Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases

Autor: Nicole D. Houston, Seth M. Steinberg, Scott L. Carter, Dee Dee K. Smart, Mark R. Gilbert, Terri S. Armstrong, Nadia Biassou, Brunilde Gril, Priscilla K. Brastianos, David Lyden, Eric M. Burton, Patricia S. Steeg, Alexandra S Zimmer, Stanley Lipkowitz

Publikováno v: Future Oncol

Brain metastases occur in up to 25–55% of patients with metastatic HER2-positive breast cancer. Standard treatment has high rates of recurrence or progression, limiting survival and quality of life in most patients. Temozolomide (TMZ) is known to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c360c8dbafa910c93a0011e9294fd4b6
https://pubmed.ncbi.nlm.nih.gov/32270710

Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint

Autor: Silvia C. Formenti, Radhe Mohan, Molykutty J. Aryankalayil, Pataje G. S. Prasanna, Stephen M. Seltzer, Søren M. Bentzen, Beverly A. Teicher, Jeffrey C. Buchsbaum, Joel E. Tepper, David Raben, Gary D. Kao, Kevin M. Prise, David G. Kirsch, Bhadrasain Vikram, Fei-Fei Liu, Deborah Citrin, Daphne A. Haas-Kogan, Mansoor M. Ahmed, James B. Mitchell, Dee Dee K. Smart, Jacek Capala, Dudley T. Goodhead, Marc S. Mendonca, Ceferino Obcemea, Quynh-Thu Le, C. Norman Coleman, Iris Eke

Publikováno v: Ahmed, M M, Coleman, C N, Mendonca, M, Bentzen, S, Vikram, B, Seltzer, S M, Goodhead, D, Obcemea, C, Mohan, R, Prise, K M, Capala, J, Citrin, D, Kao, G, Aryankalayil, M, Eke, I, Buchsbaum, J C, G S Prasanna, P, Liu, F-F, Le, Q-T, Teicher, B, Kirsch, D G, Smart, D, Tepper, J, Formenti, S, Haas-Kogan, D, Raben, D & Mitchell, J 2018, ' Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint ', Cancer Research, vol. 78, no. 9 . https://doi.org/10.1158/0008-5472.CAN-17-3760

The ability to physically target radiotherapy using image-guidance is continually improving with photons and particle therapy that include protons and heavier ions such as carbon. The unit of dose deposited is the gray (Gy); however, particle therapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51c83efd8d47f405a8cbceff15654d1
https://pure.qub.ac.uk/en/publications/workshop-report-for-cancer-research-defining-the-shades-of-gy-utilizing-the-biological-consequences-of-radiotherapy-in-the-development-of-new-treatment-approachesmeeting-viewpoint(c65d8d74-c767-4607-8247-e07f07bc916b).html

The epigenome as a molecular marker and target

Autor: Dee Dee K. Smart, Lunching Sun, Kheem S. Bisht, Phuongmai Nguyen, Allen S. Ho, Rania T. Awwad, David Gius, C. Matthew Bradbury, Lei Huang

Publikováno v: Cancer. 104:1789-1793

Tumor cell proliferation, de-differentiation, and progression depend on a complex combination of altered cell cycle regulation, excessive growth factor pathway activation, and decreased apoptosis. The understanding of these complex mechanisms should

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f7a2c7b0efb1e49bcfb95310cc89135
https://doi.org/10.1002/cncr.21395

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach

Autor: Lynn Young, Eric Y. Chuang, Sheri A. Brandenburg, Lunching Sun, Peter J. Munson, Allen S. Ho, C. Matthew Bradbury, Hengmi Cui, Shuping Zhao, Yali Hu, Kheem S. Bisht, David Gius, John A. Cook, Dee Dee K. Smart, James B. Mitchell, David M. Mattson, Andrew P. Feinberg

Publikováno v: Cancer cell. 6(4)

We tested the hypothesis that the effects on gene expression of altered DNA methylation by 5-aza-2′-deoxycytidine (5-aza-CdR) and genetic (DNMT knockout) manipulation of DNA are similar, and distinct from Trichostatin A (TSA)-induced chromatin deco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58235c7639f95467d1b540b06116d03
https://pubmed.ncbi.nlm.nih.gov/15488759