Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Declan F McCole"'
Autor:
Stephanie J King, Declan F McCole
Publikováno v:
Intestinal Research, Vol 17, Iss 2, Pp 177-191 (2019)
Inflammatory bowel diseases (IBD) are chronic conditions of the gastrointestinal tract-the main site of host-microbial interaction in the body. Development of IBD is not due to a single event but rather is a multifactorial process where a patient’s
Externí odkaz:
https://doaj.org/article/1f66979f21b64e1195e9d4aa011a3327
Autor:
Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73703 (2013)
Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells i
Externí odkaz:
https://doaj.org/article/c67f23b068f14b51b0ab161c1eca2c47
Autor:
Poonamjot Deol, Paul Ruegger, Geoffrey D. Logan, Ali Shawki, Jiang Li, Jonathan D. Mitchell, Jacqueline Yu, Varadh Piamthai, Sarah H. Radi, Sana Hasnain, Kamil Borkowski, John W. Newman, Declan F. McCole, Meera G. Nair, Ansel Hsiao, James Borneman, Frances M. Sladek
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTInflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18
Externí odkaz:
https://doaj.org/article/5cd2f4244d6b4c3b8efb161aa4fbaa8c
Autor:
Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 1, Pp 39-62 (2023)
Background & Aims: Loss-of-function variants in the PTPN2 gene are associated with increased risk of inflammatory bowel disease. We recently showed that Ptpn2 is critical for intestinal epithelial cell (IEC) barrier maintenance, IEC–macrophage comm
Externí odkaz:
https://doaj.org/article/6312182efc1f47dca7056b2a59fb791d
Autor:
Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Macrophages intimately interact with intestinal epithelial cells, but the consequences of defective macrophage–epithelial cell interactions for protection against enteric pathogens are poorly understood. Here, we show that in mice with a deletion i
Externí odkaz:
https://doaj.org/article/4a7e0dcb82a94f50a7e8005e4bb6f94c
Autor:
Ali Shawki, Rocio Ramirez, Marianne R. Spalinger, Paul M. Ruegger, Anica Sayoc-Becerra, Alina N. Santos, Pritha Chatterjee, Vinicius Canale, Jonathan D. Mitchell, John C. Macbeth, Casey M. Gries, Michel L. Tremblay, Ansel Hsiao, James Borneman, Declan F. McCole
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1547-1566 (2020)
Inflammatory bowel disease (IBD) pathogenesis involves significant contributions from genetic and environmental factors. Loss-of-function single-nucleotide polymorphisms (SNPs) in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene incr
Externí odkaz:
https://doaj.org/article/20562da928e4413393bb29a2492d7c9e
Autor:
Young Su Park, Sang Bum Kang, Ronald R. Marchelletta, Harrison M. Penrose, Roos Ruiter-Visser, Barbara Jung, Michael J. Docherty, Brigid S. Boland, William J. Sandborn, Declan F. McCole
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 811 (2023)
The prostone analog, lubiprostone, is approved to manage constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal barrier function in animal models of colitis. The aim of this study was to determine if lubipros
Externí odkaz:
https://doaj.org/article/5f068f2b880b4b1ab6c054eb34c860c1
Autor:
Marianne R. Spalinger, Roberto Manzini, Larissa Hering, Julianne B. Riggs, Claudia Gottier, Silvia Lang, Kirstin Atrott, Antonia Fettelschoss, Florian Olomski, Thomas M. Kündig, Michael Fried, Declan F. McCole, Gerhard Rogler, Michael Scharl
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1835-1848 (2018)
Summary: Variants in the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with inflammatory disorders, including inflammatory bowel diseases, rheumatoid arthritis, and type 1 diabetes. The anti-inflammatory
Externí odkaz:
https://doaj.org/article/ca112df31c744a088f3ad91228a70e72
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 840 (2021)
The epithelial barrier forms the interface between luminal microbes and the host immune system and is the first site of exposure to many of the environmental factors that trigger disease activity in chronic inflammatory bowel disease (IBD). Disruptio
Externí odkaz:
https://doaj.org/article/ce7d44721d1340108897f773b6e4366a
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coliSummary
Autor:
Ali Shawki, Declan F. McCole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 1, Pp 41-50 (2017)
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens. Inflammation pl
Externí odkaz:
https://doaj.org/article/d057e4e8cd454d36a50368b51a83af3e