Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo .

Autor: Jones JH; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Xin Z; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Himmelbauer M; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Dechantsreiter M; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Enyedy I; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hedde J; Acute Neurology Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Fang T; Acute Neurology Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Coomaraswamy J; Movement Disorders Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., King KW; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Murugan P; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Santoro JC; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hesson T; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Walther DM; Chemical Biology and Proteomics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Wei R; Chemical Biology and Proteomics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Zheng F; Technical Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Marcotte DJ; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Spilker K; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kumar PR; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Liu Y; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gilfillan R; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gonzalez-Lopez de Turiso F; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Oct 28; Vol. 64 (20), pp. 15402-15419. Date of Electronic Publication: 2021 Oct 15.

Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.

Autor: Ma B; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA. Electronic address: bin.ma@biogen.com., Lucas B; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Capacci A; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Lin EY; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Jones JH; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Dechantsreiter M; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Enyedy I; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Marcotte D; Biophysics, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Xiao G; Drug Metabolism & Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Li B; Research & Early Development, Biogen, 225 Binney Street, Cambridge, MA 02142, USA., Richter K; Research & Early Development, Biogen, 225 Binney Street, Cambridge, MA 02142, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Feb 15; Vol. 30 (4), pp. 126852. Date of Electronic Publication: 2019 Dec 02.

Carrier-Mediated Delivery of Low-Molecular-Weight N -Containing Drugs across the Blood–Brain Barrier or the Blood–Retinal Barrier Using the Proton-Coupled Organic Cation Antiporter.

Autor: Tashima, Toshihiko¹ tashima_lab@yahoo.co.jp

Publikováno v: Future Pharmacology. Dec2023, Vol. 3 Issue 4, p742-762. 21p.

Quantum chromodynamics and leptoproduction as a large p process.

Autor: Dechantsreiter, M., Halzen, F., Scott, D.

Publikováno v: Zeitschrift für Physik. C, Particles & Fields; 1981, Vol. 8 Issue 1, p85-90, 6p

Quantum chromodynamics and leptoproduction as a largepT process

Autor: Dechantsreiter, M., Halzen, F., Scott, D. M.

Publikováno v: Zeitschrift für Physik C Particles and Fields; March 1981, Vol. 8 Issue: 1 p85-90, 6p