Empirical, AI, and QSAR approaches to peptide-MHC binding prediction

Autor: Channa K. Hattotuwagama, Persephone Borrow, Valerie Walshe, Matthew Davies, Irini Doytchinova, Christopher P. Toseland, Darren R. Flower, Pingping Guan, Shelley L Hemsley, Debra J Taylor

Publikováno v: In Silico Immunology ISBN: 9780387392387

Immunoinformatics is facilitating important change within immunology and is helping it to engage more completely with the dynamic post-genomic revolution sweeping through bioscience. Historically, predicting the specificity of peptide Major Histocomp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd46a545ccf4df9d86231e48fc11560
https://doi.org/10.1007/978-0-387-39241-7_9

Toward Prediction of Class II Mouse Major Histocompatibility Complex Peptide Binding Affinity: in Silico Bioinformatic Evaluation Using Partial Least Squares, a Robust Multivariate Statistical Technique

Autor: Debra J. Taylor, Channa K. Hattotuwagama, Irini Doytchinova, Shelley L Hemsley, Christopher P. Toseland, Darren R. Flower, Pingping Guan

Publikováno v: Journal of Chemical Information and Modeling. 46:1491-1502

The accurate identification of T-cell epitopes remains a principal goal of bioinformatics within immunology. As the immunogenicity of peptide epitopes is dependent on their binding to major histocompatibility complex (MHC) molecules, the prediction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d4b54be4ecd24b4b7bd5f7505d95cc
https://doi.org/10.1021/ci050380d

Computational vaccinology: quantitative approaches

Autor: Persephone Borrow, Irini Doytchinova, Darren R. Flower, Valerie Walshe, Shouzhan Wan, Helen McSparron, Martin J Blythe, Christianna Zygouri, Peter V. Coveney, Pingping Guan, Debra J. Taylor

Publikováno v: Europe PubMed Central
Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function: Novartis Foundation Symposium 254

The immune system is hierarchical and has many levels, exhibiting much emergent behaviour. However, at its heart are molecular recognition events that are indistinguishable from other types of biomacromolecular interaction. These can be addressed wel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d1f9d6ef45d44a738ed5c64e020c4c
http://ora.ox.ac.uk/objects/uuid:013eb238-30d5-420a-bea1-8d7741a5c141