Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Debra Toiber"'
Autor:
Dmitrii Smirnov, Ekaterina Eremenko, Daniel Stein, Shai Kaluski, Weronika Jasinska, Claudia Cosentino, Barbara Martinez-Pastor, Yariv Brotman, Raul Mostoslavsky, Ekaterina Khrameeva, Debra Toiber
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The SIRT6 deacetylase has been implicated in DNA repair, telomere maintenance, glucose and lipid metabolism and, importantly, it has critical roles in the brain ranging from its development to neurodegeneration. Here, we combined transcripto
Externí odkaz:
https://doaj.org/article/f5472176f4364d77aa8dcdf18cecc6e1
Autor:
L Francisco Sanhueza Salas, Alfredo García-Venzor, Natalia Beltramone, Claudia Capurro, Debra Toiber, Dafne Magalí Silberman
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Retinal Müller glial cells (MGs) are among the first to demonstrate metabolic changes during retinal disease and are a potential source of regenerative cells. In response to a harmful stimulus, they can dedifferentiate acquiring neural stem cells pr
Externí odkaz:
https://doaj.org/article/e4d2377e8b4d44eaba3b50e197784901
Autor:
Alfredo Garcia-Venzor, Debra Toiber
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
During an organism’s lifespan, two main phenomena are critical for the organism’s survival. These are (1) a proper embryonic development, which permits the new organism to function with high fitness, grow and reproduce, and (2) the aging process,
Externí odkaz:
https://doaj.org/article/3644de60da1d4c3cb2dfe842b5c04aa4
Autor:
Ekaterina Eremenko, Anastasia Golova, Daniel Stein, Monica Einav, Ekaterina Khrameeva, Debra Toiber
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100643- (2021)
Summary: The organization of chromatin structure plays a crucial role in gene expression, DNA replication, and repair. Chromatin alterations influence gene expression, and modifications could be associated with genomic instability in the cells during
Externí odkaz:
https://doaj.org/article/c92e1ebf26644423be94ea7e8551b60e
Publikováno v:
Behavioral and Brain Functions, Vol 15, Iss 1, Pp 1-9 (2019)
Abstract Background Signs of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference were reported in adult m
Externí odkaz:
https://doaj.org/article/cd6e28cdbb01434b95669d2bf7c5e35b
Autor:
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Publikováno v:
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://doaj.org/article/8ec54c204be64101928f8e9ebb75bef6
Autor:
Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular home
Externí odkaz:
https://doaj.org/article/6ccf7a040ef74caca19da73a1a727ed2
Autor:
Shai Kaluski, Miguel Portillo, Antoine Besnard, Daniel Stein, Monica Einav, Lei Zhong, Uwe Ueberham, Thomas Arendt, Raul Mostoslavsky, Amar Sahay, Debra Toiber
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3052-3062 (2017)
The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that bra
Externí odkaz:
https://doaj.org/article/2d6330c2933042aeba10c132fa2db6f9
Autor:
Daniel Stein, Debra Toiber
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 9, Pp 1441-1442 (2017)
Externí odkaz:
https://doaj.org/article/99f63c8a75874bebb6949449fa2b11e9
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 348-359 (2010)
Down syndrome (DS) associates with impaired brain functions, but the underlying mechanism(s) are yet unclear. The “gene dosage” hypothesis predicts that in DS, overexpression of a single gene can impair multiple brain functions through a signal a
Externí odkaz:
https://doaj.org/article/bb4fa0e910b141f4a2e44973cae8913f