdbc34a3c9f4aa9acf1c9f0c03b6ceb
Autor:
Jantipa Jobsri, Alex Allen, Deepa Rajagopal, Michael Shipton, Kostya Kanyuka, George P Lomonossoff, Christian Ottensmeier, Sandra S Diebold, Freda K Stevenson, Natalia Savelyeva
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118096 (2015)
Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic
Externí odkaz:
https://doaj.org/article/47ed0c9573c541e4ad1d874e2b4b03b2
Autor:
Jiwon Yang, Jing Jiao, Kyle M. Draheim, Guoxiang Yang, Hongyuan Yang, Li‐Chin Yao, Leonard D. Shultz, Dale L. Greiner, Deepa Rajagopal, Sandrine Vessillier, Curtis C. Maier, Sunish Mohanan, Danying Cai, Mingshan Cheng, Michael A. Brehm, James G. Keck
Publikováno v:
The FASEB Journal. 37
Autor:
Mohammad Amin Honardoost, Andreas Adinatha, Florian Schmidt, Bobby Ranjan, Maryam Ghaeidamini, Nirmala Arul Rayan, Michelle Gek Liang Lim, Ignasius Joanito, Quy Xiao Xuan Lin, Deepa Rajagopalan, Shi Qi Mok, You Yi Hwang, Anis Larbi, Chiea Chuen Khor, Roger Foo, Bernhard Otto Boehm, Shyam Prabhakar
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting $$\beta$$ β cells. A comprehensive immune cell phenotype evaluation in T1D
Externí odkaz:
https://doaj.org/article/c994264bbf6c46a98457293f3fbf1308
Autor:
Quy Xiao Xuan Lin, Deepa Rajagopalan, Akshamal M. Gamage, Le Min Tan, Prasanna Nori Venkatesh, Wharton O. Y. Chan, Dilip Kumar, Ragini Agrawal, Yao Chen, Siew-Wai Fong, Amit Singh, Louisa J. Sun, Seow-Yen Tan, Louis Yi Ann Chai, Jyoti Somani, Bernett Lee, Laurent Renia, Lisa F P Ng, Kollengode Ramanathan, Lin-Fa Wang, Barnaby Young, David Lye, Amit Singhal, Shyam Prabhakar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Due to the paucity of longitudinal molecular studies of COVID-19, particularly those covering the early stages of infection (Days 1-8 symptom onset), our understanding of host response over the disease course is limited. We perform longitudi
Externí odkaz:
https://doaj.org/article/9f2600a9ca174e47b4b821252b56c6f1
Autor:
Dexter Kai Hao Thng, Lissa Hooi, Clarissa Chin Min Toh, Jhin Jieh Lim, Deepa Rajagopalan, Imran Qamar Charles Syariff, Zher Min Tan, Masturah Bte Mohd Abdul Rashid, Lei Zhou, Alfred Wei Chieh Kow, Glenn Kunnath Bonney, Brian Kim Poh Goh, Juinn Huar Kam, Sudhakar Jha, Yock Young Dan, Pierce Kah Hoe Chow, Tan Boon Toh, Edward Kai‐Hua Chow
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2275-2294 (2023)
Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone‐lysine N‐methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including
Externí odkaz:
https://doaj.org/article/626aaf793fd742a0bc57798a71194ba1
Autor:
Lili Wang, Deepa Rajagopal, Linhua Tian, Luisa Saraiva, Shiqiu Xiong, Sandrine Vessillier, Jonathan Campbell
Publikováno v:
J Immunol Regen Med
Accurate determination of cellular subsets that secrete particular cytokine(s) is a significant parameter for functional characterization of an immunological response. The present study was conducted to develop a method for simultaneous measurement o
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 364:605-611
Somatic hypermutation of immunoglobulin (Ig) genes occurs at a frequency that is a million times greater than the mutation in other genes. Mutations occur in variable genes to increase antibody affinity, and in switch regions before constant genes to
Publikováno v:
European Journal of Immunology. 36:828-841
The heat shock protein (HSP) Hsp90 is known to chaperone cytosolic peptides for MHC class I (MHCI)-restricted antigen presentation to T lymphocytes. We now demonstrate a role for Hsp90 activity in presentation of antigens on MHCII. Treatment of mouse
Publikováno v:
Nature Immunology. 6:287-294
By convention, presentation of major histocompatibility complex (MHC) class I-restricted epitopes involves processing by cytosolic proteasomes, whereas MHC class II-restricted epitopes are generated by endosomal proteases. Here, we show that two MHC