Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Deepa, Sampath"'
Autor:
Janani Ravikrishnan, Daisy Y. Diaz-Rohena, Elizabeth Muhowski, Xiaokui Mo, Tzung-Huei Lai, Shrilekha Misra, Charmelle D. Williams, John Sanchez, Andrew Mitchell, Suresh Satpati, Elizabeth Perry, Tierney Kaufman, Chaomei Liu, Arletta Lozanski, Gerard Lozanski, KerryA Rogers, Adam S. Kittai, Seema A. Bhat, Mary C. Collins, Matthew S. Davids, Nitin Jain, William G. Wierda, Rosa Lapalombella, John C. Byrd, Fenlai Tan, Yi Chen, Yu Chen, Yue Shen, Stephen P. Anthony, Jennifer A. Woyach, Deepa Sampath
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Patients with chronic lymphocytic leukemia (CLL) respond well to initial treatment with the Bcell lymphoma 2 (BCL2) inhibitor venetoclax. Upon relapse, they often retain sensitivity to BCL2 targeting, but durability of response remains a concern. We
Externí odkaz:
https://doaj.org/article/84739096159249b4b8f8ad48426936e4
Autor:
Elizabeth M. Muhowski, Janani Ravikrishnan, Britten Gordon, Lianbo Yu, Shrilekha Misra, Brandi Walker, Sudharshan Eathiraj, Deepa Sampath, Kerry A. Rogers, John C. Byrd, Jennifer A. Woyach
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Inhibitors of B cell receptor (BCR) signaling such as the Bruton’s tyrosine kinase (BTK) inhibitors are effective therapeutics for chronic lymphocytic leukemia (CLL). The first-in-class covalent BTK inhibitor, ibrutinib, produces durable r
Externí odkaz:
https://doaj.org/article/cbd3349984cb4091abe926011ab6ccf0
Autor:
Shaneice Mitchell, Pu Zhang, Matthew Cannon, Larry Beaver, Amy Lehman, Bonnie Harrington, Deepa Sampath, John C. Byrd, Rosa Lapalombella
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract KPT-9274 is a phase 1 first-in-class dual PAK4/NAMPT inhibitor for solid tumor and non-Hodgkin’s lymphoma. It demonstrates pre-clinical efficacy toward a broad spectrum of acute myeloid leukemia (AML) subtypes by inhibiting NAMPT-dependent
Externí odkaz:
https://doaj.org/article/fe02419664a049739c44ce0e6885ce29
Autor:
Timothy L. Chen, Bonnie Harrington, Jean Truxall, Ronni Wasmuth, Alexander Prouty, Shelby Sloan, Amy M. Lehman, Deepa Sampath, Eric Orlemans, Robert A. Baiocchi, Lapo Alinari, John C. Byrd, Jennifer A. Woyach, Erin Hertlein
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract B-cell receptor (BCR) antagonists such as the BTK inhibitor ibrutinib have proven to effectively target chronic lymphocytic leukemia (CLL) tumor cells, leading to impressive response rates in these patients. However patients do still relapse
Externí odkaz:
https://doaj.org/article/4c01d238e7a84a94ba1ec2e43998f4b6
Autor:
Steven Sher, Ethan Whipp, Janek Walker, Pu Zhang, Larry Beaver, Katie Williams, Shelley Orwick, Janani Ravikrishnan, Brandi Walker, Elizabeth Perry, Charles Gregory, Matthew Purcell, Alexander Pan, Pearlly Yan, Lapo Alinari, Amy J. Johnson, Melanie M. Frigault, Joy M. Greer, Ahmed Hamdy, Raquel Izumi, Xiaokui Mo, Deepa Sampath, Jennifer Woyach, James Blachly, John C. Byrd, Rosa Lapalombella
Publikováno v:
Leukemia. 37:326-338
Chronic lymphocytic leukemia (CLL) is effectively treated with targeted therapies including Bruton tyrosine kinase inhibitors and BCL2 antagonists. When these become ineffective, treatment options are limited. Positive transcription elongation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a868428a2ac8c2b3894afc9dce8d9d
