Coumarin-Based Aldo-Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors.

Autor: Jonnalagadda SK; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States., Duan L; Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States., Dow LF; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States., Boligala GP; School of Medicine Cancer Center, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, United States., Kosmacek E; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States., McCoy K; School of Medicine Cancer Center, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, United States., Oberley-Deegan R; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States., Chhonker YS; Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA., Murry DJ; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States.; Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68106, USA.; UNMC Center for Drug Design and Innovation, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States., Reynolds CP; School of Medicine Cancer Center, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, United States., Maurer BJ; School of Medicine Cancer Center, Texas Tech University Health Sciences Center, Lubbock, Texas, 79430, United States., Penning TM; Center of Excellence in Environmental Toxicology, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States., Trippier PC; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States.; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States.; UNMC Center for Drug Design and Innovation, University of Nebraska Medical Center, Omaha, Nebraska, 68106, United States.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Nov 04; Vol. 19 (21), pp. e202400081. Date of Electronic Publication: 2024 Sep 16.

Growth and instability of the liquid rim in the crown splash regime

Autor: Agbaglah, G., Deegan, R. D.

We study the formation, growth, and disintegration of jets following impact of a drop on a thin film of the same liquid for We < 1000 and Re < 2000 using a combination of numerical simulations and linear stability theory (Agbaglah et al. 2013). Our s

Externí odkaz: http://arxiv.org/abs/1404.7815

The Myriad Decision at 10.

Autor: Sherkow JS; College of Law and European Union Center, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA; email: jsherkow@illinois.edu.; Carle Illinois College of Medicine and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Center for Advanced Study in Biomedical Innovation Law, Faculty of Law, University of Copenhagen, Copenhagen, Denmark., Cook-Deegan R; School for the Future of Innovation in Society and Consortium for Science, Policy, and Outcomes, Arizona State University, Tempe, Arizona, USA; email: bcd@asu.edu., Greely HT; Law School, Department of Genetics, and Center for Law and the Biosciences, Stanford University, Stanford, California, USA; email: hgreely@stanford.edu.

Publikováno v: Annual review of genomics and human genetics [Annu Rev Genomics Hum Genet] 2024 Aug; Vol. 25 (1), pp. 397-419. Date of Electronic Publication: 2024 Aug 06.

Fostering reproducibility in industry-academia research

Autor: Jasny, B. R., Wigginton, N., McNutt, M., Bubela, T., Buck, S., Cook-Deegan, R., Gardner, T., Hanson, B., Hustad, C., Kiermer, V., Lazer, D., Lupia, A., Manrai, A., McConnell, L., Noonan, K., Phimister, E., Simon, B., Strandburg, K., Summers, Z., Watts, D.

Publikováno v: Science, 2017 Aug . 357(6353), 759-761.

Externí odkaz: https://www.jstor.org/stable/26399681

Prevalence of multiple long-term conditions (multimorbidity) in England: a whole population study of over 60 million people.

Autor: Valabhji J; NHS England, Wellington House, London SE1 8UG, UK.; Department of Diabetes and Endocrinology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.; Division of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2BU, UK., Barron E; NHS England, Wellington House, London SE1 8UG, UK., Pratt A; NHS Arden & Greater East Midlands Commissioning Support Unit, Westgate House, Warwick CV34 4DE, UK., Hafezparast N; Outcomes Based Healthcare Ltd, London W1G 0AN, UK., Dunbar-Rees R; Outcomes Based Healthcare Ltd, London W1G 0AN, UK., Turner EB; Outcomes Based Healthcare Ltd, London W1G 0AN, UK., Roberts K; National Institute for Health and Care Research Clinical Research Network National Coordination Centre, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK., Mathews J; National Institute for Health and Care Research Clinical Research Network National Coordination Centre, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK., Deegan R; NHS Arden & Greater East Midlands Commissioning Support Unit, Westgate House, Warwick CV34 4DE, UK., Cornelius V; NHS England, Wellington House, London SE1 8UG, UK., Pickles J; NHS England, Wellington House, London SE1 8UG, UK., Wainman G; NHS England, Wellington House, London SE1 8UG, UK., Bakhai C; NHS England, Wellington House, London SE1 8UG, UK.; Bedfordshire, Luton and Milton Keynes Integrated Care Board, LU1 2LJ, UK., Johnston DG; Department of Diabetes and Endocrinology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.; Division of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2BU, UK., Gregg EW; School of Public Health, Imperial College London, London, SW7 2BU, UK., Khunti K; Diabetes Research Centre, University of Leicester, Leicester, LE5 4PW, UK.

Publikováno v: Journal of the Royal Society of Medicine [J R Soc Med] 2024 Mar; Vol. 117 (3), pp. 104-117. Date of Electronic Publication: 2023 Oct 31.