Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dedeke Rockx-Brouwer"'
Autor:
Pauline Schneider, Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Dedeke Rockx-Brouwer, Fabienne R. S. Adriaanse, Veerle Hoeve, Irene Paassen, Jarno Drost, Rob Pieters, Ronald W. Stam
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13207 (2023)
In acute lymphoblastic leukemia (ALL), chromosomal translocations involving the KMT2A gene represent highly unfavorable prognostic factors and most commonly occur in patients less than 1 year of age. Rearrangements of the KMT2A gene drive epigenetic
Externí odkaz:
https://doaj.org/article/48321f7aa0cb4008bd0e8579ccc7ca3c
Autor:
Wouter Johannes Petrus van den Braak, Bella Monica, Diana Limpens, Dedeke Rockx-Brouwer, Matthijn de Boer, Dinja Oosterhoff
Publikováno v:
Viruses, Vol 14, Iss 10, p 2235 (2022)
Human rhinoviruses (HRVs) are small non-enveloped RNA viruses that belong to the Enterovirus genus within the Picornaviridae family and are known for causing the common cold. Though symptoms are generally mild in healthy individuals, the economic bur
Externí odkaz:
https://doaj.org/article/e2379990610a4fbaa628cf09947247db
Autor:
K Lane Warmbrod, Edward I Patterson, Tiffany F Kautz, Adam Stanton, Dedeke Rockx-Brouwer, Birte K Kalveram, Kamil Khanipov, Saravanan Thangamani, Yuriy Fofanov, Naomi L Forrester
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007610 (2019)
The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regener
Externí odkaz:
https://doaj.org/article/5a9fb94501eb427fb71ee1f2e14af2b6
Autor:
Lynn Soong, Nicole L Mendell, Juan P Olano, Dedeke Rockx-Brouwer, Guang Xu, Yenny Goez-Rivillas, Claire Drom, Thomas R Shelite, Gustavo Valbuena, David H Walker, Donald H Bouyer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004884 (2016)
Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studi
Externí odkaz:
https://doaj.org/article/358516a7395e48ddb56afa335825374a
Autor:
Claire Smalley, Jeremy Bechelli, Dedeke Rockx-Brouwer, Tais Saito, Sasha R Azar, Nahed Ismail, David H Walker, Rong Fang
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157231 (2016)
Rickettsiae actively escape from vacuoles and replicate free in the cytoplasm of host cells, where inflammasomes survey the invading pathogens. In the present study, we investigated the interactions of Rickettsia australis with the inflammasome in bo
Externí odkaz:
https://doaj.org/article/6e4d1c7a5d1e46da88fd95b2403ccb3f
Autor:
Audrey Chong, Robert Child, Tara D Wehrly, Dedeke Rockx-Brouwer, Aiping Qin, Barbara J Mann, Jean Celli
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67965 (2013)
Francisella tularensis is a highly infectious bacterium whose virulence relies on its ability to rapidly reach the macrophage cytosol and extensively replicate in this compartment. We previously identified a novel Francisella virulence factor, DipA (
Externí odkaz:
https://doaj.org/article/5cab4600db4a4ef19ec4c01080f2108b
Autor:
Dedeke Rockx-Brouwer, Audrey Chong, Tara D Wehrly, Robert Child, Deborah D Crane, Jean Celli, Catharine M Bosio
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37752 (2012)
Tularemia, caused by the gram-negative bacterium Francisella tularensis, is a severe, sometimes fatal disease. Interest in tularemia has increased over the last decade due to its history as a biological weapon. In particular, development of novel vac
Externí odkaz:
https://doaj.org/article/354bf3ef51e0422b8362ef4ce631232c
Autor:
Ingrid Spaan, Niels van Nieuwenhuijzen, Thomas Kimman, Dedeke Rockx-Brouwer, Ralph G. Tieland, Madelon M. Maurice, Monique C. Minnema, Reinier A. Raymakers, Victor Peperzak
Publikováno v:
Blood Advances. 7:1103-1107
Autor:
Pauline Schneider, Susan T.C.J.M. Arentsen-Peters, Nicholas T. Crump, Alastair Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Kirsten S. Vrenken, Dedeke rockx-Brouwer, Ziqin Tang, Wilbert P. Vermeij, Anja De Jong, Bianca Koopmans, M.Emmy M. Dolman, Thomas A. Milne, Rob Pieters, Ronald W. Stam
Publikováno v:
Blood. 140:8760-8761
Autor:
Luke Jones, Ronald W. Stam, Pauline Schneider, Tito Candelli, Dedeke Rockx-Brouwer, Eduard Bodewes, Frank C. P. Holstege, P. Castro, Thanasis Margaritis, Rob Pieters
Publikováno v:
Leukemia
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30–40%. The majority of patients initially show therapy response, but in two-