Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Declan Doherty"'
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Akademický článek
Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling.
Autor: Wai-Ping Lee, Sarita Jena, Declan Doherty, Jaganathan Ventakesh, Joachim Schimdt, Julie Furmick, Tim Widener, Jana Lemau, Peter W Jurutka, Paul D Thompson
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89506 (2014)
Vitamin D receptor (VDR) is a substrate for modification with small ubiquitin-like modifier (SUMO). To further assess the role of reversible SUMOylation within the vitamin D hormonal response, we evaluated the effects of sentrin/SUMO-specific proteas
Externí odkaz: https://doaj.org/article/a55f98776a75465e91054050de0ad76c
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2
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice
Autor: Rebecca J. Ingram, Leslie Holsinger, Donna M. Small, Richard Williams, Robert Booth, Marcus A. Mall, Declan Doherty, Clifford C. Taggart, Ryan Brown, Sinéad Weldon, J. Stuart Elborn
Publikováno v: Mediators of Inflammation, Vol 2021 (2021)
Brown, R, Small, D, Doherty, D F, Holsinger, L, Booth, R, Williams, R, Ingram, R J, Elborn, J S, Mall, M A, Taggart, C C & Weldon, S 2021, ' Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice ', Mediators of Inflammation, vol. 2021, 6682657 . https://doi.org/10.1155/2021/6682657
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795b2bce1370ea9d46c956765f879ac8
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3
Abstract 1342: Development and preclinical evaluation of unique first-in-class small molecule inhibitors of the anti-apoptotic protein FLIP
Autor: Jennifer Fox, Catherine A. Higgins, Trevor Perrior, Declan Doherty, Daniel B. Longley, Jamie Z. Roberts, Tim Harrison, Raymond John Boffey
Publikováno v: Cancer Research. 81:1342-1342
In cancer, evasion of cell death is a fundamental cause of resistance to therapy, prompting the development of therapeutics that reactivate cell death pathways such as Bcl-2 family inhibitors and IAP antagonists. The apoptosis modulator Cellular FLIC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ef167029f19d573e9c35e4fbf8772fc
https://doi.org/10.1158/1538-7445.am2021-1342
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4
Airway Inflammation and Host Responses in the Era of CFTR Modulators
Autor: Daniel F. McAuley, Joseph C. Kidney, Claire J Houston, Michael C. McKelvey, Dermot Linden, Damian G Downey, Shannice Creane, Declan Doherty, Clifford C. Taggart, Karen Keown, Ryan Brown, Sinéad Weldon
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6379, p 6379 (2020)
International Journal of Molecular Sciences
Keown, K, Brown, R, Doherty, D F, Houston, C, McKelvey, M C, Creane, S, Linden, D, McAuley, D F, Kidney, J C, Weldon, S, Downey, D G & Taggart, C C 2020, ' Airway Inflammation and Host Responses in the Era of CFTR Modulators ', International journal of molecular sciences, vol. 21, no. 17 . https://doi.org/10.3390/ijms21176379
The arrival of cystic fibrosis transmembrane conductance regulator (CFTR) modulators as a new class of treatment for cystic fibrosis (CF) in 2012 represented a pivotal advance in disease management, as these small molecules directly target the upstre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c6f796b9931b8715cfb8d433cecda
https://www.mdpi.com/1422-0067/21/17/6379
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7
Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease
Autor: Jolanthe Schatterny, Rebecca Delaney, Angela Frank, Michelle Paulsen, Cliff Taggart, Sinéad Weldon, Marcus A. Mall, Simone Schmidt, Declan Doherty, Matthias Hagner, Ryan Brown, Stephanie Hirtz
Publikováno v: American Journal of Respiratory Cell and Molecular Biology
Brown, R, Paulsen, M, Schmidt, S, Schaterrny, J, Frank, A, Hirtz, S, Delaney, R, Doherty, D, Hagner, M, Taggart, C, Weldon, S & Mall, M A 2020, ' Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease ', American Journal of Respiratory Cell and Molecular Biology, vol. 63, no. 3, pp. 300-309 . https://doi.org/10.1165/rcmb.2018-0359OC
Previous studies demonstrated spontaneous type 2 airway inflammation with eosinophilia in juvenile Scnn1b (sodium channel, non-voltage-gated 1, β-subunit)-transgenic (Scnn1b-Tg) mice with muco-obstructive lung disease. IL-1 receptor (IL-1R) signalin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d5e4b99d5f25ac2172c0d7d009af07
https://pubmed.ncbi.nlm.nih.gov/31600081
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8
The role of whey acidic protein four-disulfide-core proteins in respiratory health and disease
Autor: Clifford C. Taggart, Caoifa M. Dougan, Donna M. Small, Declan Doherty, Sinéad Weldon
Publikováno v: Small, D M, Doherty, D F, Dougan, C M, Weldon, S & Taggart, C C 2017, ' The Role of Whey Acidic Protein Four-Disulfide-Core Proteins in Respiratory Health and Disease ', Biological Chemistry, vol. 398, no. 3, pp. 425-440 . https://doi.org/10.1515/hsz-2016-0262
Members of the whey acidic protein (WAP) or WAP four-disulfide-core (WFDC) family of proteins are a relatively under-explored family of low molecular weight proteins. The two most prominent WFDC proteins, secretory leukocyte protease inhibitor (SLPI)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3a607dca0c74151d119e58aab89e18
https://doi.org/10.1515/hsz-2016-0262
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9
Characterisation of eppin function: expression and activity in the lung
Autor: Donna M. Small, Umar Hamid, Maelíosa T.C. McCrudden, Christopher Irwin, Clifford C. Taggart, Aaron Scott, Arlene Glasgow, Simon R. Carlile, Sinéad Weldon, Daniel F. McAuley, David J. Timson, Cecilia O'Kane, Ryan Brown, Declan Doherty, D. McLean, Malcolm Brodlie, Fionnuala Lundy, J. Stuart Elborn, Michael M. Tunney
Publikováno v: Scott, A, Glasgow, A, Small, D, Carlile, S, McCrudden, M, McLean, D, Brown, R, Doherty, D, Lundy, F, Hamid, U, O'Kane, C, McAuley, D, Brodlie, M, Tunney, M, Elborn, J, Irwin, C, Timson, D, Taggart, C & Weldon, S 2017, ' Characterisation of eppin function: expression and activity in the lung ', European Respiratory Journal, vol. 50, no. 1, 1601937 . https://doi.org/10.1183/13993003.01937-2016
Eppin is a serine protease inhibitor expressed in male reproductive tissues.The aim of this study was to investigate the localisation and regulation of eppin expression in myeloid and epithelial cell lines, and explore its potential role as a multifu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f25a442fa9557cdccb63a4e21f60fa
https://pure.qub.ac.uk/en/publications/characterisation-of-eppin-function-expression-and-activity-in-the-lung(c34f5b23-88e2-4535-babb-4b6c9d3cc9a1).html
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10
Vitamin D receptor agonist EB1089 is a potent regulator of prostatic 'intracrine' metabolism
Autor: Declan Doherty, Edna Patricia Rodriguez, Scarlett Anne Dvorkin, Paul Thompson
Publikováno v: The Prostate. 74:273-285
BACKGROUND A contributing factor to the emergence of castrate resistant prostate cancer (CRPC) is the ability of the tumor to circumvent low circulating levels of testosterone during androgen deprivation therapy (ADT), through the production of “in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af29d49799334cbca27e7491833bf83b
https://doi.org/10.1002/pros.22748
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