Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Debra Parchaliuk"'
Autor:
Sarah J. Medina, Rhiannon L. C. H. Huzarewich, Debra Parchaliuk, Catherine Robertson, Stephanie A. Booth
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 74:1504-1520
Prion replication in the periphery precedes neuroinvasion in many experimental rodent scrapie models, and in natural sheep scrapie and chronic wasting disease (CWD) in cervids. Prions propagate in the germinal centers of secondary lymphoid organs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c48f026dce8aff0c6a3da2c014dd0d
https://doi.org/10.1080/15287394.2011.618979
https://doi.org/10.1080/15287394.2011.618979
Autor:
Stefanie Czub, J. David Knox, Michael Stobart, Sharon L.R. Simon, Debra Parchaliuk, Lise Lamoureux, R. E. J. Mitchel, Rebecca Mantha, Kathy L. Frost, Douglas R. Boreham, Margot Plews, Heather Wyatt
Publikováno v:
Free Radical Biology and Medicine. 49:1417-1421
Previously, it has been demonstrated that an "adaptive response" that includes the prevention, repair, and removal of oxidative damage can be evoked by radiation at dose rates substantially lower than those at which risks have been observed. The exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd6596659497fbd8790d898ca4a25b9
https://doi.org/10.1016/j.freeradbiomed.2010.07.025
https://doi.org/10.1016/j.freeradbiomed.2010.07.025
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 72:1075-1082
Prion and Alzheimer's diseases are two apparently distinct disorders; however, the two proteinaceous species implicated in disease progression share a number of common features. In prion diseases a beta-rich conformer of the prion protein is the key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62ff893e1c43b388b864cd413d01fed
https://doi.org/10.1080/15287390903084561
https://doi.org/10.1080/15287390903084561
Autor:
Garrett Sorensen, Debra Parchaliuk, Sarah J. Medina, Laura Landry, Qingzhong Kong, Jingjing Liang, Shenghai Huang, Meiling Wang, Stephanie A. Booth
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 201 (2009)
BMC Genomics
BMC Genomics
BackgroundWe have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. The preferential accumulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d48a98fa0e6e21ecf1332d771d14fc
http://www.biomedcentral.com/1471-2164/10/201
http://www.biomedcentral.com/1471-2164/10/201
Autor:
Clark Phillipson, Garrett Sorensen, Debra Parchaliuk, Stephanie A. Booth, Catherine Robertson, Sarah J. Medina
Publikováno v:
BMC Genomics
BMC Genomics, Vol 9, Iss 1, p 114 (2008)
BMC Genomics, Vol 9, Iss 1, p 114 (2008)
Background Prion infection results in progressive neurodegeneration of the central nervous system invariably resulting in death. The pathological effects of prion diseases in the brain are morphologically well defined, such as gliosis, vacuolation, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d6298c5000040dbdfda1c86c61110a
Autor:
Jillian L. LeMaistre, J. David Knox, Jozef Lazar, Richard Rubenstein, Michael Stobart, Sharon L R Simon, Debra Parchaliuk
Publikováno v:
Molecular Neurodegeneration, Vol 2, Iss 1, p 5 (2007)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background The pathological hallmarks of transmissible spongiform encephalopathy (TSE) diseases are the deposition of a misfolded form of a host-encoded protein (PrPres), marked astrocytosis, microglial activation and spongiosis. The development of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc59d6d5a40ef0b13b273769c5a99cb