Zobrazeno 1 - 10
of 827
pro vyhledávání: '"Decuzzi, P."'
Publikováno v:
Journal of Fluid and Structures 82 (2018) 638-650
In vascular targeted therapies, blood-borne carriers should realize sustained drug release from the luminal side towards the diseased tissue. In this context, such carriers are required to firmly adhere to the vessel walls for a sufficient period of
Externí odkaz:
http://arxiv.org/abs/2210.06043
Autor:
Agnese Fragassi, Antonietta Greco, Martina Di Francesco, Luca Ceseracciu, Aiman Abu Ammar, Israel Dvir, Thomas Lee Moore, Haytam Kasem, Paolo Decuzzi
Publikováno v:
Friction, Vol 12, Iss 3, Pp 539-553 (2023)
Abstract Nano- and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications, from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic joints. Here, we
Externí odkaz:
https://doaj.org/article/cd5ecfc2117c4100bf13fa92cafd21c9
Akademický článek
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Akademický článek
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Autor:
Breanne Sparta, Nont Kosaisawe, Michael Pargett, Madhura Patankar, Nicholaus DeCuzzi, John G Albeck
Publikováno v:
eLife, Vol 12 (2023)
mTORC1 senses nutrients and growth factors and phosphorylates downstream targets, including the transcription factor TFEB, to coordinate metabolic supply and demand. These functions position mTORC1 as a central controller of cellular homeostasis, but
Externí odkaz:
https://doaj.org/article/d3af77c253d949698c76c6b59e7a8f80
Metastases are the primary cause of death in cancer patients. Small animal models are helping in dissecting some of key features in the metastatic cascade. Yet, tools for systematically analyze the contribution of blood flow, vascular permeability, i
Externí odkaz:
http://arxiv.org/abs/1907.12742
Distant spreading of primary lesions is modulated by the vascular dynamics of circulating tumor cells (CTCs) and their ability to establish metastatic niches. While the mechanisms regulating CTC homing in specific tissues are yet to be elucidated, it
Externí odkaz:
http://arxiv.org/abs/1907.09284
Autor:
Di Francesco, Martina, Primavera, Rosita, Romanelli, Davide, Palomba, Roberto, Catelani, Tiziano, Celia, Christian, Di Marzio, Luisa, Fresta, Massimo, Di Mascolo, Daniele, Decuzzi, Paolo
A variety of microparticles have been proposed for the sustained and localized delivery of drugs whit the objective of increasing therapeutic indexes by circumventing filtering organs and biological barriers. Yet, the geometrical, mechanical and ther
Externí odkaz:
http://arxiv.org/abs/1903.03363
Publikováno v:
Computers and Fluids, 2019, 180, pp. 41-53
Modeling the transport of deformable capsules under different flow regimens is crucial in a variety of fields, including oil rheology, blood flow and the dispersion of pollutants. The aim of this study is twofold. Firstly, a combined Lattice Boltzman
Externí odkaz:
http://arxiv.org/abs/1903.03356
Autor:
Colasuonno, Marianna, Palange, Anna Lisa, Aid, Rachida, Ferreira, Miguel, Mollica, Hilaria, Palomba, Roberto, Emdin, Michele, Del Sette, Massimo, Chauvierre, Cédric, Letourneur, Didier, Decuzzi, Paolo
Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and s
Externí odkaz:
http://arxiv.org/abs/1903.07585