Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Debra L. Konkol"'
Autor:
Liyun Ding, Matthew P. Coghlan, Ellen P.S. Conceição Furber, Jorge Alsina-Fernandez, Kyle W. Sloop, Brian A. Droz, Mridula Dogra, Annie M. Long, Michael E. Christe, Tamer Coskun, Ruth E. Gimeno, Xiaoping Ruan, Jill A. Willency, William C. Roell, Debra L. Konkol, Adrienne K. Holland, Ricardo J. Samms, Jessica L. Friedrich, Libbey S. O’Farrell, Valentina Pirro, Over Cabrera, Daniel A. Briere, Richard Cosgrove, Samantha Wojnicki, Kyla A.L. Collins, Julie S. Moyers, Yanzhu Lin, Christine C. Cheng
Publikováno v:
J Clin Invest
Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control and weight loss compared with GLP-1R agonism in patients with type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4281cb2d7c4426d2de7cba245f46e9
https://doi.org/10.1172/jci146353
https://doi.org/10.1172/jci146353
Autor:
Andrew Ihor Korytko, J. Jacobs, Andrea E Sperry, John Michael Beals, Jessica L. Friedrich, Amy L. Cox, Steven D. Kahl, Eric D. Hawkins, Julie S. Moyers, Hana E. Baker, Ryan John Hansen, Volker Schellenberger, Chen Zhang, Michael E. Christe, M. Dodson Michael, Debra L. Konkol, D. Bruce Baldwin
Publikováno v:
Diabetes. 67
To optimize the action of exogenously administered insulin, we employed XTEN® technology to create insulins with variably sized XTEN amino acid polymers. Recombinant fusions of XTEN polymers linked to insulin lispro with an A21G mutation were prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e51120da1ca78912cf5dabd1af626da
https://doi.org/10.2337/db18-90-lb
https://doi.org/10.2337/db18-90-lb
Autor:
Debra L. Konkol, Kyle W. Sloop, M. Dodson Michael, Rohn Lee Millican, Michael E. Christe, Aaron D. Showalter, Eric D. Hawkins, Lucy S. Jun
Publikováno v:
Diabetes. 64(3)
The absence of insulin results in oscillating hyperglycemia and ketoacidosis in type 1 diabetes. Remarkably, mice genetically deficient in the glucagon receptor (Gcgr) are refractory to the pathophysiological symptoms of insulin deficiency, and there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadb72fc4a9818b74f91294249eb9aa2
https://pubmed.ncbi.nlm.nih.gov/25713199
https://pubmed.ncbi.nlm.nih.gov/25713199
Autor:
Robert M. Christie, Kenneth E. Gould, Craig J. Hartley, Sherita L. Daniel, Mark L. Entman, Damian F. Chaupin, Lloyd H. Michael, Debra L. Konkol, Jennifer Pocius, George E. Sandusky, Justin P. Zachariah, George E. Taffet
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 282(2)
Young mice tolerate myocardial loss after coronary artery ligation (CAL) without congestive heart failure (CHF) signs or mortality. We predicted a CHF phenotype after CAL in aged mice. Left coronary artery ligation produced permanent myocardial infar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417ba63103944e9e9c39c3f80b3be2f5
https://pubmed.ncbi.nlm.nih.gov/11788410
https://pubmed.ncbi.nlm.nih.gov/11788410
Autor:
Qingqin Li, Lawrence M. Gelbert, Debra L. Konkol, Kerry G. Bemis, Jian Wang, Yuke Zhang, Todd, Michael E. Christe, G. Cook, Ernst R. Dow, Lan Yu, Chad D. Geringer
Publikováno v:
Journal of Molecular and Cellular Cardiology. 34:A11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::707f9f263fc5720efd52bec68fc97d68
https://doi.org/10.1016/s0022-2828(02)90109-4
https://doi.org/10.1016/s0022-2828(02)90109-4