Peptide-guided JC polyomavirus-like particles specifically target bladder cancer cells for gene therapy

Autor: Wei-Hong Lai, Chiung-Yao Fang, Ming-Chieh Chou, Mien-Chun Lin, Cheng-Huang Shen, Chun-Nun Chao, Yeong‐Chin Jou, Deching Chang, Meilin Wang

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract The ultimate goal of gene delivery vectors is to establish specific and effective treatments for human diseases. We previously demonstrated that human JC polyomavirus (JCPyV) virus-like particles (VLPs) can package and deliver exogenous DNA

Externí odkaz: https://doaj.org/article/59cd74bb6c5149f8a96541e47988ae7e

Progressive Multifocal Leukoencephalopathy in an Immunocompetent Taiwanese Patient

Autor: Yung-Yee Chang, Min-Yu Lan, Cheng-Huei Peng, Hsiu-Shan Wu, DeChing Chang, Jia-Shou Liu

Publikováno v: Journal of the Formosan Medical Association, Vol 106, Iss 2, Pp S60-S64 (2007)

Progressive multifocal leukoencephalopathy (PML) is a deadly demyelinating brain disease caused by JC virus (JCV). Genomic analysis of viral isolates in these cases often shows prototype-like JCV and its variants, which is a virulent strain compared

Externí odkaz: https://doaj.org/article/f9b2a44fb0054a9aa01bf76214e97e21

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model

Autor: Shih Han Chen, Sara Collins, Shu-Fen Wu, Jui Ming Sun, Deching Chang, Weijun Wang, Hao Fang Chang, Thomas C. Chen, Bing Mao Chen, Yin Che Lu, Chien-Kuo Tai, Sheng Che Lin, Noriyuki Kasahara, Hsin Ell Wang

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 4
International journal of molecular sciences, vol 21, iss 4
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1433 (2020)

Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo. To avoid receptor interference and enab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429231c40a824996e94b98b192450c4d

Inhibition of human lung adenocarcinoma growth and metastasis by JC polyomavirus-like particles packaged with an SP-B promoter-driven CD59-specific shRNA

Autor: Deching Chang, Cheng-Huang Shen, Mien-Chun Lin, Meilin Wang

Publikováno v: Clinical science (London, England : 1979). 133(21)

Lung cancer ranks first in both incidence and mortality and is a major health concern worldwide. Upon recognition of specific antigens on tumor cells, complement-dependent cytotoxicity (CDC) is activated, arresting cell growth or inducing apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495d31292cf248a5c7fa3fac7f1f8e6f
https://pubmed.ncbi.nlm.nih.gov/31693732

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

Autor: Yi-Ting Wang, Deching Chang, Shu-Fen Wu, Cheng-Huang Shen, Michael W.Y. Chan, Ming-Hsuan Tsai, Pi-Che Chen, Cheng-Da Hsu, Hsiao-Yen Hsieh, Szu-Shan Ch, Chang-Te Lin, Chia-Ming Yeh, Ru-Inn Lin, Chun-Liang Tung, Yeong-Chin Jou, Wen-Yu Huang

Publikováno v: Oncotarget

// Chia-Ming Yeh 1,2,* , Pi-Che Chen 3,* , Hsiao-Yen Hsieh 2,5 , Yeong-Chin Jou 3 , Chang-Te Lin 3 , Ming-Hsuan Tsai 1 , Wen-Yu Huang 1,2 , Yi-Ting Wang 1,2 , Ru-Inn Lin 1,6 , Szu-Shan Chen 1,2 , Chun-Liang Tung 4 , Shu-Fen Wu 1,2 , De-Ching Chang 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad9dcee6bde378b5c95fd9609b7c9c8
http://europepmc.org/articles/PMC4745746