Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Debra Mcguinness"'
Autor:
Zhifeng Chen, Kara S. Cox, Aimin Tang, Jeanette Roman, Malorie Fink, Robin M. Kaufhold, Liming Guan, Andy Xie, Melissa A. Boddicker, Debra Mcguinness, Xiao Xiao, Hualin Li, Julie M. Skinner, Thorsten Verch, Mary Retzlaff, Kalpit A. Vora
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a protein conjugated p
Externí odkaz:
https://doaj.org/article/17579a56ee1d469c858501c0b85717c7
Autor:
Ellie Kim, Jian He, Robin M. Kaufhold, Debra McGuinness, Patrick McHugh, Denise Nawrocki, Jinfu Xie, Julie M. Skinner
Publikováno v:
Vaccine. 41:1774-1777
Autor:
Stephanie, Curry, Robin M, Kaufhold, Morgan A, Monslow, Yuhua, Zhang, Debra, McGuinness, Ellie, Kim, Denise K, Nawrocki, Patrick M, McHugh, Marie L, Briggs, William J, Smith, Jian, He, Joseph G, Joyce, Julie M, Skinner
Publikováno v:
Vaccine. 41:903-913
Despite the widespread effectiveness of pneumococcal conjugate vaccines on the overall incidence of invasive pneumococcal disease, the global epidemiological landscape continues to be transformed by residual disease from non-vaccine serotypes, thus h
Autor:
Luwy Musey, Yuhua Zhang, Cecilia Giovarelli, William J. Smith, Michael A. Winters, Jian He, Debra Mcguinness, Patrick Mchugh, Julie M. Skinner, Robin M. Kaufhold
Publikováno v:
Vaccine. 39:4231-4237
Invasive pneumococcal disease (IPD) is responsible for serious illnesses such as bacteremia, sepsis, meningitis, and pneumonia in young children, older adults, and persons with immunocompromising conditions and often leads to death. Although the most
Autor:
Han Wool Kim, Robert L. Burton, Hun Kim, Kyung Hyo Kim, Julie M. Skinner, Kun Young Ku, Sun Jin Kim, Moon H. Nahm, Jihye Seo, Seuk Keun Choi, Soyoung Lee, Jee hyun Seok, Jinfu Xie, Yeong Ok Baik, Sejong Bae, Debra Mcguinness
Publikováno v:
Vaccine
Pneumococcal conjugate vaccines (PCVs) have been effective in reducing the disease burden caused by Streptococcus pneumoniae. The first licensed PCV (PCV7) was composed of capsular polysaccharides from seven serotypes. This was followed by PCV10, the
Autor:
Terry Roemer, James R. Tata, Charles G. Garlisi, Mihirbaran Mandal, Christina B. Madsen-Duggan, Ginny D. Ho, Todd Mayhood, Jin Wu, Marc A. Labroli, John P. Caldwell, Alexei V. Buevich, Emma R. Parmee, Hao Wang, Jing Su, Paul Tawa, Sandra Koseoglu, Xiujuan Wen, Sang Ho Lee, Kallol Basu, Payal R. Sheth, Shu-Wei Yang, David G. McLaren, Haifeng Tang, Zheng Tan, Reynalda deJesus, Jenny Liu, Erika Walsh, Sookhee Ha, Christopher M. Tan, Li Xiao, Diane Rindgen, Amy M. Flattery, Debra Mcguinness, Christine Yang, Charles Gill, Paul L. Walsh, Lianzhu Liang
Publikováno v:
Journal of Medicinal Chemistry. 60:3851-3865
We describe our optimization efforts to improve the physicochemical properties, solubility, and off-target profile of 1, an inhibitor of TarO, an early stage enzyme in the biosynthetic pathway for wall teichoic acid (WTA) synthesis. Compound 1 displa
Autor:
Mary Retzlaff, Hualin Li, Robin M. Kaufhold, Xiao Xiao, Debra Mcguinness, Melissa A. Boddicker, Zhifeng Chen, Andy Xie, Julie M. Skinner, Kalpit A. Vora, Thorsten Verch, Liming Guan, Aimin Tang, Malorie Fink, Jeanette Roman, Kara S. Cox
Publikováno v:
BMC Infectious Diseases
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)
Background Community-acquired pneumonia is a leading infectious cause of hospitalization. A few vaccines exist to prevent pneumococcal disease in adults, including a pneumococcal polysaccharide unconjugated vaccine and a protein conjugated polysaccha
Autor:
John W. Phillips, Debra Mcguinness, Francisca Vicente, Charles Gill, John G. Ondeyka, Elizabeth Smith, Charles G. Garlisi, Robert G. K. Donald, Sheo B. Singh, Scott K. Smith, Angela Basilio, Jon D. Polishook, Gerald F. Bills, Deborah L. Zink, Michael A. Goetz, Hongchen Qiu
Publikováno v:
The Journal of Antibiotics. 67:527-531
The ever-increasing bacterial resistance to clinical antibiotics is making many drugs ineffective and creating significant treatment gaps. This can be only circumvented by the discovery of antibiotics with new mechanisms of action. We report here the
Autor:
Luwy Musey, Yuhua Zhang, William J. Smith, Jinfu Xie, Michael A. Winters, Robin M. Kaufhold, Cecelia Giovarelli, Julie M. Skinner, Debra Mcguinness, Kosinski Michael J
Publikováno v:
Open Forum Infectious Diseases
Background Streptococcus pneumoniae (pneumococcus) is a leading cause of a variety of diseases, including bacteremia, meningitis, and pneumonia, among older adults in the United States. Immunization with pneumococcal vaccines is an effective way to p
Autor:
Ying Zhai, Deborah Guyer, Liming Yu, Robert W. Bryant, Joseph Caravano, Jean Lachowicz, Leighton Howells, Tammy C. Turek-Etienne, Debra McGuinness
Publikováno v:
ASSAY and Drug Development Technologies. 2:290-299
Adenosine receptors belong to the superfamily of G protein-coupled receptors and are involved in a variety of physiologic functions. Traditionally, binding assays to detect adenosine 2a (A2a) antagonists and agonists have used filtration methods that