Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Deep Pokharel"'
Autor:
Deep Pokharel, Matthew P. Padula, Jamie F. Lu, Jessica L. Tacchi, Frederick Luk, Steven P. Djordjevic, Mary Bebawy
Publikováno v:
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-10 (2014)
Cancer multidrug resistance (MDR) occurs when cancer cells evade the cytotoxic actions of chemotherapeutics through the active efflux of drugs from within the cells. Our group have previously demonstrated that multidrug-resistant breast cancer cells
Externí odkaz:
https://doaj.org/article/a24743d45d1d45a2862ab3acd80acbe8
Autor:
Deep Pokharel, Matthew P. Padula, Jamie F. Lu, Ritu Jaiswal, Steven P. Djordjevic, Mary Bebawy
Publikováno v:
Molecules, Vol 21, Iss 3, p 290 (2016)
Multidrug resistance (MDR) is often attributed to the over-expression of P-glycoprotein (P-gp), which prevents the accumulation of anticancer drugs within cells by virtue of its active drug efflux capacity. We have previously described the intercellu
Externí odkaz:
https://doaj.org/article/eedad103e4014c6d8ae0950321dd1678
Publikováno v:
ecancermedicalscience
© the authors; Chemotherapy is an essential part of anticancer treatment. However, the overexpression of P-glycoprotein (P-gp) and the subsequent emergence of multidrug resistance (MDR) hampers successful treatment clinically. P-gp is a multidrug ef
Publikováno v:
Drug delivery and translational research. 7(2)
© 2016, Controlled Release Society. P-glycoprotein (P-gp/ABCB1) and multidrug resistance-associated protein 1 (MRP1/ABCC1) are the main drug efflux transporters associated with treatment failure in cancer. Much attention has been focused on the mole
Autor:
David D. Sampson, Brendan F. Kennedy, Philip Wijesinghe, Mary Bebawy, Vincent P. Wallace, Deep Pokharel, Jamie F. Lu, Vici Oenarto
Publikováno v:
Omics : a journal of integrative biology. 20(8)
Deciphering the role of cell-to-cell communication in acquisition of cancer traits such as metastasis is one of the key challenges of integrative biology and clinical oncology. In this context, extracellular vesicles (EVs) are important vectors in ce
Publikováno v:
Journal of biochemistry. 160(5)
© 2016 The Authors. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved. Microvesicles (MVs) serve as vectors of nucleic-acid dissemination and are important mediators of intercellular communicatio
Autor:
Mary Bebawy, Steven P. Djordjevic, Deep Pokharel, Ritu Jaiswal, Jamie F. Lu, Matthew P. Padula
Publikováno v:
Molecules
Molecules, Vol 21, Iss 3, p 290 (2016)
Molecules; Volume 21; Issue 3; Pages: 290
Molecules, Vol 21, Iss 3, p 290 (2016)
Molecules; Volume 21; Issue 3; Pages: 290
© 2016 by the authors. Multidrug resistance (MDR) is often attributed to the over-expression of P-glycoprotein (P-gp), which prevents the accumulation of anticancer drugs within cells by virtue of its active drug efflux capacity. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba965ddc5646573fd74e99a32dc610db
https://hdl.handle.net/10453/43767
https://hdl.handle.net/10453/43767
Publikováno v:
Drug metabolism reviews. 47(4)
© 2015 Taylor & Francis. The phenomenon of multidrug resistance (MDR) in cancer is associated with the overexpression of the ATP-binding cassette (ABC) transporter proteins, including multidrug resistance-associated protein 1 (MRP1) and P-glycoprote
Publikováno v:
Cancer Research. 76:5114-5114
Cell to cell communication is vital for the co-ordination of physiological process and the regulation of an organism's phenotype. More recently communication via extracellular membrane vesicles has gained recognition. We first described a novel mecha
Publikováno v:
Nanomedicine : nanotechnology, biology, and medicine. 9(3)
Gold nanoparticles (AuNPs) have been widely investigated as potential nanocarriers for drug delivery. In the present study, AuNPs were conjugated to a peptide that has a C-terminal Lys–Asp–Glu–Leu (KDEL) motif. In a pulse-chase study, time-cour