3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies

Autor: Huaikai Shi, Emma M. Rath, Ruby C. Y. Lin, Kadir Harun Sarun, Candice Julie Clarke, Brian C. McCaughan, Helen Ke, Anthony Linton, Kenneth Lee, Sonja Klebe, Joanneke Maitz, Kedong Song, Yiwei Wang, Steven Kao, Yuen Yee Cheng

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Traditional studies using cancer cell lines are often performed on a two-dimensional (2D) cell culture model with a low success rate of translating to Phase I or Phase II clinical studies. In comparison, with the advent of developments three-dimensio

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Mesenchymal cells support the early retention of primary alveolar type 2 cells on acellular mouse lung scaffolds.

Autor: Taniguchi D; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada.; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan., Ahmadipour M; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada.; Institute of Medical Sciences, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A8, Canada., Eiliazadeh AL; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada., Duchesneau P; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada., Nagayasu T; Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan., Haykal S; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada.; Institute of Medical Sciences, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A8, Canada.; Division of Plastic & Reconstructive Surgery, Department of Surgery, University of Toronto, 200 Elizabeth Street 8N-869, Toronto, ON, M5G2P7, Canada., Karoubi G; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada.; Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, M5S3G8, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S1A8, Canada., Waddell TK; Latner Thoracic Research Laboratories, DIvision of Thoracic Surgery, 101 College St. 2-817, Toronto, ON, M5G1L7, Canada.; Institute of Medical Sciences, University of Toronto, 27 King's College Cir, Toronto, ON, M5S1A8, Canada.; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S3G9, Canada.

Publikováno v: Regenerative therapy [Regen Ther] 2023 Dec 20; Vol. 25, pp. 92-100. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2024).