Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Debra J., Wallace"'
Publikováno v:
Organic Process Research & Development. 25:2288-2299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c2c309f427cb5afce5be16840e0efc
https://doi.org/10.1021/acs.oprd.1c00204
https://doi.org/10.1021/acs.oprd.1c00204
Autor:
Feiyue Wu, Adam J. Fine, Jungchul Kim, Feng Peng, Anna V. Jenks, Khateeta M. Emerson, Benjamin D. Sherry, Marco Euclide Armenante, Roman Kats-Kagan, Anil R. Ekkati, Feng Xu, Tetsuji Itoh, Andrew Brunskill, Zachary E. X. Dance, Zhijian Liu, Debra J. Wallace, Jacob H. Waldman, Jennifer V. Obligacion, Patrick S. Fier
Publikováno v:
Organic Process Research & Development. 25:2249-2259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18959ed2cbfceb5c2111d431508e88f5
https://doi.org/10.1021/acs.oprd.1c00149
https://doi.org/10.1021/acs.oprd.1c00149
Autor:
Benjamin D. Sherry, Nobuyoshi Yasuda, Mark Weisel, Yining Ji, Feng Xu, Debra J. Wallace, Jinchu Liu, Jianguo Yin, Zhijian Liu
Publikováno v:
Organic Process Research & Development. 22:273-277
Previous methods to prepare a bicyclic N-hydroxyl urea intermediate in the synthesis of the potent β-lactamase inhibitor relebactam were effective, but deemed unsuitable for long-term use. Therefore, we developed an in situ protection protocol durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c5bb8ae70b2df359c104f045b7ed527
https://doi.org/10.1021/acs.oprd.7b00381
https://doi.org/10.1021/acs.oprd.7b00381
Autor:
Melissa E. Howard, Andrew W. Gibson, Alejandro Dieguez-Vazquez, Debra J. Wallace, Artis Klapars, Robert D. Wilson, Jeremy P. Scott, Peter R. Mullens, Andrew D. Gibb, Carl A. Baxter, Jaemoon Lee, Sarah E. Brewer, Stephen P. Keen, Ed Cleator, Nadine Bremeyer, Anthony Alorati, Kevin R. Campos, Matthew L. Maddess, Joseph J. Lynch, Jing Li
Publikováno v:
Organic Process Research & Development. 18:528-538
The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10,11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdefbcc65171430752e7a0100c3ac289
https://doi.org/10.1021/op5000489
https://doi.org/10.1021/op5000489
Autor:
Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Debra J. Wallace, Ian Mangion, Paul Coleman, Seb Caille, John G. Allen, Xianglin Shi, William F. Kiesman, Donald G. Walker, Hidenori Takahashi, Alessandra Bartolozzi, Thomas Simpson, Keith Fandrick, Jason Mulder, Jean-Nicolas Desrosiers, Nitin Patel, Xingzhong Zeng, Daniel Fandrick, Carl A. Busacca, Jinhua J. Song, Chris H. Senanayake, Timothy P. Heffron, Andrew McClory, Andreas Stumpf, Jason D. Burch, Benjamin D. Sherry, Donald R. Gauthier, Louis-Charles Campeau, Jessica E. Reed, Jeff B. Smaill, Shu Yu, Olivier Dirat, Jed L. Hubbs, Nathan O. Fuller, Wesley F. Austin, Ruichao Shen, Brian S. Bronk, Gerald J. Tanoury, Stephen Eastham, Cristian L. Harrison, Benjamin J. Littler, Piero L. Ruggiero, Zhifeng Ye, Anne-Laure Grillo
Autor:
Sarah E. Brewer, Ed Cleator, Debra J. Wallace, Paulo Avalle, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Matthew M. Bio, Antony J. Davies, Gavin W. Stewart, Robert D. Wilson
Publikováno v:
Organic Process Research & Development. 17:1561-1567
The process development and multikilogram preparation of a TRPV1 antagonist, 1, is described. Pyrido[2,3-b]pyrazine 1 was prepared in a convergent manner by the coupling of two key fragments, glyoxal 2 and diamine 3. Glyoxal 2 was synthesized in six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55245a654caf02dc06470afc8eea876
https://doi.org/10.1021/op400304h
https://doi.org/10.1021/op400304h
Autor:
Debra J. Wallace, Robert A. Reamer
Publikováno v:
Tetrahedron Letters. 54:4425-4428
A new synthetic approach to the selective estrogen agonist 1 is described. The key steps in the route are a phosphine catalyzed 2+3 cycloaddition between an indanone enone and allenyl methyl ketone, and an unusual Robinson annulation to afford a bicy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d190bc1bb05d532ddcbd0a65c2aac6e
https://doi.org/10.1016/j.tetlet.2013.06.023
https://doi.org/10.1016/j.tetlet.2013.06.023
Publikováno v:
Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1 ISBN: 9780841231894
Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1
Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c56d2300d11af615d0827350eaa4bf6
https://doi.org/10.1021/bk-2016-1239.ch001
https://doi.org/10.1021/bk-2016-1239.ch001
Autor:
R. Scott Hoerrner, Juan D. Arredondo, C. Scott Shultz, Takahiro Itoh, Xianghui Wen, Debra J. Wallace, Jason L. Nyrop, Dalian Zhao, Paul G. Bulger, Daniel J. Muzzio, Lushi Tan, Ephraim M. Bassan, Qinghao Chen, Mark Weisel, Sarah J. Dolman, Chengfu Xie, Pintipa Grongsaard
Publikováno v:
Organic Process Research & Development. 16:1069-1081
The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317d3d594c7cd2a3aab48392e1bc47ab
https://doi.org/10.1021/op300031r
https://doi.org/10.1021/op300031r
Autor:
Debra J. Wallace, Paul D. O’Shea, Carmela Molinaro, Paul G. Bulger, Stephen Lau, Melissa E. Howard, Danny Gauvreau, Birgit Kosjek, Ernest E. Lee
Publikováno v:
The Journal of Organic Chemistry. 77:2299-2309
In this paper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process Chemistry group. The syntheses were initially designed as an enabling tool for Medicinal Chemistry colleagues in order to rapidly explore st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a169ae2009a6fd29d54586708b512e37
https://doi.org/10.1021/jo202620r
https://doi.org/10.1021/jo202620r