Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Deepa K. Rungta"'
Autor:
Yanping Xu, Mary K. Peters, Brian A. Oldham, Sarah B. Wilson, Aaron Kunkel, Allie Edward Tripp, Minmin Wang, Robert E. Babine, Leonard L. Winneroski, Richard W. Zink, Robert J. Ardecky, Deepa K. Rungta, Mccarthy James R, Garret J. Etgen, Christopher John Rito, D. R. Hutchison, Dawn A. Brooks, Dale E. Mais, Raymond F. Kauffman, Kathleen M. Ogilvie, Chahrzad Montrose-Rafizadeh
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(24)
To understand the species selectivity in a series of alpha-methyl-alpha-phenoxy carboxylic acid PPARalpha/gamma dual agonists (1-11), structure-based molecular modeling was carried out in the ligand binding pockets of both human and mouse PPARalpha.
Autor:
Yanping, Xu, Christopher J, Rito, Garret J, Etgen, Robert J, Ardecky, James S, Bean, William R, Bensch, Jacob R, Bosley, Carol L, Broderick, Dawn A, Brooks, Samuel J, Dominianni, Patric J, Hahn, Sha, Liu, Dale E, Mais, Chahrzad, Montrose-Rafizadeh, Kathy M, Ogilvie, Brian A, Oldham, Mary, Peters, Deepa K, Rungta, Anthony J, Shuker, Gregory A, Stephenson, Allie E, Tripp, Sarah B, Wilson, Leonard L, Winneroski, Richard, Zink, Raymond F, Kauffman, James R, McCarthy
Publikováno v:
Journal of medicinal chemistry. 47(10)
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) alpha/gamma agonist (S)-2-methyl-3-[4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl]-2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and
Autor:
John S. Tyhonas, R. Ajamie, R.A. Ardecky, Michael Gregory Bell, Christopher M. Mapes, Timothy Alan Grese, D.L. Gernert, Pierre-Yves Michellys, D.A. Mais, Nathan Yumibe, Deepa K. Rungta, Anne Reifel-Miller, Mark D. Leibowitz
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(19)
Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRalpha and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the positi