Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Deep Upadhyay"'
Autor:
Melissa L. Abel, Nobuyuki Takahashi, Cody Peer, Christophe E. Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Sunmin Lee, Meenakshi Shelat, Robbie Kattappuram, Linda Sciuto, Danielle Pinkiert, Chante Graham, Donna Butcher, Baktiar Karim, Ajit Kumar Sharma, Justin Malin, Rajesh Kumar, Christopher W. Schultz, Shubhank Goyal, Jaydira del Rivero, Manan Krishnamurthy, Deep Upadhyay, Brett Schroeder, Tristan Sissung, Manoj Tyagi, Jung Kim, Yves Pommier, Mirit Aladjem, Mark Raffeld, William Douglas Figg, Jane Trepel, Liqiang Xi, Parth Desai, Anish Thomas
Publikováno v:
Clinical Cancer Research. :OF1-OF9
Purpose: Despite promising preclinical studies, toxicities have precluded combinations of chemotherapy and DNA damage response (DDR) inhibitors. We hypothesized that tumor-targeted chemotherapy delivery might enable clinical translation of such combi
Autor:
Lőrinc Sándor Pongor, Christopher W. Schultz, Lorenzo Rinaldi, Darawalee Wangsa, Christophe E. Redon, Nobuyuki Takahashi, Gavriel Fialkoff, Parth Desai, Yang Zhang, Sandra Burkett, Nadav Hermoni, Noa Vilk, Jenia Gutin, Rona Gergely, Yongmei Zhao, Samantha Nichols, Rasa Vilimas, Linda Sciuto, Chante Graham, Juan Manuel Caravaca, Sevilay Turan, Shen Tsai-wei, Vinodh N. Rajapakse, Rajesh Kumar, Deep Upadhyay, Suresh Kumar, Yoo Sun Kim, Nitin Roper, Bao Tran, Stephen M. Hewitt, David E. Kleiner, Mirit I. Aladjem, Nir Friedman, Gordon L. Hager, Yves Pommier, Thomas Ried, Anish Thomas
Publikováno v:
Cancer Discovery. 13:928-949
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. Oncogenic MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC amplification and phenotypic plasticity, characterized by neuroendocrine and nonneuroe
Autor:
Anish Thomas, Parth Desai, Liqiang Xi, Jane Trepel, William Douglas Figg, Mark Raffeld, Mirit Aladjem, Yves Pommier, Jung Kim, Manoj Tyagi, Tristan Sissung, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Jaydira del Rivero, Shubhank Goyal, Christopher W. Schultz, Rajesh Kumar, Justin Malin, Ajit Kumar Sharma, Baktiar Karim, Donna Butcher, Chante Graham, Danielle Pinkiert, Linda Sciuto, Robbie Kattappuram, Meenakshi Shelat, Sunmin Lee, Min-Jung Lee, Rasa Vilimas, Samantha Nichols, Christophe E. Redon, Cody Peer, Nobuyuki Takahashi, Melissa L. Abel
Study Representativeness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1134469c3d0836c8a00a656b51d038b1
https://doi.org/10.1158/1078-0432.23183836
https://doi.org/10.1158/1078-0432.23183836
Autor:
Anish Thomas, Parth Desai, Liqiang Xi, Jane Trepel, William Douglas Figg, Mark Raffeld, Mirit Aladjem, Yves Pommier, Jung Kim, Manoj Tyagi, Tristan Sissung, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Jaydira del Rivero, Shubhank Goyal, Christopher W. Schultz, Rajesh Kumar, Justin Malin, Ajit Kumar Sharma, Baktiar Karim, Donna Butcher, Chante Graham, Danielle Pinkiert, Linda Sciuto, Robbie Kattappuram, Meenakshi Shelat, Sunmin Lee, Min-Jung Lee, Rasa Vilimas, Samantha Nichols, Christophe E. Redon, Cody Peer, Nobuyuki Takahashi, Melissa L. Abel
Pharmacokinetic assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06619753b143d9112a4bb0c3cb9b8e1
https://doi.org/10.1158/1078-0432.23183851.v1
https://doi.org/10.1158/1078-0432.23183851.v1
Autor:
Anish Thomas, Parth Desai, Liqiang Xi, Jane Trepel, William Douglas Figg, Mark Raffeld, Mirit Aladjem, Yves Pommier, Jung Kim, Manoj Tyagi, Tristan Sissung, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Jaydira del Rivero, Shubhank Goyal, Christopher W. Schultz, Rajesh Kumar, Justin Malin, Ajit Kumar Sharma, Baktiar Karim, Donna Butcher, Chante Graham, Danielle Pinkiert, Linda Sciuto, Robbie Kattappuram, Meenakshi Shelat, Sunmin Lee, Min-Jung Lee, Rasa Vilimas, Samantha Nichols, Christophe E. Redon, Cody Peer, Nobuyuki Takahashi, Melissa L. Abel
Trial protocol dose limiting toxicity criteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719d1224a7d725404c43187779ea8040
https://doi.org/10.1158/1078-0432.23183857.v1
https://doi.org/10.1158/1078-0432.23183857.v1
Autor:
