Výsledky vyhledávání - "Debra J. Beck"

Limited Sampling Strategy to Predict AUC of the CYP3A Phenotyping Probe Midazolam in Adults: Application to Various Assay Techniques

Autor: Debra J. Beck, Shirley M. Tsunoda, Daniel S Streetman, Angela D. M. Kashuba, Edna F. Choo, Grant R. Wilkinson, Jooran S. Kim, Anne N. Nafziger, Robert W. Kulawy, David J. Greenblatt, Joseph S. Bertino, Mario L. Rocci

Publikováno v: Journal of Clinical Pharmacology. 42:376-382

Midazolam clearance is used to phenotype hepatic CYP3A activity but requires multiple plasma samples following a single intravenous dose. The authors evaluated the use of a limited sampling scheme, using different assay techniques to determine the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78ac2d11d4d9efe0ae9ce1c2d74e620
https://doi.org/10.1177/0091270002424002

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Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping*

Autor: J. Steven Leeder, Debra J. Beck, Robert W. Kulawy, Russell Gotschall, Anne N. Nafziger, Joseph S. Bertino, Mario L. Rocci, Gregory L. Kearns, Angela D. M. Kashuba

Publikováno v: Clinical Pharmacology & Therapeutics. 64:257-268

Objective To determine the effect of 150 mg/day fluvoxamine on the activities of CYP1A2, CYP2D6, CYP3A, N-acetyltransferase-2 (NAT2), and xanthine oxidase (XO) by phenotyping with caffeine, dextromethorphan, and midazolam. Methods Oral caffeine (2 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0742c486e8977ffd6b6f49ba802653e7
https://doi.org/10.1016/s0009-9236(98)90174-6

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Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques

Autor: Jooran S, Kim, Anne N, Nafziger, Shirley M, Tsunoda, Edna E, Choo, Daniel S, Streetman, Angela D M, Kashuba, Robert W, Kulawy, Debra J, Beck, Mario L, Rocci, Grant R, Wilkinson, David J, Greenblatt, Joseph S, Bertino

Publikováno v: Journal of clinical pharmacology. 42(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::039669ed867a617dd9ade8f5b5fc1cc5
https://pubmed.ncbi.nlm.nih.gov/11936561

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Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam

Autor: Anne N. Nafziger, M. L. Rocci, Debra J. Beck, Joseph S. Bertino, Angela D. M. Kashuba, Robert W. Kulawy

Publikováno v: Clinical pharmacology and therapeutics. 64(3)

Objective Intraindividual variability and the effects of sex and menstrual cycle phase on CYP3A activity were evaluated by phenotyping with use of midazolam as the probe drug. Methods Midazolam (0.025 mg/kg) was administered intravenously to 10 white

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67df0ced022d43e8d377e3d2632062b
https://pubmed.ncbi.nlm.nih.gov/9757150

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Mass spectral investigations on trichothecene mycotoxins

Autor: Debra J. Beck, Thaiya Krishnamurthy, Robert K. Isensee, Bruce B. Jarvis

Publikováno v: Journal of Chromatography A. 469:209-222

Thermally labile, polar toxic roridins and biologically active, isomeric baccharinoids were separated on a reversed-phase high-performance liquid chromatography column and effectively ionized under thermospray ionization conditions. The mass spectra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84994b7f0410953e28544293149eabb2
https://doi.org/10.1016/s0021-9673(01)96456-8

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Mass spectral investigations on trichothecene mycotoxins. VIII--Thermospray ionization and collisionally activated dissociation of macrocyclic trichothecenes

Autor: Robert K. Isensee, Thaiya Krishnamurthy, Debra J. Beck

Publikováno v: Biomedicalenvironmental mass spectrometry. 18(5)

Several structurally similar, biologically active macrocyclic trichothecenes were ionized under thermospray conditions followed by collisionally activated dissociation of the ammonium adducts. Most of the observed daughter ions were formed by bond cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b839630b111ad5a718baf18882ed364
https://pubmed.ncbi.nlm.nih.gov/2752183

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