Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Deepa R. Jamwal"'
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Akademický článek
Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells
Autor: Vanessa Figliuolo da Paz, Deepa R. Jamwal, Michael Gurney, Monica Midura-Kiela, Christy A. Harrison, Christopher Cox, Jean M. Wilson, Fayez K. Ghishan, Pawel R. Kiela
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Dendritic cells (DCs) are pivotal in regulating tolerogenic as well as immunogenic responses against microorganisms by directing both the innate and adaptive immune response. In health, phenotypically different DC subsets found in the gut mucosa are
Externí odkaz: https://doaj.org/article/d3a88fdf2d3342bbb87717a836fc1653
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2
ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges
Autor: Chyi S. Hsieh, Pawel R. Kiela, Sytse J. Piersma, Wayne M. Yokoyama, Deepta Bhattacharya, Deepa R. Jamwal, You W. Zhou, Arijita Jash, Diana K. Gerardo, Bijal A. Parikh, Tyler J. Ripperger, Adrianus C. M. Boon
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
ZBTB32 is a transcription factor that is highly expressed by a subset of memory B cells and restrains the magnitude and duration of recall responses against hapten-protein conjugates. To define physiological contexts in which ZBTB32 acts, we assessed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972713a25336787daee4b7e0698c7096
http://link.springer.com/article/10.1038/s41598-019-51860-z
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3
Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell–Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction
Autor: Raji V Marati, Monica T. Midura-Kiela, David G. Besselsen, Fayez K. Ghishan, Pawel R. Kiela, Deepa R. Jamwal, Vanessa R Figliuolo Paz, Christy A. Harrison
Publikováno v: Inflamm Bowel Dis
Background Inflammatory bowel disease (IBD) is a multifactorial disorder, with the innate and adaptive immune cells contributing to disease initiation and progression. However, the intricate cross-talk between immune cell lineages remains incompletel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef66ceae595536c57c9b6d2499593173
https://doi.org/10.1093/ibd/izz191
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4
Intestinal Regulatory T Cells
Autor: Vanessa Figliuolo da Paz, Deepa R. Jamwal, Pawel R. Kiela
Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9789811564062
Adv Exp Med Biol
Mucosal surfaces are distinctive sites exposed to environmental, dietary, and microbial antigens. Particularly in the gut, the host continuously actively adapts via complex interactions between the microbiota and dietary compounds and immune and othe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd12d2a23a732a016a41989a289a7fc
https://doi.org/10.1007/978-981-15-6407-9_9
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5
Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis
Autor: Daniel Laubitz, Deepa R. Jamwal, Pawel R. Kiela, Monica T. Midura-Kiela, Fayez K. Ghishan, Christy A. Harrison, David G. Besselsen
Publikováno v: Journal of Crohn's and Colitis. 13:115-126
Background Broad-spectrum antibiotics [Abx], including combination therapy with ciprofloxacin and metronidazole, are often prescribed during the treatment of inflammatory bowel disease [IBD] to alleviate symptoms, but with varying success. In this pi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fda2ae3c3b7dbfbf636fa295d6949cb
https://doi.org/10.1093/ecco-jcc/jjy144
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6
Microbial Dysbiosis Associated with Impaired Intestinal Na+/H+ Exchange Accelerates and Exacerbates Colitis in Ex-Germ Free Mice
Autor: Christy A. Harrison, Fayez K. Ghishan, Pawel R. Kiela, Deepa R. Jamwal, Christina L. Ohland, Daniel Laubitz, Christian Jobin, Monica T. Midura-Kiela, David G. Besselsen, Karuna Patil
Publikováno v: Mucosal immunology
Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3fa33768de5c8aeefa2483cbdd85a6
http://europepmc.org/articles/PMC6162102
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7
Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice
Autor: Pawel R. Kiela, Deepa R. Jamwal, Daniel Laubitz, Fayez K. Ghishan, Claire B. Larmonier, Kareem W. Shehab
Publikováno v: Journal of Biological Chemistry. 291:8918-8930
Poly(ADP-ribose) polymerases (PARPs) synthesize and bind branched polymers of ADP-ribose to acceptor proteins using NAD as a substrate and participate in the control of gene transcription and DNA repair. PARP1, the most abundant isoform, regulates th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f14441568c66ae1b2881d81373de48e
https://doi.org/10.1074/jbc.m116.714386
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