Zobrazeno 1 - 10 of 88 pro vyhledávání: '"Deeba N. Syed"'
1
Akademický článek
Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models
Autor: Mario Sechi, Rahul K. Lall, Saheed O Afolabi, Anant Singh, Dinesh C. Joshi, Shing-Yan Chiu, Hasan Mukhtar, Deeba N. Syed
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated tha
Externí odkaz: https://doaj.org/article/5e2df20b2938453aa0b4f7b03494c319
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2
Akademický článek
Potent anti-proliferative, pro-apoptotic activity of the Maytenus royleanus extract against prostate cancer cells: evidence in in-vitro and in-vivo models.
Autor: Maria Shabbir, Deeba N Syed, Rahul K Lall, Muhammad Rashid Khan, Hasan Mukhtar
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119859 (2015)
Prostate cancer is a leading of cause of cancer related death in men. Despite intensive investment in improving early diagnosis, it often escapes timely detection. Mortality remains high in advanced stage prostate cancer where palliative care remains
Externí odkaz: https://doaj.org/article/d9b8f82788d64896a6e8310e03b244b9
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3
Tissue microarray profiling and integrative proteomics indicate the modulatory potential of Maytenus royleanus in inhibition of overexpressed TPD52 in prostate cancers
Autor: Hasan Mukhtar, Maria Shabbir, Dara Al-Disi, Deeba N. Syed, Suhail Razak, Yasmin Badshah, Ali Almajwal, Tayyaba Afsar
Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Maytenus roylanus (MEM) is a plant with anti-proliferative effects against prostate cancer. We aimed to explore the mechanism of action of MEM in prostate cancer (PCa) by employing an in vitro global proteome approach to get useful information of var
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c276afd04c5b3a1db046fd109293385b
https://doi.org/10.1038/s41598-021-91408-8
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4
Akademický článek
Biotransformed soybean extract (BSE) inhibits melanoma cell growth and viability in vitro: involvement of nuclear factor-kappa B signaling.
Autor: Fernanda Maria Pinto Vilela, Deeba N Syed, Jean Christopher Chamcheu, Laura A Calvo-Castro, Vanessa Silveira Fortes, Maria José Vieira Fonseca, Hasan Mukhtar
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103248 (2014)
Melanoma is recognized as one of the most aggressive cancers with a relatively high propensity for metastasis. The prognosis of melanoma remains poor in spite of treatment advances, emphasizing the importance of additional preventive measures. Isofla
Externí odkaz: https://doaj.org/article/924b0bcc7572458dad1bd32aa5b42729
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5
Targeting epithelial to mesenchymal transition in prostate cancer by a novel compound, plectranthoic acid, isolated fromFicus microcarpa
Autor: Nosheen Akhtar, Deeba N. Syed, Bushra Mirza, Hasan Mukhtar, Rahul K. Lall
Publikováno v: Molecular Carcinogenesis. 57:653-663
Epithelial-to-mesenchymal transition (EMT) plays a crucial role in prostate cancer (PCa) metastasis. This has led to a surge in the efforts for identification of safer and more effective compounds which can modulate EMT and consequently inhibiting mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16924df77bd799bebf499cd91b639c6b
https://doi.org/10.1002/mc.22790
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7
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice
Autor: Imtiaz A. Siddiqui, Dodwad Sm, Chaves-Rodriquez Mi, Deeba N. Syed, Mario Sechi, Gary S. Wood, Stephane Esnault, Longley Bj, Hasan Mukhtar, Jean Christopher Chamcheu, Vaqar Mustafa Adhami, Satyshur Ka
Publikováno v: Antioxidants & Redox Signaling. 26:49-69
The treatment of psoriasis remains elusive, underscoring the need for identifying novel disease targets and mechanism-based therapeutic approaches. We recently reported that the PI3K/Akt/mTOR pathway that is frequently deregulated in many malignancie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60639b2a99a7b0c82c677fe250dc2ec0
https://doi.org/10.1089/ars.2016.6769
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8
Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1α axis regulates ER stress during high-carbohydrate feeding
Autor: Bonneville Abram, Deeba N. Syed, Sarah Lewis, James M. Ntambi, Ahmed Aljohani, Lucas O' Neill, Hasan Mukhtar, Mohammad Imran Khan
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Stearoyl CoA desaturase 1 (SCD1) is a key enzyme in lipogenesis as it catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate (18:1n9) and palmitoleate (16:1n7) from saturated fatty acids (SFA), stearate (18:0) and palmitate (16
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12aa197e5881da3b7e697fac8fd089f7
https://doi.org/10.1038/s41598-019-52339-7
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9
Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies
Autor: Ralph M. Albrecht, Hasan Mukhtar, Deeba N. Syed, AS Babatunde, Mamoru Koketsu, Olufunke E. Olorundare, Saheed O. Afolabi
Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
Plant-based therapies are being explored to prevent or treat several cancer types. The antioxidant properties of Polyalthia longifolia plant are well established. In our previous work, we demonstrated the presence of cytotoxic compounds in the methan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af70d8804032321c8b8eb9e692b18a3b
https://doaj.org/article/c4a68435a8be49049df096a46e53e280
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10
Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities
Autor: Mario Sechi, Deeba N. Syed, Nicolino Pala, Alberto Mariani, Antonio Brunetti, Hasan Mukhtar, Salvatore Marceddu, Vanna Sanna
Publikováno v: Materials Science and Engineering: C. 68:594-602
The bioactive flavonoid fisetin (FS) is a diet-derived antioxidant that is being increasingly investigated for its health-promoting effects. Unfortunately, the poor physicochemical and pharmacokinetic properties affect and limit the clinical applicat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476c750801e67f099b1b487259997394
https://doi.org/10.1016/j.msec.2016.06.042
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