A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model.

Autor: Gilbertie JM; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States., Schaer TP; Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States., Engiles JB; Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States.; Department of Pathobiology New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States., Seiler GS; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Deddens BL; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Schubert AG; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Jacob ME; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States.; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Stefanovski D; Department of Clinical Studies New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States., Ruthel G; Department of Pathobiology New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA, United States., Hickok NJ; Department of Orthopedic Surgery, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, United States., Stowe DM; Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Frink A; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States., Schnabel LV; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 May 30; Vol. 12, pp. 895022. Date of Electronic Publication: 2022 May 30 (Print Publication: 2022).