Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Declan J. James"'
Autor:
Declan J James, Thomas F J Martin
Publikováno v:
Frontiers in Endocrinology, Vol 4 (2013)
Abstract. CAPS (Calcium-dependent Activator Protein for Secretion, aka CADPS) and Munc13 (Mammalian Unc-13) proteins function to prime vesicles for Ca2+-triggered exocytosis in neurons and neuroendocrine cells. CAPS and Munc13 proteins contain conser
Externí odkaz:
https://doaj.org/article/3e1122d728d44dbbb60c1059e33a5a8a
Autor:
Ellen Crummy, Rehan Qurashi, Sang Su Woo, Elle Kielar-Grevstad, Declan J. James, Thomas Martin, Joseph Esquibel, Melanie Quintana Serrano, Judy A. Kowalchyk, Stephen Bruinsma
Publikováno v:
The Journal of Biological Chemistry
Ca2+-dependent secretory granule fusion with the plasma membrane is the final step for the exocytic release of inflammatory mediators, neuropeptides, and peptide hormones. Secretory cells use a similar protein machinery at late steps in the regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602fdda45c22355c44ab7d25d7921714
http://europepmc.org/articles/PMC5971468
http://europepmc.org/articles/PMC5971468
Publikováno v:
Molecular Biology of the Cell
Munc13-4, a Ca2+-dependent SNARE/phospholipid-binding protein on secretory granules (SGs), functions as a Ca2+ sensor for SG exocytosis and SG-SG fusion. SG-SG fusion plus fusion with recycling endosomes generates large (>2.4 μm) Munc13-4+/Rab7+/Rab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ac472e383274ef07fcd8d509fae104
https://doi.org/10.1091/mbc.e16-08-0617
https://doi.org/10.1091/mbc.e16-08-0617
Publikováno v:
Advances in Enzyme Regulation. 50:62-70
Ca2+-triggered vesicle exocytosis in neuro endocrine cells requires priming reactions that follow vesicle tethering/docking and precede triggered fusion. Priming requires PI(4,5)P2 and priming factors, and likely involves SNARE protein complex assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44f7aae32862648720408366fb38b4d
https://doi.org/10.1016/j.advenzreg.2009.10.012
https://doi.org/10.1016/j.advenzreg.2009.10.012
Publikováno v:
Proceedings of the National Academy of Sciences. 106:17308-17313
Ca 2+ -dependent activator protein for secretion (CAPS) is an essential factor for regulated vesicle exocytosis that functions in priming reactions before Ca 2+ -triggered fusion of vesicles with the plasma membrane. However, the precise events that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d43e2d8a488f5418efaf87e9a12277c
https://doi.org/10.1073/pnas.0900755106
https://doi.org/10.1073/pnas.0900755106
Publikováno v:
The Journal of Cell Biology
Phosphatidylinositol 4,5-bisphosphate (PI 4,5-P(2)) on the plasma membrane is essential for vesicle exocytosis but its role in membrane fusion has not been determined. Here, we quantify the concentration of PI 4,5-P(2) as approximately 6 mol% in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ee5281d0c59bee649824eb456031ef
https://doi.org/10.1083/jcb.200801056
https://doi.org/10.1083/jcb.200801056
Autor:
Greg Kabachinski, D. Michelle Kielar-Grevstad, Xingmin Aaron Zhang, Thomas Martin, Declan J. James
Publikováno v:
Molecular Biology of the Cell
American Society for Cell Biology
American Society for Cell Biology
The exocytosis of dense-core vesicles requires a priming step during which SNARE protein complexes assemble. CAPS, which assembles SNARE complexes and is required for vesicle priming, was imaged during events of single-vesicle fusion by TIRF microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a397176e243101312bfb5201837ee196
https://pubmed.ncbi.nlm.nih.gov/26700319
https://pubmed.ncbi.nlm.nih.gov/26700319
Autor:
Jmc Connell, Declan J. James, Gwyn W. Gould, Anna F. Dominiczak, D. I. Graham, Ian P. Salt, M. Collison, Geoffrey D. Holman
Publikováno v:
Diabetologia. 48:539-546
Insulin-stimulated glucose transport is impaired in a genetic model of hypertension, the stroke-prone spontaneously hypertensive rat (SHRSP), yet the molecular mechanisms that underlie this defect in the animals remain unclear.We examined the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9976265a6aa39b6859e145f1c2158695
https://doi.org/10.1007/s00125-005-1674-x
https://doi.org/10.1007/s00125-005-1674-x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1693(2):81-89
SNARE proteins play a central role in the process of intracellular membrane fusion. Indeed, the interaction of SNAREs present on two opposing membranes is generally believed to provide the driving force to initiate membrane fusion. Eukaryotic cells e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d5608e50be85ee2852b695cf49707f
Autor:
Thomas Martin, Hiroshi Takeuchi, Zhao Zhang, Masato Hirata, Jing Gao, Declan J. James, Da Guang Wang
Publikováno v:
The Journal of biological chemistry. 288(11)
Membrane fusion for exocytosis is mediated by SNAREs, forming trans-ternary complexes to bridge vesicle and target membranes. There is an array of accessory proteins that directly interact with and regulate SNARE proteins. PRIP (phospholipase C-relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d21be836f7990a411b123dfa84611a
https://pubmed.ncbi.nlm.nih.gov/23341457
https://pubmed.ncbi.nlm.nih.gov/23341457