Anish Thomas, Parth Desai, Liqiang Xi, Jane Trepel, William Douglas Figg, Mark Raffeld, Mirit Aladjem, Yves Pommier, Jung Kim, Manoj Tyagi, Tristan Sissung, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Jaydira del Rivero, Shubhank Goyal, Christopher W. Schultz, Rajesh Kumar, Justin Malin, Ajit Kumar Sharma, Baktiar Karim, Donna Butcher, Chante Graham, Danielle Pinkiert, Linda Sciuto, Robbie Kattappuram, Meenakshi Shelat, Sunmin Lee, Min-Jung Lee, Rasa Vilimas, Samantha Nichols, Christophe E. Redon, Cody Peer, Nobuyuki Takahashi, Melissa L. Abel
Purpose:Despite promising preclinical studies, toxicities have precluded combinations of chemotherapy and DNA damage response (DDR) inhibitors. We hypothesized that tumor-targeted chemotherapy delivery might enable clinical translation of such combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7577de8e937edbaabfad8bf2398a84
https://doi.org/10.1158/1078-0432.c.6664579.v1
https://doi.org/10.1158/1078-0432.c.6664579.v1
Autor:
Anish Thomas, Thomas Ried, Yves Pommier, Gordon L. Hager, Nir Friedman, Mirit I. Aladjem, David E. Kleiner, Stephen M. Hewitt, Bao Tran, Nitin Roper, Yoo Sun Kim, Suresh Kumar, Deep Upadhyay, Rajesh Kumar, Vinodh N. Rajapakse, Shen Tsai-wei, Sevilay Turan, Juan Manuel Caravaca, Chante Graham, Linda Sciuto, Rasa Vilimas, Samantha Nichols, Yongmei Zhao, Rona Gergely, Jenia Gutin, Noa Vilk, Nadav Hermoni, Sandra Burkett, Yang Zhang, Parth Desai, Gavriel Fialkoff, Nobuyuki Takahashi, Christophe E. Redon, Darawalee Wangsa, Lorenzo Rinaldi, Christopher W. Schultz, Lőrinc Sándor Pongor
ecDNA in SCLC, related to Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc364e23dd8ec76bf9c7c808ebeba99
https://doi.org/10.1158/2159-8290.22553442
https://doi.org/10.1158/2159-8290.22553442
Autor:
Anish Thomas, Thomas Ried, Yves Pommier, Gordon L. Hager, Nir Friedman, Mirit I. Aladjem, David E. Kleiner, Stephen M. Hewitt, Bao Tran, Nitin Roper, Yoo Sun Kim, Suresh Kumar, Deep Upadhyay, Rajesh Kumar, Vinodh N. Rajapakse, Shen Tsai-wei, Sevilay Turan, Juan Manuel Caravaca, Chante Graham, Linda Sciuto, Rasa Vilimas, Samantha Nichols, Yongmei Zhao, Rona Gergely, Jenia Gutin, Noa Vilk, Nadav Hermoni, Sandra Burkett, Yang Zhang, Parth Desai, Gavriel Fialkoff, Nobuyuki Takahashi, Christophe E. Redon, Darawalee Wangsa, Lorenzo Rinaldi, Christopher W. Schultz, Lőrinc Sándor Pongor
Enhancer-enhancer interaction results of MYC and MYCL ecDNAs in the DMS-273 cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade2d2222ae80c0ff9384da09bf24578
https://doi.org/10.1158/2159-8290.22553409.v1
https://doi.org/10.1158/2159-8290.22553409.v1
Autor:
Anish Thomas, Thomas Ried, Yves Pommier, Gordon L. Hager, Nir Friedman, Mirit I. Aladjem, David E. Kleiner, Stephen M. Hewitt, Bao Tran, Nitin Roper, Yoo Sun Kim, Suresh Kumar, Deep Upadhyay, Rajesh Kumar, Vinodh N. Rajapakse, Shen Tsai-wei, Sevilay Turan, Juan Manuel Caravaca, Chante Graham, Linda Sciuto, Rasa Vilimas, Samantha Nichols, Yongmei Zhao, Rona Gergely, Jenia Gutin, Noa Vilk, Nadav Hermoni, Sandra Burkett, Yang Zhang, Parth Desai, Gavriel Fialkoff, Nobuyuki Takahashi, Christophe E. Redon, Darawalee Wangsa, Lorenzo Rinaldi, Christopher W. Schultz, Lőrinc Sándor Pongor
Small-cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. Oncogenic MYC amplifications drive SCLC heterogeneity, but the genetic mechanisms of MYC amplification and phenotypic plasticity, characterized by neuroendocrine and nonneuroe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de78f78b54345017eb684fdc765dadc
https://doi.org/10.1158/2159-8290.c.6534631.v2
https://doi.org/10.1158/2159-8290.c.6534631.v2
Autor:
Anish Thomas, Thomas Ried, Yves Pommier, Gordon L. Hager, Nir Friedman, Mirit I. Aladjem, David E. Kleiner, Stephen M. Hewitt, Bao Tran, Nitin Roper, Yoo Sun Kim, Suresh Kumar, Deep Upadhyay, Rajesh Kumar, Vinodh N. Rajapakse, Shen Tsai-wei, Sevilay Turan, Juan Manuel Caravaca, Chante Graham, Linda Sciuto, Rasa Vilimas, Samantha Nichols, Yongmei Zhao, Rona Gergely, Jenia Gutin, Noa Vilk, Nadav Hermoni, Sandra Burkett, Yang Zhang, Parth Desai, Gavriel Fialkoff, Nobuyuki Takahashi, Christophe E. Redon, Darawalee Wangsa, Lorenzo Rinaldi, Christopher W. Schultz, Lőrinc Sándor Pongor
Cell line AmpliconArchitect assemblies, related to figure 1 and Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947c9b4d275cf163c9e83691d9b152e8
https://doi.org/10.1158/2159-8290.22494856
https://doi.org/10.1158/2159-8290.22494856