Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Deepa K. Machiah"'
Autor:
Juan M. Peralta, Diane M. Warren, Stephen T. Warren, Tom E. Howard, Sandra G. Porter, John Blangero, Juan Carlos Souto, Todd M. Smith, Alfonso Buil, Karl Fernstrom, Jordi Fontcuberta, Manana Khachidze, Kevin R. Viel, Deepa K. Machiah, Laura Almasy, José Manuel Soria, W. Dana Flanders
Publikováno v:
Blood. 109:3713-3724
Plasma factor VIII coagulant activity (FVIII:C) level is a highly heritable quantitative trait that is strongly correlated with thrombosis risk. Polymorphisms within only 1 gene, the ABO blood-group locus, have been unequivocally demonstrated to cont
Autor:
Karl Fernstrom, Tom E. Howard, Afshin Ameri, Deepa K. Machiah, Cynthia Channell, Thuy Tran, Valerie Crenshaw, Sebastien Fuchs, Alexander Duncan, Manana Khachidze
Publikováno v:
Thrombosis and Haemostasis. 98:1165-1169
SummaryWe identified a previously unknown mutation by sequencing the factor (F)X gene in a severely haemorrhagic 14-year-old maleAfrican-American individual with undetectable plasma FX-activity and -antigen levels. This mutation, called F10-Augusta,
Autor:
Bannikuppe S. Vishwanath, S. Nagaraju, M. Vedavathi, Kesturu S. Girish, K. Harish Kumar, S. Ushanandini, Kempaiah Kemparaju, Deepa K. Machiah, T. V. Gowda
Publikováno v:
Phytotherapy Research. 20:851-858
In Indian traditional medicine, various plants have been used widely as a remedy for treating snake bites. The aim of this study was to evaluate the effect of Tamarindus indica seed extract on the pharmacological as well as the enzymatic effects indu
Autor:
Manana Khachidze, Laura Almasy, Kevin R. Viel, J. C. Souto, José Manuel Soria, Tom E. Howard, Stephen T. Warren, Deepa K. Machiah, Mark Lathrop, Alfonso Buil, Diane M. Warren, Afshin Ameri, John Blangero, Jordi Fontcuberta, Sandra G. Porter
Publikováno v:
Journal of Thrombosis and Haemostasis. 4:1537-1545
Summary. Background: High-normal and elevated plasma FIX activity (FIX:C) levels are associated with increased risk for venous- and possibly arterial-thrombosis. Objective: Because the broad normal range for FIX:C involves a substantial unknown genet
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 143(2)
Venom hyaluronidases help in rapid spreading of the toxins by destroying the integrity of the extra-cellular matrix of the tissues in the victims. A hyaluronidase inhibitor (WSG) is purified from a folk medicinal plant, Withania somnifera. The glycop
Publikováno v:
Biochimie. 88(6)
A post-synaptic neurotoxic phospholipase A(2) (PLA(2)) has been purified from Indian cobra Naja naja venom. It was associated with a peptide in the venom. The association was disrupted using 8 M urea. It is denoted to be a basic protein by its behavi
Autor:
Raymond G. Watts, Rathi V. Iyer, Kevin R. Viel, Cynthia Channel, Joanna A. Davis, Charles L. Lutcher, Tom E. Howard, Laura Almasy, Deepa K. Machiah, Afshin Ameri, Thomas C. Abshire
Publikováno v:
Blood. 106:3207-3207
The development of neutralizing antibodies against plasma-derived or recombinant (r) molecules of wildtype (wt) factor (F)VIII protein is the most serious complication of replacement therapy for hemophilia A (hA) patients. Although the pathogenesis o
Autor:
Afshin Ameri, Cynthia Channell, Tom E. Howard, Darlene Livingston, Deepa K. Machiah, Kristen L. Toren, Valerie Crenshaw, Thuy Tran
Publikováno v:
Blood. 104:1045-1045
Due to its position in the coagulation cascade, factor X (fX), a circulating zymogen is activated during hemostatic challenges to its serine protease fXa first via the extrinsic pathway’s tissue factor/factor VIIa complex and next by the intrinsic