Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Debra Yager"'
Autor:
Chris De Jonghe, Cynthia Zehr, Debra Yager, Cristian-Mihail Prada, Steven Younkin, Lydia Hendriks, Christine Van Broeckhoven, Christopher B. Eckman
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 4, Pp 281-286 (1998)
Mutations in theamyloid β precursor protein(APP) gene cosegregate with autosomal dominant Alzheimer disease (AD). Brain pathology of AD is characterized by amyloid deposition in senile plaques and by neurofibrillary tangles. Amyloid deposits in AD b
Externí odkaz:
https://doaj.org/article/d23b7d6b0c164179bfd273279372be99
Autor:
Thomas B. Ladd, Bernadette Cusack, Debra Yager, Dominic M. Walsh, Thomas Kukar, Ghulam M. Maharvi, Robert Chapman, Alfred T. Welzel, Vijayaraghavan Rangachari, Christopher B. Eckman, Wenjuan Ye, Christophe Verbeeck, Sarah A. Sagi, Maralyssa Bann, Todd E. Golde, Robert W. Price, Terrone L. Rosenberry, Boris Schmidt, Justin W. Torpey, Brent Healy, Barbara A. Cottrell, Karen Jansen-West, Jason L. Eriksen, Edward H. Koo, Abdul H. Fauq, Patrick C. Fraering, Rajeshwar Narlawar, Michael S. Wolfe, Brenda D. Moore
Publikováno v:
Nature. 453:925-929
Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf54ddc8ee902f121fabb607fd45858
https://doi.org/10.1038/nature07055
https://doi.org/10.1038/nature07055
Autor:
Linda H. Younkin, Debra Yager, Sanjay Asthana, Francine Parfitt, Mike Hutton, Matt Baker, Steve Younkin, Nilufer Ertekin-Taner, Neil Graff-Radford
Publikováno v:
Neurology. 70:596-606
Objective: Plasma Aβ levels are elevated in early-onset Alzheimer disease (AD) caused by autosomal dominant mutations. Our objective was to determine whether similar genetic elevations exist in late-onset AD (LOAD). Methods: We measured plasma Aβ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de6ea53a413f40097fe414def13a4a4
https://doi.org/10.1212/01.wnl.0000278386.00035.21
https://doi.org/10.1212/01.wnl.0000278386.00035.21
Autor:
Debra Yager, Donna L. McPhie, Christopher B. Eckman, Rachael L. Neve, Todd E. Golde, Justin B Brant
Publikováno v:
Molecular Brain Research. 97:103-113
The amyloid precursor protein (APP) is cleaved by two enzymes, beta-secretase and gamma-secretase, to generate the pathological amyloid beta (Abeta) peptide. Expression of familial Alzheimer's disease (FAD) mutants of APP in primary neurons causes bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995691d664d2627bc6b7eb0ef968475b
https://doi.org/10.1016/s0169-328x(01)00294-7
https://doi.org/10.1016/s0169-328x(01)00294-7
Autor:
Debra Yager, S. J. Haugabook, Todd E. Golde, Christopher B. Eckman, Elizabeth A. Eckman, Steve Younkin
Publikováno v:
Journal of Neuroscience Methods. 108:171-179
Evidence gathered over the last two decades suggests that beta amyloid (Abeta), the predominant proteinaceous component of senile plaques, plays an early and critical role in the etiology and pathogenesis of Alzheimer's disease (AD). Thus, it is reas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7b1eadbf0cd23d777d0036c99b6949
https://doi.org/10.1016/s0165-0270(01)00388-0
https://doi.org/10.1016/s0165-0270(01)00388-0
Autor:
Michael R. Nichols, Kumar Sambamurti, Debra Yager, Lisa M. Kopcho, Jovita Marcinkeviciene, Terrone L. Rosenberry, Luisa Onstead, Christopher B. Eckman, Robert A. Copeland, William D. Mallender
Publikováno v:
Molecular Pharmacology. 59:619-626
The beta-site amyloid precursor protein-cleaving enzyme (BACE) cleaves the amyloid precursor protein to produce the N terminus of the amyloid beta peptide, a major component of the plaques found in the brains of Alzheimer's disease patients. Sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075313cc13d2c3a3fe882c0b220d0352
https://doi.org/10.1124/mol.59.3.619
https://doi.org/10.1124/mol.59.3.619
Autor:
Mary Seeger, Christopher B. Eckman, Debra Yager, Michael K. Lee, Gopal Thinakaran, Steven G. Younkin, Neal G. Copeland, Grace Kim, Frances Davenport, Sangram S. Sisodia, Rong Wang, Sam Gandy, Hilda H. Slunt, Donald L. Price, Nancy A. Jenkins, Cristian Mihail Prada, Tamara Ratovitsky, Sophia Seekins, David R. Borchelt, Allan I. Levey
Publikováno v:
Neuron. 17(5):1005-1013
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Abeta1-42(43)/Abeta1-40 ratio in the conditioned media of independent N2a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cfbdd42dc011cb37d559eddf05d08d
Autor:
Dennis J. Selkoe, Wesley F. Austin, Timothy D. McKee, Steffen Phillip Creaser, Christopher B. Eckman, Debra Yager, Jon Clardy, Mark A. Findeis, Patrick C. Fraering, Frank C. Schroeder, Rong Wang
Publikováno v:
ACS chemical neuroscience
A screen of a library of synthetic drugs and natural product extracts identified a botanical extract that modulates the processing of amyloid precursor protein (APP) in cultured cells to produce a lowered ratio of amyloid-beta peptide (1-42) (Aβ42)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0849423b34e751bb0655067e42fe7c
https://pubmed.ncbi.nlm.nih.gov/23205187
https://pubmed.ncbi.nlm.nih.gov/23205187
Autor:
A. Hanna, Christopher Janus, Elizabeth A. Eckman, Christopher B. Eckman, Patrick Horne, Debra Yager
Publikováno v:
Genes, brain, and behavior. 8(7)
The relationship between amyloid beta and cognitive dysfunction in mouse models of Alzheimer's disease has been evaluated predominantly with the spatial reference memory version of the water maze task. However, as Alzheimer's disease encompasses decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504bf492168c138732cfc39e3682874c
https://pubmed.ncbi.nlm.nih.gov/19531156
https://pubmed.ncbi.nlm.nih.gov/19531156
Autor:
Nitin D. Mehta, Mike Hutton, John Hardy, Debra Yager, Sunny Sanders, Karen Duff, Chris Eckman, Lawrence M. Refolo, Jordi Pérez-Tur, Steve Younkin
Publikováno v:
Annals of Neurology. 43:256-258
Mutations in the presenilin 1 (PS1) gene on chromosome 14 are a major cause of autosomal dominant, early-onset Alzheimer's disease. Here, we show that transfecting cells with several mutant, but not wild-type, PS1 cDNAs alters the processing of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9eba5fc6c8d8be10b2f61e0591678c
https://doi.org/10.1002/ana.410430217
https://doi.org/10.1002/ana.410430217