https://doi.org/10.1038/s41375-022-01758-z
https://doi.org/10.1038/s41375-022-01758-z
Autor:
Max Yano, Chia Sharpe, J. Rachel Lance, Janani Ravikrishnan, Kevan Zapolnik, Xiaokui Mo, Jennifer A. Woyach, Deepa Sampath, Adam S. Kittai, Sumithira Vasu, Seema Bhat, Kerry A. Rogers, Dean A. Lee, Natarajan Muthusamy, John C. Byrd
Publikováno v:
Blood Advances. 6:5641-5654
Successes with anti-CD20 antibodies in chronic lymphocytic leukemia (CLL) and enhanced activity of Fc-engineered vs unmodified antibody therapy suggest a potentially impactful role for natural killer (NK) cells and other innate immune cells in contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff7d9c8eee3c64f177101fec5cc3cd6
https://doi.org/10.1182/bloodadvances.2021005883
https://doi.org/10.1182/bloodadvances.2021005883
Autor:
Jennifer A. Woyach, John C. Byrd, Amy J. Johnson, Brian Schwartz, Giovanni Abbadessa, Sudharshan Eathiraj, Rosa Lapalombella, Deepa Sampath, Amy M. Lehman, Leslie Andritsos, Kami Maddocks, Farrukh T. Awan, Kerry A. Rogers, Bonnie K. Harrington, Minh Tran, Virginia M. Goettl, Catherine A. Fabian, Elizabeth M. Muhowski, J.T. Greene, Lisa L. Smith, Rose Mantel, Sean D. Reiff
methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7ef9f6bcdee97cb0b821e7d945632a
https://doi.org/10.1158/2159-8290.22531706
https://doi.org/10.1158/2159-8290.22531706
Autor:
Jennifer A. Woyach, John C. Byrd, Amy J. Johnson, Brian Schwartz, Giovanni Abbadessa, Sudharshan Eathiraj, Rosa Lapalombella, Deepa Sampath, Amy M. Lehman, Leslie Andritsos, Kami Maddocks, Farrukh T. Awan, Kerry A. Rogers, Bonnie K. Harrington, Minh Tran, Virginia M. Goettl, Catherine A. Fabian, Elizabeth M. Muhowski, J.T. Greene, Lisa L. Smith, Rose Mantel, Sean D. Reiff
Suppl Figure 2 with legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385f18aeea68dabb4dbbaac94338f38c
https://doi.org/10.1158/2159-8290.22531715.v1
https://doi.org/10.1158/2159-8290.22531715.v1
Autor:
Jennifer A. Woyach, John C. Byrd, Amy J. Johnson, Brian Schwartz, Giovanni Abbadessa, Sudharshan Eathiraj, Rosa Lapalombella, Deepa Sampath, Amy M. Lehman, Leslie Andritsos, Kami Maddocks, Farrukh T. Awan, Kerry A. Rogers, Bonnie K. Harrington, Minh Tran, Virginia M. Goettl, Catherine A. Fabian, Elizabeth M. Muhowski, J.T. Greene, Lisa L. Smith, Rose Mantel, Sean D. Reiff
Suppl Table 2 with legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0535de0493bbdaa7fa5937f5929b5676
https://doi.org/10.1158/2159-8290.22531709
https://doi.org/10.1158/2159-8290.22531709
Autor:
Jennifer A. Woyach, John C. Byrd, Amy J. Johnson, Brian Schwartz, Giovanni Abbadessa, Sudharshan Eathiraj, Rosa Lapalombella, Deepa Sampath, Amy M. Lehman, Leslie Andritsos, Kami Maddocks, Farrukh T. Awan, Kerry A. Rogers, Bonnie K. Harrington, Minh Tran, Virginia M. Goettl, Catherine A. Fabian, Elizabeth M. Muhowski, J.T. Greene, Lisa L. Smith, Rose Mantel, Sean D. Reiff
Suppl Table 1 with legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3f15fd95f429da4a0774e78dceb823
https://doi.org/10.1158/2159-8290.22531712
https://doi.org/10.1158/2159-8290.22531712