Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Deeksha Deep"'
Autor:
Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A. Paucar Iza, Deeksha Deep, Yollanda Franco Parisotto, Logan Fisher, H. Amalia Pasolli, Valentin Thevin, Rasa Elmentaite, Maximilian Knott, Saskia Hemmers, Lorenz Jahn, Christin Friedrich, Jacob Verter, Zhong-Min Wang, Marcel van den Brink, Georg Gasteiger, Thomas G. P. Grünewald, Julien C. Marie, Christina Leslie, Alexander Y. Rudensky, Chrysothemis C. Brown
Publikováno v:
Nature. 610:752-760
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a criti
Autor:
Blossom, Akagbosu, Zakieh, Tayyebi, Gayathri, Shibu, Yoselin A, Paucar Iza, Deeksha, Deep, Yollanda Franco, Parisotto, Logan, Fisher, H Amalia, Pasolli, Valentin, Thevin, Rasa, Elmentaite, Maximilian, Knott, Saskia, Hemmers, Lorenz, Jahn, Christin, Friedrich, Jacob, Verter, Zhong-Min, Wang, Marcel, van den Brink, Georg, Gasteiger, Thomas G P, Grünewald, Julien C, Marie, Christina, Leslie, Alexander Y, Rudensky, Chrysothemis C, Brown
Publikováno v:
Nature. 610(7933)
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a criti
Autor:
Deeksha Deep, António P. Baptista, Meng Lou, John S. Tsang, Alexander Y. Rudensky, Ronald N. Germain, Kyemyung Park, Christine H. Miller, Lisa F. Boyd, Anita Gola, Grégoire Altan-Bonnet, Peter A. Savage, Harikesh S. Wong
Publikováno v:
Cell
Summary A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting host autoimmunity. We investigated homeostatic control of self-activated T cells within unperturbed tissue environments by combining high-resolut
Publikováno v:
ACS Chemical Biology. 11:25-30
Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of infections including cellulitis, pneumonia, and septicemia. The principle mechanism in antistaphylococcal host defense is opsonization with antibodies and complement
Autor:
John Bradley, J. Andrew Bradley, Eric Song, Jenna DiRito, Nancy C. Kirkiles-Smith, Michael L. Nicholson, Jordan S. Pober, W. Mark Saltzman, Alexandra S. Piotrowski-Daspit, Sathia Thiru, Sarah A. Hosgood, Kourosh Saeb-Parsy, Jiajia Cui, Deeksha Deep, Rafia S. Al-Lamki, Jan R. Kraehling, Gregory T. Tietjen
Publikováno v:
Science Translational Medicine. 9
Ex vivo normothermic machine perfusion (NMP) is a new clinical strategy to assess and resuscitate organs likely to be declined for transplantation, thereby increasing the number of viable organs available. Short periods of NMP provide a window of opp
Autor:
David Spiegel, Takuji Shoda, Samir Gautam, Maria Teresa Ferreira, Deeksha Deep, Sounok Sen, Mariana G. Pinho, Ragini Luthra, Taehan Kim
Publikováno v:
Angewandte Chemie International Edition. 54:10492-10496
Penicillin-binding proteins (PBPs) catalyze the crosslinking of peptidoglycan (PG), an essential process for bacterial growth and survival, and a common antibiotic target. Yet, despite its importance, little is known about the spatiotemporal aspects
Autor:
Surya Pandey, Cornelius C. Thaiss, Ulrich H. von Andrian, Ashwini Patil, Nicolas Chevrier, Motohiko Kadoki, Kenta Nakai, Amy J. Wagers, David Alvarez, Deeksha Deep, Magali Soumillon, Donald J. Brooks, Tarjei S. Mikkelsen
Publikováno v:
Cell. 171(2)
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic
Autor:
Linas Mazutis, Alejandra Mendoza, Rachel M. Fromme, Christina S. Leslie, Alexander Y. Rudensky, Yuri Pritykin, Vincent-Philippe Lavallée, Dana Pe'er, Charlotte E. Ariyan, Chrysothemis C. Brown, Deeksha Deep, Herman Gudjonson
Publikováno v:
Cell
Summary Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to initiate T cell responses and direct their differentiation into effector lineages. Classical DCs have been divided into two s