Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Debra J. Hazen-Martin"'
Autor:
Myra Haney Singleton, Arch G. Mainous, Wanda Taylor, Debra J. Hazen-Martin, Willette S. Burnham, Etta D. Pisano, Natalie Johnson, Deborah Deas, Leonie Gordon, J.G. Reves
Publikováno v:
Academic Medicine. 87:1548-1555
The Medical University of South Carolina launched a systematic plan to infuse diversity among its students, resident physicians, and faculty in 2002. The dean and stakeholders of the College of Medicine (COM) embraced the concept that a more populati
Autor:
Cungui Mao, Fenghe Liang, Zhijun Shen, Debra J. Hazen-Martin, Chunyan Qu, Bradley A. Schulte, Wei Hu
Publikováno v:
Molecular Brain Research. 125:40-46
Intracellular free Ca 2+ levels are critical to the activity of BK channels in inner ear type I spiral ligament fibrocytes. However, the mechanisms for regulating intracellular Ca 2+ levels in these cells are currently poorly understood. Using patch-
Publikováno v:
Hearing Research. 187:35-43
Recent experimental and clinical studies have provided considerable evidence to support the phenomenon of K(+) recycling in the mammalian cochlea. However, the precise cellular and molecular mechanisms underlying and regulating this process remain on
Autor:
Timothy J. Lyons, Leslie Eldridge, Mimi Sohn, Lyn Powell-Braxton, Samar M. Hammad, Debra J. Hazen-Martin, Wesley Won
Publikováno v:
Kidney and Blood Pressure Research. 26:351-361
Background/Aims: The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipopr
Autor:
Yasuo Okamoto, Lina M. Obeid, Yusuf A. Hannun, Hirofumi Sawai, Chiara Luberto, Daniel F. Hassler, Debra J. Hazen-Martin, Eric E. Boros, Paola Signorelli, Gary K. Smith
Publikováno v:
Journal of Biological Chemistry. 277:41128-41139
A high throughput screen for neutral, magnesium-dependent sphingomyelinase (SMase) was performed. One inhibitor discovered in the screen, GW4869, functioned as a noncompetitive inhibitor of the enzyme in vitro with an IC(50) of 1 microm. It did not i
Autor:
Jian Xing Ma, Rosalie K. Crouch, T. Michael Redmond, Debra J. Hazen-Martin, Martin Laser, Gian G. Re, Dongchang Zhang, Noel A. Brownlee
Publikováno v:
FEBS Letters. 452:199-204
The protein RPE65 has an important role in retinoid processing and/or retinoid transport in the eye. Retinoids are involved in cell differentiation, embryogenesis and carcinogenesis. Since the kidney is known as an important site for retinoid metabol
Autor:
Mark C. Willingham, Debra J. Hazen-Martin, A. Julian Garvin, Noel A. Brownlee, Reem El Bahtimi, Gian G. Re
Publikováno v:
International Journal of Cancer. 84:192-200
Anaplastic Wilms' tumors are commonly believed to be rare forms of progression, driven by p53 mutations, of the more common classical Wilms' tumor or nephroblastoma. Contrary to classical Wilms' tumors, anaplastic tumors traditionally tend to metasta
Autor:
Hironobu Sanada, Jing Xu, Peiying Yu, Robert M. Carey, John Phipps, David E. Bruns, Robin A. Felder, Pedro A. Jose, Debra J. Hazen-Martin
Publikováno v:
Hypertension. 33:1036-1042
Abstract —The ability of the dopamine-1 (D 1 )-like receptor to stimulate adenylyl cyclase (AC) and phospholipase C (PLC), inhibit sodium transport in the renal proximal tubule (RPT), and produce natriuresis is attenuated in several rat models of h
Autor:
Timothy S. Vincent, Gian G. Re, Debra J. Hazen-Martin, Betty I. Tarnowski, Mark C. Willingham, A. Julian Garvin
Publikováno v:
Pediatric Pathology & Laboratory Medicine. 16:777-789
Publikováno v:
Cancer Letters. 103:49-56
Suramin was found to affect the Wilms' tumor (WT) cell line, W13, by inhibiting in vitro growth (half-maximal inhibitory dose (ID50)=11 microM), insulin like growth factor II (IGF-II) cell binding (ID50 = 10 microM) and IGF-II induced DNA synthesis (