Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Declan P McKernan"'
Autor:
Gerard eClarke, Declan P McKernan, Gabor eGaszner, Eamonn M Quigley, John F Cryan, Timothy G Dinan
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised
Externí odkaz:
https://doaj.org/article/6fa7ef3598f046f1aa8f1857be5455e2
Autor:
Declan P McKernan, Aoife Nolan, Elizabeth K Brint, Siobhain M O'Mahony, Niall P Hyland, John F Cryan, Timothy G Dinan
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8226 (2009)
BackgroundIrritable bowel syndrome (IBS) is largely viewed as a stress-related disorder caused by aberrant brain-gut-immune communication and altered gastrointestinal (GI) homeostasis. Accumulating evidence demonstrates that stress modulates innate i
Externí odkaz:
https://doaj.org/article/0ee5709c37c64f76ac4beb5946299e1b
Autor:
Sinead King, David Mothersill, Laurena Holleran, Saahithh Redddi Patlola, Tom Burke, Ross McManus, Marcus Kenyon, Colm McDonald, Brian Hallahan, Aiden Corvin, Derek W. Morris, John P. Kelly, Declan P. McKernan, Gary Donohoe
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Childhood trauma (CT) is associated with lower cognitive and social cognitive function in schizophrenia. Recent evidence suggests that the relationship between CT and cognition is mediated by both low-grade systemic inflammation and reduced
Externí odkaz:
https://doaj.org/article/17c375194589468c9b8d64ca5de505dc
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1188 (2023)
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that are ubiquitously expressed in the human body. They protect the brain and central nervous system from self and foreign antigens/pathogens. The immune response elicite
Externí odkaz:
https://doaj.org/article/04cf542d6880461db0ffacf3014bc680
Publikováno v:
Journal of Psychiatric Research. 160:126-136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a18fc8d3eaaab7d613efcf15bd5e03aa
https://doi.org/10.1016/j.jpsychires.2023.01.042
https://doi.org/10.1016/j.jpsychires.2023.01.042
Autor:
Claire L. Feerick, Declan P. McKernan
Publikováno v:
Immunopharmacology and Immunotoxicology. 44:99-109
Background: The intracellular NOD-like receptor (NLR) family of pathogen recognition receptors (PRRa) is involved in initiating the innate immune response of which NOD1 and NOD2 are the best-characterized members. Aberrant expression of NOD1 and NOD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebaef0d239752d90f70e8f96b19fc0b
https://doi.org/10.1080/08923973.2021.2007264
https://doi.org/10.1080/08923973.2021.2007264
Autor:
Tom Burke, Christina Gleeson, Laurena Holleran, David Mothersill, Jessica Holland, Laura Costello, Ruán Kane, Declan P. McKernan, Derek W. Morris, John P. Kelly, Aiden P. Corvin, Brian P. Hallahan, Colm McDonald, Gary Donohoe
Publikováno v:
Brain Sciences; Volume 12; Issue 9; Pages: 1208
Objective: Schizophrenia is a complex functionally debilitating neurodevelopmental disorder, with associated social cognitive impairment. Corpus Callosum (CC) white matter tracts deficits are reported for people with schizophrenia; however, few studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fce17dee4b5b72d402720b43915293
https://pubmed.ncbi.nlm.nih.gov/36138944
https://pubmed.ncbi.nlm.nih.gov/36138944
Publikováno v:
Progress in neuro-psychopharmacologybiological psychiatry. 121
Schizophrenia is a complex psychiatric disorder that includes positive and negative symptoms but also debilitating cognitive deficits. Current pharmacological interventions do not target these deficits. Recent evidence suggests a connection between s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb0af377b9c076f1d7a8573f64ce79c
https://pubmed.ncbi.nlm.nih.gov/36283512
https://pubmed.ncbi.nlm.nih.gov/36283512
Autor:
Laura Costello, Maria R. Dauvermann, Giulia Tronchin, Laurena Holleran, David Mothersill, Karolina I. Rokita, Ruán Kane, Brian Hallahan, Aiden Corvin, Derek Morris, Declan P. McKernan, John Kelly, Colm McDonald, Gary Donohoe, Dara M. Cannon
Publikováno v:
Psychiatry Research: Neuroimaging. 332:111639
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c233e8c14fbe782642ea5682a1b3b79
https://doi.org/10.1016/j.pscychresns.2023.111639
https://doi.org/10.1016/j.pscychresns.2023.111639
Publikováno v:
Psychiatry investigation. 19(12)
Objective Immune system dysregulation is hypothesised to be central to the aetiopathogenesis of schizophrenia; however, the role of sterile inflammation remains unclear. Damage associated molecular patterns are key initiators of sterile inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d2c51307d386df74c73adf95f3057b
https://pubmed.ncbi.nlm.nih.gov/36588432
https://pubmed.ncbi.nlm.nih.gov/36588432