D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells.

Autor: Hammon K; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; LIT - Leibniz Institute for Immunotherapy; Regensburg., Renner K; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; LIT - Leibniz Institute for Immunotherapy; Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg., Althammer M; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Voll F; LIT - Leibniz Institute for Immunotherapy; Regensburg., Babl N; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Decking SM; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg., Siska PJ; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Matos C; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Conejo ZEC; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Mendes K; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; Present address: Universidade Católica Portuguesa, Center for Interdisciplinary Research in Health (CIIS), Institute of Health Sciences (ICS); Viseu., Einwag F; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Siegmund H; Institute of Pathology, University of Regensburg; Regensburg., Iberl S; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Berger RS; Institute of Functional Genomics, University of Regensburg; Regensburg., Dettmer K; Institute of Functional Genomics, University of Regensburg; Regensburg., Schoenmehl R; Institute of Pathology, University Medical Center Mannheim, University Heidelberg, Mannheim., Brochhausen C; Institute of Pathology, University of Regensburg; Regensburg, Germany; Institute of Pathology, University Medical Center Mannheim, University Heidelberg, Mannheim., Herr W; Department of Internal Medicine III, University Hospital Regensburg; Regensburg., Oefner PJ; Institute of Functional Genomics, University of Regensburg; Regensburg., Rehli M; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; LIT - Leibniz Institute for Immunotherapy; Regensburg., Thomas S; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; LIT - Leibniz Institute for Immunotherapy; Regensburg., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg; Regensburg, Germany; LIT - Leibniz Institute for Immunotherapy; Regensburg. marina.kreutz@ukr.de.

Publikováno v: Haematologica [Haematologica] 2024 Aug 01; Vol. 109 (8), pp. 2500-2514. Date of Electronic Publication: 2024 Aug 01.

Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment.

Autor: Schoeppe R; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Babl N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Department for Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.; Division of Interventional Immunology, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Schönhammer G; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Siegmund A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Department of Gynecology and Obstetrics, University Hospital Regensburg, Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Oefner PJ; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Frick L; Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg, Regensburg, Germany., Weigert A; Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg, Regensburg, Germany., Jantsch J; Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg, Regensburg, Germany., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Division of Interventional Immunology, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany., Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Department for Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Division of Interventional Immunology, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Jan 19; Vol. 13, pp. 1120194. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).

LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid.

Autor: Decking SM; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.; Department of Gynecology and Obstetrics, University Hospital Regensburg, 93053 Regensburg, Germany., Babl N; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany., Bittner S; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany., Klobuch S; Department of Medical Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Thomas S; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany., Feuerer M; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany., Hoffmann P; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany., Oefner PJ; Institute of Functional Genomics, University of Regensburg, 93053 Regensburg, Germany., Renner K; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany., Kreutz M; LIT-Leibniz Institute for Immunotherapy, 93053 Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 26; Vol. 23 (11). Date of Electronic Publication: 2022 May 26.

Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone.

Autor: Siska PJ; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Babl N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Matos C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Singer K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg., Klitzke J; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schön M; Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Simeth J; Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Köstler J; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany., Siegmund H; Institute of Pathology, University of Regensburg, Regensburg, Germany.; Central Biobank Regensburg, University Hospital and University of Regensburg, Regensburg, Germany., Ugele I; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg., Paulus M; Department of Internal Medicine II., Dietl A; Department of Internal Medicine II., Kolodova K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Steines L; Department of Nephrology., Freitag K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Peuker A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schönhammer G; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Raithel J; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Graf B; Department of Anesthesiology., Geismann F; Department of Internal Medicine II., Lubnow M; Department of Internal Medicine II., Mack M; Department of Nephrology., Hau P; Wilhelm Sander-NeuroOncology Unit and Department of Neurology., Bohr C; Department of Otorhinolaryngology, University Hospital Regensburg, Regensburg., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine., Gessner A; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany., Salzberger B; Department of Infection Prevention and Infectious Diseases, and., Wagner R; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany., Hanses F; Department of Infection Prevention and Infectious Diseases, and.; Emergency Department, University Hospital Regensburg, Regensburg, Germany., Hitzenbichler F; Department of Infection Prevention and Infectious Diseases, and., Heudobler D; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Bavarian Cancer Research Center, Regensburg, Germany., Lüke F; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Pukrop T; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Bavarian Cancer Research Center, Regensburg, Germany., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Wolff D; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Spang R; Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Poeck H; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Hoffmann P; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Jantsch J; Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany., Brochhausen C; Institute of Pathology, University of Regensburg, Regensburg, Germany.; Central Biobank Regensburg, University Hospital and University of Regensburg, Regensburg, Germany., Lunz D; Department of Anesthesiology., Rehli M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany., Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Nov 15; Vol. 131 (22).

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.

Autor: Renner K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, Regensburg, Germany. Electronic address: kathrin.renner-sattler@ukr.de., Bruss C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Schnell A; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Koehl G; Department of Surgery, University Hospital Regensburg, Regensburg, Germany., Becker HM; Division of General Zoology, University of Kaiserslautern, Kaiserslautern, Germany., Fante M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Menevse AN; Regensburg Center for Interventional Immunology, Regensburg, Germany., Kauer N; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Blazquez R; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Hacker L; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Decking SM; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Bohn T; Institute for Immunology, University Medical Center Johannes Gutenberg University (UMC) Mainz, Mainz, Germany., Faerber S; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Evert K; Institute of Pathology, University of Regensburg, Regensburg, Germany., Aigle L; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Amslinger S; Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany., Landa M; Institute of Organic Chemistry, University of Regensburg, Regensburg, Germany., Krijgsman O; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Rozeman EA; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Brummer C; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Siska PJ; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Singer K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Pektor S; Department of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Miederer M; Department of Nuclear Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Peter K; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Gottfried E; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Herr W; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Marchiq I; Institute of Research on Cancer and Aging (IRCAN), CNRS-INSERM-UNS UMR 7284, Nice, France., Pouyssegur J; Institute of Research on Cancer and Aging (IRCAN), CNRS-INSERM-UNS UMR 7284, Nice, France; Department of Medical Biology, Scientific Centre of Monaco (CSM), Monaco., Roush WR; Department of Chemistry, The Scripps Research Institute, Scripps-Florida, Jupiter, FL, USA., Ong S; NanoString Technologies, Seattle, WA, USA., Warren S; NanoString Technologies, Seattle, WA, USA., Pukrop T; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Beckhove P; Regensburg Center for Interventional Immunology, Regensburg, Germany., Lang SA; Department of General and Visceral Surgery, Medical Center, Faculty of Medicine University of Freiburg, Freiburg, Germany., Bopp T; Institute for Immunology, University Medical Center Johannes Gutenberg University (UMC) Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI), UMC Mainz, Mainz, Germany; University Cancer Center Mainz, UMC Mainz, Mainz, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Blank CU; Department Medical Oncology and Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Cleveland JL; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Oefner PJ; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, Regensburg, Germany., Selby M; Bristol-Myers Squibb, Redwood City, CA, USA., Kreutz M; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, Regensburg, Germany.

Publikováno v: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 135-150.e9.