Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Debra L Sorensen"'
Autor:
Anna Majer, Sarah J Medina, Yulian Niu, Bernard Abrenica, Kathy J Manguiat, Kathy L Frost, Clark S Philipson, Debra L Sorensen, Stephanie A Booth
Publikováno v:
PLoS Pathogens, Vol 8, Iss 11, p e1003002 (2012)
Prion diseases typically have long pre-clinical incubation periods during which time the infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic sprouting and synaptic deficits are apparent during pre-clinical dis
Externí odkaz:
https://doaj.org/article/ce34b49876464f819464ee9a0224b8bd
Autor:
Debra L. Sorensen, Laura P. van Lieshout, James P. Bridges, Sarah K. Wootton, Ashley A. Stegelmeier, John J Lawder, Stephanie A. Booth, Tara N. Rindler, Kathy L. Frost
Publikováno v:
Gene Therapy. 30:236-244
Naturally occurring adeno-associated virus (AAV) serotypes that bind to ligands such as AVB sepharose or heparin can be purified by affinity chromatography, which is a more efficient and scalable method than gradient ultracentrifugation. Wild-type AA
Autor:
Debra L. Sorensen, Matthew J. Martin, Kathy L. Frost, Stephanie A. Booth, Kathy Manguiat, Sarah J. Medina, Anna Majer, Clark Phillipson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Multiple cell types and complex connection networks are an intrinsic feature of brain tissue. In this study we used expression profiling of specific microscopic regions of heterogeneous tissue sections isolated by laser capture microdissection (LCM)
Autor:
Tara N. Rindler, Kathy L. Frost, Jakob M. Domm, Sarah J. Medina, Stephanie A. Booth, James P. Bridges, Debra L. Sorensen, Laura P. van Lieshout, Sarah K. Wootton
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 323-329 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 323-329 (2018)
Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly used gene delivery vectors are those based on adeno-associated virus (AAV). Despite these
Autor:
Janna Kiselar, Sarah J. Medina, Jingjing Liang, Wei Wang, Serguei Ilchenko, Debra L. Sorensen, Witold K. Surewicz, Qingzhong Kong, Stephanie A. Booth
Publikováno v:
Journal of Biological Chemistry. 287:16510-16520
The ubiquitously expressed cellular prion protein (PrP(C)) is subjected to the physiological α-cleavage at a region critical for both PrP toxicity and the conversion of PrP(C) to its pathogenic prion form (PrP(Sc)), generating the C1 and N1 fragment
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Frontiers in Immunology
Frontiers in Immunology
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that can play critical roles as regulators of numerous pathways and biological processes including the immune response. Emerging as one of the most important miRNAs to orchestrate immun
Autor:
Clark S. Philipson, Kathy Manguiat, Kathy L. Frost, Anna Majer, Yulian Niu, Bernard Abrenica, Sarah J. Medina, Stephanie A. Booth, Debra L. Sorensen
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 8, Iss 11, p e1003002 (2012)
PLoS Pathogens, Vol 8, Iss 11, p e1003002 (2012)
Prion diseases typically have long pre-clinical incubation periods during which time the infectious prion particle and infectivity steadily propagate in the brain. Abnormal neuritic sprouting and synaptic deficits are apparent during pre-clinical dis
Autor:
Laura P. van Lieshout, Jakob M. Domm, Tara N. Rindler, Kathy L. Frost, Debra L. Sorensen, Sarah J. Medina, Stephanie A. Booth, James P. Bridges, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 323-329 (2018)
Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly used gene delivery vectors are those based on adeno-associated virus (AAV). Despite these
Externí odkaz:
https://doaj.org/article/2911c1cd90a04b1b9fa657f70797c3f5