Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Deepa K Murugesh"'
Publikováno v:
JBMR Plus, Vol 7, Iss 8, Pp n/a-n/a (2023)
ABSTRACT Post traumatic osteoarthritis (PTOA) is a form of secondary osteoarthritis (OA) that develops in ~50% of cases of severe articular joint injuries and leads to chronic and progressive degradation of articular cartilage and other joint tissues
Externí odkaz:
https://doaj.org/article/b37e7ffbb8014fad819f0e3a0cb6d3b8
Autor:
Sarah V. Mendoza, Deepa K. Murugesh, Blaine A. Christiansen, Zoe O. Genetos, Gabriela G. Loots, Damian C. Genetos, Clare E. Yellowley
Publikováno v:
JBMR Plus, Vol 7, Iss 4, Pp n/a-n/a (2023)
ABSTRACT Molecular oxygen levels vary during development and disease. Adaptations to decreased oxygen bioavailability (hypoxia) are mediated by hypoxia‐inducible factor (HIF) transcription factors. HIFs are composed of an oxygen‐dependent α subu
Externí odkaz:
https://doaj.org/article/745d2379944a48efb944772743c74359
Autor:
Aimy Sebastian, Nicholas R. Hum, Jillian L. McCool, Stephen P. Wilson, Deepa K. Murugesh, Kelly A. Martin, Naiomy Deliz Rios-Arce, Beheshta Amiri, Blaine A. Christiansen, Gabriela G. Loots
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide. Accumulating evidence attests to the important roles of the immune system in OA pathogenesis. Understanding the role of various immune cells in joint
Externí odkaz:
https://doaj.org/article/f300656bbb3c4474aac3fe6b2c690ffd
Autor:
Naiomy D Rios‐Arce, Deepa K Murugesh, Nicholas R Hum, Aimy Sebastian, Elias H Jbeily, Blaine A Christiansen, Gabriela G Loots
Publikováno v:
JBMR Plus, Vol 6, Iss 5, Pp n/a-n/a (2022)
ABSTRACT Type 1 diabetes mellitus (T1DM) affects 9.5% of the population. T1DM is characterized by severe insulin deficiency that causes hyperglycemia and leads to several systemic effects. T1DM has been suggested as a risk factor for articular cartil
Externí odkaz:
https://doaj.org/article/c3e2d3a89854486ebd278c4d6385c2e3
Autor:
Edmond Y. Lau, Oscar A. Negrete, W. F. Drew Bennett, Brian J. Bennion, Monica Borucki, Feliza Bourguet, Aidan Epstein, Magdalena Franco, Brooke Harmon, Stewart He, Derek Jones, Hyojin Kim, Daniel Kirshner, Victoria Lao, Jacky Lo, Kevin McLoughlin, Richard Mosesso, Deepa K. Murugesh, Edwin A. Saada, Brent Segelke, Maxwell A. Stefan, Garrett A. Stevenson, Marisa W. Torres, Dina R. Weilhammer, Sergio Wong, Yue Yang, Adam Zemla, Xiaohua Zhang, Fangqiang Zhu, Jonathan E. Allen, Felice C. Lightstone
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
A rapid response is necessary to contain emergent biological outbreaks before they can become pandemics. The novel coronavirus (SARS-CoV-2) that causes COVID-19 was first reported in December of 2019 in Wuhan, China and reached most corners of the gl
Externí odkaz:
https://doaj.org/article/d413250ed30f441981cd5475fb7487b8
Autor:
Cristine Donham, Betsabel Chicana, Alexander G. Robling, Asmaa Mohamed, Sonny Elizaldi, Michael Chi, Brian Freeman, Alberto Millan, Deepa K. Murugesh, Nicholas R. Hum, Aimy Sebastian, Gabriela G. Loots, Jennifer O. Manilay
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9111 (2021)
Romosozumab, a humanized monoclonal antibody specific for sclerostin (SOST), has been approved for treatment of postmenopausal women with osteoporosis at a high risk for fracture. Previous work in sclerostin global knockout (Sost−/−) mice indicat
Externí odkaz:
https://doaj.org/article/2173d4e5546a446f900c9a3ac0b323e6
Publikováno v:
JBMR Plus.
Autor:
Aimy Sebastian, Jillian L. McCool, Nicholas R. Hum, Deepa K. Murugesh, Stephen P. Wilson, Blaine A. Christiansen, Gabriela G. Loots
Publikováno v:
Cells, Vol 10, Iss 6, p 1462 (2021)
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally. The articular cartilage is co
Externí odkaz:
https://doaj.org/article/184fda9e21d64e4394383875302472bc
Autor:
Sarah V. Mendoza, Deepa K. Murugesh, Blaine A. Christiansen, Zoe O. Genetos, Gabriela G. Loots, Damian C. Genetos, Clare E. Yellowley
Publikováno v:
JBMR Plus. 7