Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Deeksha Munnur"'
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 2814-2838 (2021)
The Flavivirus genus consists of >70 members including several that are considered significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be roughly categorised into two phenotypes – systemic disease involving haemo
Externí odkaz:
https://doaj.org/article/60b4bb69475a476bb561b50fa79faac3
Autor:
Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.
Externí odkaz:
https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
Autor:
Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal Malewicz
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2028-2036.e6 (2019)
Summary: Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; h
Externí odkaz:
https://doaj.org/article/fdedb83939404dee9e65c1e7a9fcb645
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Dysregulation of MacroD1 expression has been shown to be associated with the pathogenesis of several forms of cancer.
Externí odkaz:
https://doaj.org/article/e0e1309fd0fb41ab9c4c208cc98ed83e
Publikováno v:
Biochemical Society Transactions. 50:1837-1846
One of the hallmarks of antiviral responses to infection is the production of interferons and subsequently of interferon stimulated genes. Interferon stimulated gene 15 (ISG15) is among the earliest and most abundant proteins induced upon interferon
Publikováno v:
Virulence
article-version (VoR) Version of Record
Virulence, Vol 12, Iss 1, Pp 2814-2838 (2021)
article-version (VoR) Version of Record
Virulence, Vol 12, Iss 1, Pp 2814-2838 (2021)
The Flavivirus genus consists of >70 members including several that are considered significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be roughly categorised into two phenotypes – systemic disease involving haemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f84ef50369559f848e0f9d591a1ef69
https://doi.org/10.1080/21505594.2021.1996059
https://doi.org/10.1080/21505594.2021.1996059
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection
Autor:
Sumana Sanyal, Fabien Thery, Wilson W. Ng, Andreas Damianou, Antje Beling, Hidde L. Ploegh, Adan Pinto-Fernandez, Chris Ka Pun Mok, Julian Ho, Lewis Yu Lam Siu, Horace Hok Yeung Lee, Deeksha Munnur, Francis Impens, Qi Wen Teo, Denzel Eggermont, Benedikt M. Kessler, Sophie Wilhelmina van Leur
Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) (ISG15) is a ubiquitin-like modifier induced during infections and involved in host defense mechanisms. Not surprisingly, many viruses encode deISGylating activities to antagonize its effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c350ea779304531b48d7fbc6decd67b
https://doi.org/10.1038/s41590-021-01035-8
https://doi.org/10.1038/s41590-021-01035-8
Autor:
Deeksha, Munnur, Ivan, Ahel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2298
ADP-ribosylation is a widespread reversible chemical modification of macromolecular targets. Protein ADP-ribosylation has been widely studied and plays a vital role in the regulation of several biological processes. In recent years there has been inc
Autor:
Cyril Dominguez, Deeksha Munnur, Michal Malewicz, Rebekah Jukes-Jones, Ivan Ahel, George Skalka, Kelvin Cain, Mohammed Bhogadia, Joanna Somers, Ria Weston
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2028-2036.e6 (2019)
Cell Reports
Cell Reports
Summary Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood. NR4A nuclear orphan receptors were previously linked to DSB repair; ho
Autor:
Deeksha Munnur, Ivan Ahel
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613733
ADP-ribosylation is a widespread reversible chemical modification of macromolecular targets. Protein ADP-ribosylation has been widely studied and plays a vital role in the regulation of several biological processes. In recent years there has been inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc19df04a14a50f5b5e55d7acadc6605
https://doi.org/10.1007/978-1-0716-1374-0_15
https://doi.org/10.1007/978-1-0716-1374-0_15