Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth.

Autor: Wagh K; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Kreider EF; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Li Y; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Barbian HJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Learn GH; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Giorgi E; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Hraber PT; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Decker TG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Smith AG; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Gondim MV; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Gillis L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Wandzilak J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Chuang GY; Vaccine Research Center, NIH, Bethesda, MD 20892, USA., Rawi R; Vaccine Research Center, NIH, Bethesda, MD 20892, USA., Cai F; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Pellegrino P; Center for Sexual Health & HIV Research, Mortimer Market Centre, London WC1E 6JB, UK., Williams I; Center for Sexual Health & HIV Research, Mortimer Market Centre, London WC1E 6JB, UK., Overbaugh J; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Gao F; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Kwong PD; Vaccine Research Center, NIH, Bethesda, MD 20892, USA., Haynes BF; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA., Shaw GM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Borrow P; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Hahn BH; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bhahn@pennmedicine.upenn.edu., Korber B; Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address: btk@lanl.gov.

Publikováno v: Cell reports [Cell Rep] 2018 Oct 23; Vol. 25 (4), pp. 893-908.e7.