Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Debra T. Chao"'
Autor:
Shiming Ye, Melvin I. Fox, Nicole A. Belmar, Mien Sho, Debra T. Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F. Keller, Gary C. Starling, Patricia A. Culp
Publikováno v:
Journal of Immunology Research, Vol 2017 (2017)
Enavatuzumab is a humanized IgG1 anti-TWEAK receptor monoclonal antibody that was evaluated in a phase I clinical study for the treatment of solid malignancies. The current study was to determine whether and how myeloid effector cells were involved i
Externí odkaz:
https://doaj.org/article/14443094aa82421d8333bf5917c19588
Autor:
James W. Purcell, Han K. Kim, Sonia G. Tanlimco, Minhtam eDoan, Melvin eFox, Peter eLambert, Debra T. Chao, Mien eSho, Keith E. Wilson, Gary C. Starling, Patricia A. Culp
Publikováno v:
Frontiers in Immunology, Vol 4 (2014)
TweakR is a TNF receptor family member, whose natural ligand is the multifunctional cytokine TWEAK. The growth inhibitory activity observed following TweakR stimulation in certain cancer cell lines and the overexpression of TweakR in many solid tumor
Externí odkaz:
https://doaj.org/article/2743f432050840d09fe948a8877e8326
Autor:
Fabrice Barlesi, Steven Kao, Philippe A Cassier, Hua Fang, Frances Fan, Kathryn Allaire, Shiming Ye, Debra T Chao, William R Henner, Joel S Hayflick, Michael A McDevitt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Background CD40 agonist immunotherapy can potentially license antigen-presenting cells to promote antitumor T-cell activation and re-educate macrophages to destroy tumor stroma. Systemic administration of CD40 agonists has historically been associate
Externí odkaz:
https://doaj.org/article/20dbdf5be81c4b86b9fc3af9b764237c
Autor:
Debra T. Chao, Diane Hollenbaugh, Patricia Culp, Alan F. Wahl, Yuni Fang, Catherine Zhang, John Harlan, Danying Song, Marc Lake, Jean Cabel, Ramesh Iyer, Han Kim, Yoshiko Akamatsu, Mien Sho, Siu Sze Tan, Donghee Choi, Nicole A. Belmar, Diane Cohen, Shiming Ye
PC3 cells stably expressing different levels of MSLN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fe02840c673483123e5f0929841c42
https://doi.org/10.1158/2326-6066.22542501.v1
https://doi.org/10.1158/2326-6066.22542501.v1
Autor:
Debra T. Chao, Diane Hollenbaugh, Patricia Culp, Alan F. Wahl, Yuni Fang, Catherine Zhang, John Harlan, Danying Song, Marc Lake, Jean Cabel, Ramesh Iyer, Han Kim, Yoshiko Akamatsu, Mien Sho, Siu Sze Tan, Donghee Choi, Nicole A. Belmar, Diane Cohen, Shiming Ye
Binding affinity of LB-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba6cdbda7ccf3457705f52ec15cef87
https://doi.org/10.1158/2326-6066.22542498
https://doi.org/10.1158/2326-6066.22542498
Autor:
Debra T. Chao, Diane Hollenbaugh, Patricia Culp, Alan F. Wahl, Yuni Fang, Catherine Zhang, John Harlan, Danying Song, Marc Lake, Jean Cabel, Ramesh Iyer, Han Kim, Yoshiko Akamatsu, Mien Sho, Siu Sze Tan, Donghee Choi, Nicole A. Belmar, Diane Cohen, Shiming Ye
Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence of a tumor antigen and had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694bf4988a8ed4f7c7f07adbc8095610
https://doi.org/10.1158/2326-6066.c.6549954.v1
https://doi.org/10.1158/2326-6066.c.6549954.v1
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
Efficacy and pharmacodynamics analysis of anti-CD137 in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a80e5785dfed25dfb55c2ef1b50324
https://doi.org/10.1158/1535-7163.22520673.v1
https://doi.org/10.1158/1535-7163.22520673.v1
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
Binding kinetics of anti-CD137 measured by Biacore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adee88711469c8b488cfa7f95e6071f
https://doi.org/10.1158/1535-7163.22520667.v1
https://doi.org/10.1158/1535-7163.22520667.v1
Autor:
Yoshiko Akamatsu, Hamsell M. Alvarez, Diane Hollenbaugh, Debra T. Chao, David B. Powers, Charles M. Forsyth, Josue Samayoa, Mengli Xiong, Vivian Zhao, Belinda Cairns, Mien Sho, Li Zhou, Enrico DiGiammarino, Siu Sze Tan, Melvin Fox, Archana Thakur, Zhenghai Xu, Sun K. Ho
CD137 (TNFRSF9, 4-1BB) agonist antibodies (mAb) have demonstrated potent antitumor activity with memory response while causing hepatotoxicity in mouse models. In clinical trials, the degrees of liver toxicity of anti-CD137 vary from grade 4 transamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793ce8580dc06cb588737a5a4dcecf4c
https://doi.org/10.1158/1535-7163.c.6542724
https://doi.org/10.1158/1535-7163.c.6542724
Autor:
Debra T. Chao, Eric D. Hsi, Susan E. Morgan-Lappe, Kurt Gish, Diane Hollenbaugh, Sasmita Mishra, Joann P. Palma, Dong Zhang, Josue Samayoa, Subashri Kumar, Thomas McGonigal, Kelly Foster, Rick Powers, Tamar Uziel, Lisa Durkin, Mien Sho, Melvin Fox, Jonathan Hickson, Sonia G. Tanlimco, James W. Purcell
Cross species binding and tolerability of ABBV-085.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982f60403077744d5cfc6fa3a2c003e3
https://doi.org/10.1158/0008-5472.22419597.v1
https://doi.org/10.1158/0008-5472.22419597.v1