To jump or not to jump: The Bereitschaftspotential required to jump into 192-meter abyss

Autor: Nann, M., Cohen, L. G., Deecke, L., Soekadar, S. R.

Self-initiated voluntary acts, such as pressing a button, are preceded by a negative electrical brain potential, the Bereitschaftspotential (BP), that can be recorded over the human scalp using electroencephalography (EEG). Up to now, the BP required

Externí odkaz: http://arxiv.org/abs/1801.07244

Variants in the TERT Gene Increase the Occurrence of Solar Lentigines by Modifying Telomerase Expression Exclusively in the Skin.

Autor: Deecke L; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Ohlei O; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Homann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Stagge J; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany; Department of Ophthalmology, University of Lübeck, Lübeck, Germany., Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Steinhagen-Thiessen E; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Berlin, Germany., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Demuth I; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Endocrinology and Metabolic Diseases (including Division of Lipid Metabolism), Berlin, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany., Hagelstein V; Department of Dermatology, University of Lübeck, Lübeck, Germany., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Lill CM; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany; Ageing Epidemiology Research Unit, School of Public Health, Imperial College, London, United Kingdom. Electronic address: christina.lill@uni-muenster.de.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Jun; Vol. 144 (6), pp. 1412-1415.e7. Date of Electronic Publication: 2023 Nov 27.

Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation.

Autor: Ohlei O; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany., Sommerer Y; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany., Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany., Homann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Deecke L; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Schilling M; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.; Gene Regulation of Cell Identity, Regenerative Medicine Program, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Bartrés-Faz D; Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Cattaneo G; Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Camí de les Escoles, Badalona, Barcelona, Spain., Düzel S; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany., Fjell AM; Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway., Lindenberger U; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany., Pascual-Leone Á; Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Sedghpour Sabet S; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Solé-Padullés C; Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain., Tormos JM; Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Barcelona, Spain.; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Camí de les Escoles, Badalona, Barcelona, Spain., Vetter VM; Biology of Aging Working Group, Department of Endocrinology and Metabolic Diseases, Division of Lipid Metabolism, Charité-Universitätsmedizin Berlin (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin), Berlin, Germany., Walhovd KB; Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway., Wesse T; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Wittig M; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Demuth I; Biology of Aging Working Group, Department of Endocrinology and Metabolic Diseases, Division of Lipid Metabolism, Charité-Universitätsmedizin Berlin (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin), Berlin, Germany.; Berlin Institute of Health Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany., Lill CM; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 24. Date of Electronic Publication: 2023 Dec 24.

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Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset.

Autor: Homann J; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Osburg T; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Ohlei O; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Dobricic V; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Deecke L; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany., Bos I; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, Netherlands.; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospital Leuven, Leuven, Belgium., Gabel S; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium., Scheltens P; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands., Engelborghs S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Department of Neurology and Center for Neurosciences, Universitair Ziekenhuis Brussel and Vrije Universiteit Brussel (VUB), Brussels, Belgium., Frisoni G; Department of Psychiatry, University of Geneva, Geneva, Switzerland.; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Blin O; Institut Neurosciences Timone, AIX Marseille University, Marseille, France., Richardson JC; Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, United Kingdom., Bordet R; Lille Neuroscience and Cognition, University of Lille, Inserm, CHU Lille, Lille, France., Lleó A; Memory Unit, Neurology Department, Hospital de Sant Pau, Barcelona and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Alcolea D; Memory Unit, Neurology Department, Hospital de Sant Pau, Barcelona and Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Popp J; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland.; Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland., Clark C; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zurich, Zurich, Switzerland., Peyratout G; Old Age Psychiatry, Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland., Martinez-Lage P; Department of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Donostia-San Sebastian, Spain., Tainta M; Department of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, Donostia-San Sebastian, Spain., Dobson RJB; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom.; Health Data Research UK London, University College London, London, United Kingdom.; Institute of Health Informatics, University College London, London, United Kingdom.; NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London, United Kingdom., Legido-Quigley C; Steno Diabetes Center, Copenhagen, Denmark.; King's College London, Institute of Pharmaceutical Sciences, London, United Kingdom., Sleegers K; Complex Genetics of Alzheimer's Disease Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Van Broeckhoven C; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium., Wittig M; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Lill CM; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, University College London, Queen Square Institute of Neurology, Queen Square, London, United Kingdom.; UK Dementia Research Institute at University College London, London, United Kingdom., Lovestone S; Department of Psychiatry, University of Oxford, Oxford, United Kingdom., Streffer J; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Janssen R&D, LLC. Beerse, Belgium., Ten Kate M; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, Netherlands., Vos SJB; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, Netherlands.; Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom., Visser PJ; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, Netherlands.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, Lübeck, Germany.; Department of Psychology, University of Oslo, Oslo, Norway.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Mar 21; Vol. 14, pp. 840651. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).