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pro vyhledávání: '"Deena Rennerfeldt"'
Autor:
Fiore Cattaruzza, Ayesha Nazeer, Milton To, Mikhail Hammond, Caitlin Koski, Lucas Liu, V. Pete Yeung, Deena Rennerfeldt, Angela Henkensiefken, Michael Fox, Sharon Lam, Kari Morrissey, Zachary Lange, Vladimir Podust, Mika Derynck, Bryan Irving, Volker Schellenberger
To enhance the therapeutic index of T-cell engagers (TCE), we engineered masked, conditionally active TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 [HER2] or epidermal growth factor receptor 2 [EGFR]) and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9fbef64ebfb9ce12787efd733daeaf5
https://doi.org/10.21203/rs.3.rs-2045998/v1
https://doi.org/10.21203/rs.3.rs-2045998/v1
Autor:
Milton To, Pete Yeung, Michael Fox, Mikhail Hammond, Fiore Cattaruzza, Ayesha Nazeer, Caitlin Koski, Lucas Liu, Sina Khorsand, Deena Rennerfeldt, Kari Morrissey, Zachary Lange, Ming Dong, Sharon Lam, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger
Publikováno v:
Molecular Cancer Therapeutics. 20:P193-P193
Background: TCEs are effective in leukemias, but have been limited in solid tumors due to on-target, off-tumor toxicity. Attempts to circumvent cytokine release syndrome (CRS), including step-up dosing and complex designs, have had limited success du