Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Declan Flynn"'
Autor:
Jean G. Sathish, Siddhartha Bhatt, Jamie K. DaSilva, Declan Flynn, Stephen Jenkinson, Amit S. Kalgutkar, Maggie Liu, Balasubramanian Manickam, Jason Pinkstaff, William J. Reagan, Norimitsu Shirai, Ahmed M. Shoieb, Madhu Sirivelu, Saurabh Vispute, Allison Vitsky, Karen Walters, Todd A. Wisialowski, Lawrence W. Updyke
Publikováno v:
International journal of toxicology. 41(4)
COVID-19 is a potentially fatal infection caused by the SARS-CoV-2 virus. The SARS-CoV-2 3CL protease (Mpro) is a viral enzyme essential for replication and is the target for nirmatrelvir. Paxlovid (nirmatrelvir co-administered with the pharmacokinet
Publikováno v:
World Journal of Diabetes
BACKGROUND Telemedicine is defined as the delivery of health services via remote communication and technology. It is a convenient and cost-effective method of intervention, which has shown to be successful in improving glyceamic control for type 2 di
Autor:
Dilinie P. Fernando, Gary Erik Aspnes, Sophie Y. Lavergne, Daniel W. Kung, Michael Herr, I. D. Pardo, Qifang Li, Norimitsu Shirai, Bryan Goodwin, Suvi T. M. Orr, Jun Zhou, Julie Purkal, Matthew S. Dowling, Kentaro Futatsugi, R. J. Barnes, Declan Flynn, Ahmed M. Shoieb, David Hepworth, T. J. Schmahai, Mark Niosi, W. P. Gorczyca, Kim Huard, John C. Pettersen, Sylvie Perez, Shawn Cabral, James R. Gosset, Theunis C. Goosen
Publikováno v:
MedChemComm. 8:771-779
Small molecule DGAT2 inhibitors have shown promise for the treatment of metabolic diseases in preclinical models. Herein, we report the first toxicological evaluation of imidazopyridine-based DGAT2 inhibitors and show that the arteriopathy associated
Publikováno v:
Circulation Research. 125
The absence of effective therapeutic treatments that can restore function in patients with heart failure necessitates the identification of new mechanisms and strategies to improve outcomes. Strategies that directly target the cardiomyocyte and have
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Autor:
Jo Ann Davis, Christopher F. Bigge, Mehran Jalaie, Seungil Han, Jeffrey F. Ohren, Jing Chen, Noel A. Powell, Fred A. Ciske, Agustin Casimiro-Garcia, Teresa Ellis, Ronald J. Heemstra, Declan Flynn, Nadia Esmaeil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:767-772
Identification of a series of imidazo[4,5-c]pyridin-4-one derivatives that act as dual angiotensin II type 1 (AT1) receptor antagonists and peroxisome proliferator-activated receptor-γ (PPARγ) partial agonists is described. Starting from a known AT
Autor:
Martin B. Brenner, Joseph S. Warmus, Jeffrey S. Dubins, Liuqing Wei, Janice E. Chin, Nicole S. Roush, David Hepworth, Angela Wolford, Mei Li, Sophie Y. Lavergne, Sandra M. Jennings, Wenhua Jiao, Kevin B. Bahnck, Denise Gautreau, David W. Piotrowski, Joanne Buxton, John R. Hadcock, Matthew F. Sammons, Declan Flynn, Michael Herr, Benjamin D. Stevens, Steven B. Coffey, Kentaro Futatsugi, Michael John Munchhof, Jian Wang, Terri Hinchey, Suvi T. M. Orr, Gregory Storer, Angel Guzman-Perez, Bryan Li, Ann M. Janssen
Publikováno v:
MedChemComm. 4:205-210
Reported herein is a medicinal chemistry effort towards the identification of orally available TGR5 agonist 12, which served as a dog tool compound for studies to increase confidence in this mechanism. With the challenge of striking the balance of TG
Autor:
Joseph S. Warmus, Steven B. Coffey, John R. Hadcock, Liuqing Wei, Kevin Daniel Freeman-Cook, Martin B. Brenner, Kentaro Futatsugi, Suvi T. M. Orr, Nicole S. Roush, Angela Wolford, David W. Piotrowski, David Hepworth, Joanne Buxton, Sophie Y. Lavergne, Michael Herr, Gregory Storer, Janice E. Chin, Jian Wang, Ann M. Janssen, Terri Hinchey, Raman Sharma, Allyn T. Londregan, Amit S. Kalgutkar, Sandra M. Jennings, Wenhua Jiao, Declan Flynn
Publikováno v:
ACS Medicinal Chemistry Letters. 4:63-68
Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 ag
Autor:
Declan Flynn, Michelle Hemkens, Todd Wisialowski, Siddhartha Bhatt, Jill Steidl-Nichols, Dingzhou Li
Publikováno v:
Journal of pharmacological and toxicological methods. 81
Cardiovascular (CV) toxicity and related attrition are a major challenge for novel therapeutic entities and identifying CV liability early is critical for effective derisking. CV safety pharmacology studies in rats are a valuable tool for early inves
Autor:
Chad L. Stoner, Teresa Ellis, Robert Ostroski, Ronald J. Heemstra, Jeffrey F. Ohren, Nadia Esmaeil, Christopher F. Bigge, Geyer Andrew George, Jo Ann Davis, Mehran Jalaie, Declan Flynn, Filzen Gary Frederick, Agustin Casimiro-Garcia, Danette Dudley, Jeremy J. Edmunds, Robert P. Schaum, Jing Chen
Publikováno v:
Journal of Medicinal Chemistry. 54:4219-4233
Mining of an in-house collection of angiotensin II type 1 receptor antagonists to identify compounds with activity at the peroxisome proliferator-activated receptor-γ (PPARγ) revealed a new series of imidazo[4,5-b]pyridines 2 possessing activity at