Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Debra Rimmington"'
Autor:
John W. R. Kincaid, Debra Rimmington, John A. Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The hormone GDF15 is secreted in response to cellular stressors. Metformin elevates circulating levels of GDF15, an action important for the drug’s beneficial effects on body weight. Metformin can also inhibit mammalian respiratory complex
Externí odkaz:
https://doaj.org/article/36d415474a95447299258e0b0a1879b6
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A. Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A. Brighton, Marcella Ma, Brian Y. H. Lam, Anthony P. Coll, Stephen O’Rahilly, Frank Reimann, Fiona M. Gribble
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Even though metformin is widely used to treat type2 diabetes, reducing glycaemia and body weight, the mechanisms of action are still elusive. Recent studies have identified the gastrointestinal tract as an important site of action. Here we u
Externí odkaz:
https://doaj.org/article/3277fbedd1ef4a0488a75dc21d27c7a7
Autor:
Georgina K.C. Dowsett, Brian Y.H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101240- (2021)
Objective: The area postrema (AP) and nucleus tractus solitarius (NTS) located in the hindbrain are key nuclei that sense and integrate peripheral nutritional signals and consequently regulate feeding behaviour. While single-cell transcriptomics have
Externí odkaz:
https://doaj.org/article/b936b51bf93846b983c2dbc7b36f2da8
Autor:
Zhengzheng S Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E Vancollie, Ximena Ibarra-Soria, Helen V Firth, Debra Rimmington, I Sadaf Farooqi, Christopher J Lelliott, Steven C Munger, Stephen O'Rahilly, Anne C Ferguson-Smith, Anthony P Coll, Darren W Logan
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008916 (2020)
Some imprinted genes exhibit parental origin specific expression bias rather than being transcribed exclusively from one copy. The physiological relevance of this remains poorly understood. In an analysis of brain-specific allele-biased expression, w
Externí odkaz:
https://doaj.org/article/d7e4936735004c35b3e6c52483f730c4
Autor:
Brian Y.H. Lam, Irene Cimino, Joseph Polex-Wolf, Sara Nicole Kohnke, Debra Rimmington, Valentine Iyemere, Nicholas Heeley, Chiara Cossetti, Reiner Schulte, Luis R. Saraiva, Darren W. Logan, Clemence Blouet, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 383-392 (2017)
Objective: Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. Methods: Using single cell RNA sequencin
Externí odkaz:
https://doaj.org/article/420acb59b9a143a7bd33fe340d1f7af7
Autor:
Y.C. Loraine Tung, Pawan Gulati, Che-Hsiung Liu, Debra Rimmington, Rowena Dennis, Marcella Ma, Vladimir Saudek, Stephen O'Rahilly, Anthony P. Coll, Giles S.H. Yeo
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 287-298 (2015)
Objective: Loss of function FTO mutations significantly impact body composition in humans and mice, with Fto-deficient mice reported to resist the development of obesity in response to a high-fat diet (HFD). We aimed to further explore the interactio
Externí odkaz:
https://doaj.org/article/d16fdc78041448f683f99844d85e3079
Autor:
Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003166 (2013)
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunt
Externí odkaz:
https://doaj.org/article/3524d8cdac74414d80af2322999a4376
Autor:
Anthony P. Coll, MN Bedenbaugh, DT Porter, David H. Rowitch, John R. B. Perry, D A van Heel, X Dai, Rachel N. Lippert, Debra Rimmington, A. L. Gonçalves Soares, Felix R. Day, Duckett K, Patrick Sweeney, Zhaoyang Xu, Ahsan Nabi Khan, Hilary C. Martin, John Tadross, Roger D. Cone, Brian Y.H. Lam, Klj Ellacott, Richard B. Simerly, J Rosmaninho-Salgado, Alice E. Williamson, Gkc Dowsett, Sarah Finer, Irene Cimino, Giles S.H. Yeo, Audrey Melvin, Kara Rainbow, Claudia Langenberg, Stephen O'Rahilly, Nicholas J. Wareham, Katherine Ridley, Richard C. Trembath, Staffan Holmqvist, Sophie Buller, N J Timpson, Kaitlin H Wade, Ken K. Ong, Elena G. Bochukova
Publikováno v:
Nature
2021, ' MC3R links nutritional state to childhood growth and the timing of puberty ', Nature, vol. 599, no. 7885, pp. 436-441 . https://doi.org/10.1038/s41586-021-04088-9
2021, ' MC3R links nutritional state to childhood growth and the timing of puberty ', Nature, vol. 599, no. 7885, pp. 436-441 . https://doi.org/10.1038/s41586-021-04088-9
The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4 receptor (MC4R) to con
Autor:
Minoru Takaoka, John A. Tadross, Ali Al-Hadithi, Rocío Villena-Gutiérrez, Jasper Tromp, Shazia Absar, Marcus Au, James Harrison, Anthony P. Coll, Stefan J. Marciniak, Debra Rimmington, Eduardo Oliver, Borja Ibáñez, Adriaan A. Voors, Stephen O’Rahilly, Ziad Mallat, Jane C. Goodall
Heart failure and associated cachexia is an unresolved and important problem. We report a new model of severe heart failure that consistently results in cachexia. Mice lacking the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec273ed5489a7538e35e97c7a1cb25ac
https://doi.org/10.1101/2022.09.06.506633
https://doi.org/10.1101/2022.09.06.506633