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Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials

Autor: De Grijse, J, Asanghanwa, M, Nouthe, B, Albrecher, N, Goubert, P, Vermeulen, I, Vander Meeren, Sam, Decochez, K, Weets, I, Keymeulen, B, Lampasona, V, Wenzlau, J, Hutton, J C, Pipeleers, D, Gorus, F K, Belgian Diabetes Registry

Publikováno v: Diabetologia. 53:517-524

AIMS/HYPOTHESIS: We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02a1d3f962fbb842155190cd72e6ece
https://doi.org/10.1007/s00125-009-1618-y

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IA-2 autoantibodies predict impending Type I diabetes in siblings of patients

Autor: Decochez, K, De Leeuw, I H, Keymeulen, B, Mathieu, C, Rottiers, R, Weets, I, Vandemeulebroucke, E, Truyen, I, Kaufman, L, Schuit, F C, Pipeleers, D G, Gorus, F K, Belgian Diabetes Registry, Beckers, Dominique

Publikováno v: Diabetologia, Vol. 45, no.12, p. 1658-66 (2002)
Diabetologia

Aims/hypothesis. Multiple islet autoantibody positivity is currently believed to best predict progression to Type I (insulin-dependent) diabetes mellitus. We compared its predictive value with that of positivity for a particular type of islet autoant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9d692d5d348f17c66a32cbce6e5285
https://doi.org/10.1007/s00125-002-0949-8

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Screening naar pregestationele diabetes mellitus bij zwangerschap(swens) en naar zwangerschapsdiabetes : de consensus van de VDV, de VVOG en Domus Medica van 2012

Autor: Benhalima, K., Mathieu, C., Decochez, K., de Block, Christophe, Wens, Johan

Publikováno v: Tijdschrift voor geneeskunde

Naast de wereldwijde toename van diabetes mellitus type 2 (DM2) in jongere leeftijdscategorieën neemt in de westerse wereld ook de leeftijd toe waarop vrouwen zwanger worden. Het vroegtijdig opsporen van dysglykemie vóór of zeer vroegtijdig in de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2097::24667bc0b7f6f67b3e6905a853f9a8ed
https://hdl.handle.net/10067/1065090151162165141

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An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age

Autor: Vermeulen, Isabel, Weets, I, Costa, O, Asanghanwa, M, Verhaeghen, K, Decochez, K, Ruige, J, Casteels, Kristina, Wenzlau, J, Hutton, JC, Pipeleers, DG, Gorus, FK, Belgian Diabetes Registry

The appearance of autoantibodies (Abs) before diabetes onset has mainly been studied in young children. However, most patients develop type 1 diabetes after the age of 15 years. In first-degree relatives aged under 40 years, we investigated the frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84db9296e758a562c459cd8494f92f8a
https://lirias.kuleuven.be/handle/123456789/665553

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Screening naar pregestationele diabetes mellitus bij zwangerschap(swens) en naar zwangerschapsdiabetes : de consensus van de VDV, de VVOG en Domus Medica van 2012

Autor: Banhalima, K., Mathieu, C., Decochez, K., de Block, Christophe, Van Gaal, Luc, Jacquemyn, Yves

Publikováno v: Gunaïkeia: Nederlandse uitgave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2097::4d860cde592ca3bf3b5299d618baec5d
https://hdl.handle.net/10067/1228860151162165141

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Insulin treatment in IA-2A-positive relatives of type 1 diabetic patients

Autor: Vandemeulebroucke, E, Gorus, F K, Decochez, K, Weets, I, Keymeulen, B, De Block, C, Tits, J, Pipeleers, D G, Mathieu, C, Belgian Diabetes Registry, Beckers, Dominique

Publikováno v: Diabetes & metabolism, Vol. 35, no.4, p. 319-27 (2009)
Diabetes & metabolism

Aims We examined whether parenteral regular insulin can prevent diabetes in IA-2 antibody-positive (IA-2A+) relatives of type 1 diabetic patients, using a trial protocol that differed substantially from that of the Diabetes Prevention Trial-1. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bae9581af81eda1b7218bf996d50ad
https://pubmed.ncbi.nlm.nih.gov/19647467

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