Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Debra Nickischer"'
Autor:
Ann F. Hoffman, Debra Nickischer, Wienand A. Omta, David F. Gebhard, John Nolan, Judi Wardwell-Swanson, Sam Cooper, Myles Fennell, Sharon Presnell
Publikováno v:
Assay and drug development technologies. 16(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fc14dd7648689f86ca2cb608855b9a
https://pubmed.ncbi.nlm.nih.gov/29345980
https://pubmed.ncbi.nlm.nih.gov/29345980
Autor:
Debra, Nickischer, Lisa, Elkin, Normand, Cloutier, Jonathan, O'Connell, Martyn, Banks, Andrea, Weston
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1683
Within the Drug Discovery industry, there is a growing recognition of the value of high content screening (HCS), particularly as researchers aim to screen compounds and identify hits using more physiologically relevant in vitro cell-based assays. Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d027fbc415718506ef93b476f0f615b4
https://pubmed.ncbi.nlm.nih.gov/29082493
https://pubmed.ncbi.nlm.nih.gov/29082493
Autor:
Martyn Banks, Andrea D. Weston, Lisa Elkin, Jonathan O’Connell, Debra Nickischer, Normand J. Cloutier
Publikováno v:
Methods in Molecular Biology ISBN: 9781493973552
Within the Drug Discovery industry, there is a growing recognition of the value of high content screening (HCS), particularly as researchers aim to screen compounds and identify hits using more physiologically relevant in vitro cell-based assays. Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2773afaf4e6bf70a4e60829b2e3d6bde
https://doi.org/10.1007/978-1-4939-7357-6_11
https://doi.org/10.1007/978-1-4939-7357-6_11
Publikováno v:
Current Chemical Genomics and Translational Medicine
Microtubules are important components of the cellular cytoskeleton that play roles in various cellular processes such as vesicular transport and spindle formation during mitosis. They are formed by an ordered organization of α-tubulin and β-tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6724ff2d9b75340a83579ab42268b466
https://doi.org/10.2174/2213988501408010016
https://doi.org/10.2174/2213988501408010016
Autor:
O Joseph, Trask, Debra, Nickischer, Audrey, Burton, Rhonda Gates, Williams, Ramani A, Kandasamy, Patricia A, Johnston, Paul A, Johnston
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 565
The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38d148566232e70a4e23c23881f8baf8
https://pubmed.ncbi.nlm.nih.gov/19551362
https://pubmed.ncbi.nlm.nih.gov/19551362
Autor:
Paul A. Johnston, Patricia A. Johnston, Ramani Kandasamy, O. Joseph Trask, Rhonda Gates Williams, Audrey Burton, Debra Nickischer
Publikováno v:
Methods in Molecular Biology ISBN: 9781603272575
The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33ba452c4b22feb30354350df88b992b
https://doi.org/10.1007/978-1-60327-258-2_8
https://doi.org/10.1007/978-1-60327-258-2_8
Autor:
Debra, Nickischer, Carmen, Laethem, Oscar J, Trask, Rhonda Gates, Williams, Ramani, Kandasamy, Patricia A, Johnston, Paul A, Johnston
Publikováno v:
Methods in enzymology. 414
This chapter describes the development and implementation of three independent imaging assays for the major mitogen-activated protein kinase (MAPK) signaling modules: p38, JNK, and ERK. There are more than 500 protein kinases encoded in the human gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b508907b0ee872819b64bcfbdd235be3
https://pubmed.ncbi.nlm.nih.gov/17110204
https://pubmed.ncbi.nlm.nih.gov/17110204
Autor:
Rhonda Gates, Williams, Ramani, Kandasamy, Debra, Nickischer, Oscar J, Trask, Carmen, Laethem, Patricia A, Johnston, Paul A, Johnston
Publikováno v:
Methods in enzymology. 414
This chapter describes the generation and characterization of a stable MK2-EGFP expressing HeLa cell line and the subsequent development of a high-content imaging assay on the Cellomics ArrayScan platform to screen for p38 MAPK inhibitors. Mitogen-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a78a9d0062d0dd427a046b32cfa902b
https://pubmed.ncbi.nlm.nih.gov/17110203
https://pubmed.ncbi.nlm.nih.gov/17110203
Autor:
Oscar J, Trask, Audrey, Baker, Rhonda Gates, Williams, Debra, Nickischer, Ramani, Kandasamy, Carmen, Laethem, Patricia A, Johnston, Paul A, Johnston
Publikováno v:
Methods in enzymology. 414
This chapter describes the conversion and assay development of a 96-well MK2-EGFP translocation assay into a higher density 384-well format high-content assay to be screened on the ArrayScan 3.1 imaging platform. The assay takes advantage of the well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4aed3d61208c2f3622c5e96ffa1d478a
https://pubmed.ncbi.nlm.nih.gov/17110205
https://pubmed.ncbi.nlm.nih.gov/17110205
Autor:
Paul A. Johnston, Patricia A. Johnston, Oscar J. Trask, Carmen Laethem, Debra Nickischer, Rhonda Gates Williams, Ramani Kandasamy
This chapter describes the development and implementation of three independent imaging assays for the major mitogen-activated protein kinase (MAPK) signaling modules: p38, JNK, and ERK. There are more than 500 protein kinases encoded in the human gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34dd199e83e3ab8916756a48fb514e2
https://doi.org/10.1016/s0076-6879(06)14022-7
https://doi.org/10.1016/s0076-6879(06)14022-7