Výsledky vyhledávání - "Deena Ream-Robinson"

Akademický článek

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

Autor: Barbara Jung, Jessica Gomez, Eddy Chau, Jennifer Cabral, Jeffrey K Lee, Aimee Anselm, Przemyslaw Slowik, Deena Ream-Robinson, Karen Messer, Judith Sporn, Sung K Shin, C Richard Boland, Ajay Goel, John M Carethers

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8308 (2009)

Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cance

Externí odkaz: https://doaj.org/article/1bc4d553f83f4d61b04c961514c99c7d

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Akademický článek

Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair.

Autor: Heekyung Chung, Dennis J Young, Claudia G Lopez, Thuy-Anh T Le, Jeffrey K Lee, Deena Ream-Robinson, Sherry C Huang, John M Carethers

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3463 (2008)

Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFbeta family receptors is abr

Externí odkaz: https://doaj.org/article/27f6e1c85a4d4529b5e913814679c85f

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Flanking sequence specificity determines coding microsatellite heteroduplex and mutation rates with defective DNA mismatch repair (MMR)

Autor: Claudia G. Lopez, Deena Ream-Robinson, Joy Holmstrom, Dennis J. Young, Heekyung Chung, John M. Carethers, Betty L. Cabrera, Jenny F. Lai

Publikováno v: Oncogene

The activin type II receptor (ACVR2) contains two identical microsatellites in exons 3 and 10, but only the exon 10 microsatellite is frameshifted in mismatch repair (MMR)-defective colonic tumors. The reason for this selectivity is not known. We hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe6f5176d8661c7fe662871927d9f8
https://doi.org/10.1038/onc.2009.508

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Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase

Autor: Harry C. Au, Deena Ream-Robinson, Liz Anne Bellew, Michael Saghbini, Immo E. Scheffler, P.L.Elaine Broomfield

Publikováno v: Gene. 159:249-253

The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH and complex II) of the respiratory chain is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934–1938]. We have cloned the entire human Ip cDNA,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985e813ae05055673ff015025aa8dd8c
https://doi.org/10.1016/0378-1119(95)00162-y

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The gene for the iron sulfur protein of succinate dehydrogenase (SDH-IP) maps to human chromosome 1p35-36.1

Autor: Deena Ream-Robinson, Immo E. Scheffler, Susanne Leckschat

Publikováno v: Somatic Cell and Molecular Genetics. 19:505-511

A partial human cDNA clone for the iron-protein (IP) subunit of succinate dehydrogenase (EC 1.3.99.1) was used in Southern analyses of restriction enzyme digests of genomic human and hamster DNA as well as hamster-human hybrids containing a limited n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3642e1690efa355644a216bf5aa0d372
https://doi.org/10.1007/bf01233256

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Both microsatellite length and sequence context determine frameshift mutation rates in defective DNA mismatch repair

Autor: Dennis J. Young, Deena Ream-Robinson, Joy Holmstrom, Heekyung Chung, Claudia G. Lopez, John M. Carethers, Jenny F. Lai

It is generally accepted that longer microsatellites mutate more frequently in defective DNA mismatch repair (MMR) than shorter microsatellites. Indeed, we have previously observed that the A 10 microsatellite of transforming growth factor beta type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4893617726d8194bf8a0475d65a76e4c
https://europepmc.org/articles/PMC2912546/

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Activin Signaling in Microsatellite Stable Colon Cancers Is Disrupted by a Combination of Genetic and Epigenetic Mechanisms

Autor: Przemyslaw K. Slowik, Jennifer Cabral, Deena Ream-Robinson, Judith C. Sporn, Jeffrey Lee, Eddy Chau, Jessica Gomez, Ajay Goel, John M. Carethers, C. Richard Boland, Karen Messer, Barbara H. Jung, Aimee Anselm, Sung Kwan Shin

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 12, p e8308 (2009)

Background Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd4e34558e2bee515aa615c959614a9
http://europepmc.org/articles/PMC2789408

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Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria

Autor: Immo E. Scheffler, Harry C. Au, Deena Ream-Robinson, James T Mascarello, Amina Elbehti-Green

Publikováno v: Gene. 213(1-2)

Complex II of mitochondria contains succinate dehydrogenase and subunits to link this enzyme directly to the inner mitochondrial membrane. The four peptides of this complex are the flavoprotein (Fp) and iron–sulfur protein (Ip) of the dehydrogenase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2555782b6bf1e88a45f398ed6b41e76c
https://pubmed.ncbi.nlm.nih.gov/9714607

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