Výsledky vyhledávání - "Debra J Medway"

Akademický článek

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

Autor: Kiterie M E Faller, Debra J Medway, Dunja Aksentijevic, Liam Sebag-Montefiore, Jürgen E Schneider, Craig A Lygate, Stefan Neubauer

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66461 (2013)

Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy state. Rib

Externí odkaz: https://doaj.org/article/2099b823497449f68a437c195d518f2c

Zobrazit plný text záznamu

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis

Autor: Liam Sebag-Montefiore, Rebecca L. Cross, Tanmoy Ray, Philip J. Ostrowski, Natasha Sahgal, Stefan Neubauer, Craig A. Lygate, Debra J. Medway, Sevasti Zervou

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism

Creatine is important for energy metabolism, yet excitable cells such as cardiomyocytes do not synthesize creatine and rely on uptake via a specific membrane creatine transporter (CrT; SLC6A8). This process is tightly controlled with downregulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59c91d73b8665ee74a6f774a8e0048b
https://doi.org/10.1152/ajpendo.00637.2012

Zobrazit plný text záznamu

Living Without Creatine

Autor: Debra J. Medway, Imre Hunyor, Michiel ten Hove, Darci Phillips, Keith M. Channon, Stefan Neubauer, Dunja Aksentijevic, Dana Dawson, Kieran Clarke, Joseph de Bono, Robert S. Balaban, Sevasti Zervou, Liam Sebag-Montefiore, Craig A. Lygate, Hugh Watkins

Publikováno v: Europe PubMed Central

Rationale: Creatine is thought to be involved in the spatial and temporal buffering of ATP in energetic organs such as heart and skeletal muscle. Creatine depletion affects force generation during maximal stimulation, while reduced levels of myocardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277dc2e5e0d604bbabfb03613be78be0
https://doi.org/10.1161/circresaha.112.300725

Zobrazit plný text záznamu

Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period

Autor: Gary D. Lopaschuk, Dunja Aksentijevic, Gillian Douglas, Liam Sebag-Montefiore, Stefan Neubauer, Sevasti Zervou, Debra J. Medway, Craig A. Lygate

MCD inhibition shifts metabolism from fatty acid towards glucose oxidation, which has therapeutic potential for obesity and myocardial ischemic injury. However, ∼40% of patients with MCD deficiency develop cardiomyopathy during infancy. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3073fe39f4ea0fee148fb9fafcd626
https://ora.ox.ac.uk/objects/uuid:ea95eb4d-04a6-415d-ba19-95bff90325a5

Zobrazit plný text záznamu

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes

Autor: Sevasti Zervou, Jürgen E. Schneider, Hannah Barnes, Kimmo Makinen, Debra J. Medway, Craig A. Lygate, Dunja Aksentijevic, Liam Sebag-Montefiore, Stefan Neubauer

Aims To measure the activity of the key phosphotransfer enzymes creatine kinase (CK), adenylate kinase (AK), and glycolytic enzymes in two common mouse models of chronic heart failure. Methods and results C57BL/6 mice were subjected to transverse aor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ab5644d5830949fe6ca1cd728af5e1
https://doi.org/10.1093/eurjhf/hfq174

Zobrazit plný text záznamu

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart

Autor: Stefan Neubauer, Craig A. Lygate, Dunja Aksentijevic, Debra J. Medway, Kiterie M. E. Faller, Jürgen E. Schneider, Liam Sebag-Montefiore

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e66461 (2013)

Background: Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic\ud heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable\ud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a999b3b064570faec20816d5fc433d54
https://ora.ox.ac.uk/objects/uuid:f4601126-3769-4790-8e26-8ecb0bdd21a3

Zobrazit plný text záznamu

Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI

Autor: Hannah Barnes, Craig A. Lygate, Debra J. Medway, Jürgen E. Schneider, Jeanette Schulz-Menger, Stefan Neubauer, Lee Anne Stork, Steffen Bohl

Conventional methods to quantify infarct size after myocardial infarction in mice are not ideal, requiring either tissue destruction for histology or relying on nondirect measurements such as wall motion. We therefore implemented a fast, high-resolut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25161b1a5230ac9520b109cde670a09
https://ora.ox.ac.uk/objects/uuid:27a04520-9687-4d9f-ba43-2cf92e1e939d

Zobrazit plný text záznamu

Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla

Autor: Stefan Neubauer, Titus Lanz, Sean Smart, Lee Anne Stork, Debra J. Medway, Mark A. Griswold, Jürgen E. Schneider, Craig A. Lygate, Hannah Barnes

MRI can accurately and reproducibly assess cardiac function in rodents but requires relatively long imaging times. Therefore, parallel imaging techniques using a 4-element RF-coil array and MR sequences for cardiac MRI in rats were implemented at ult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f653630998eedd5dc460421e6aa5df04
https://doi.org/10.1002/mrm.21491

Zobrazit plný text záznamu

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

Autor: Stefan Neubauer, Philip J. Ostrowski, Debra J. Medway, Imre Hunyor, Dunja Aksentijevic, Liam Sebag-Montefiore, Sevasti Zervou, Jürgen E. Schneider, Craig A. Lygate

Publikováno v: Basic Research in Cardiology

The creatine kinase (CK) energy transport and buffering system supports cardiac function at times of high demand and is impaired in the failing heart. Mice deficient in muscle- and mitochondrial-CK (M/Mt-CK−/−) have previously been described, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72d4027a24e80bde91ad843c436ecf7
https://ora.ox.ac.uk/objects/uuid:7560fc3a-0d3e-4b84-b765-943f4f41e4ae

Zobrazit plný text záznamu

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart

Autor: Steffen Bohl, Debra J. Medway, Craig A. Lygate, Jürgen E. Schneider, Stefan Neubauer, Jeanette Schulz-Menger

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology

Cardiac ischemia-reperfusion experiments in the mouse are important in vivo models of human disease. Infarct size is a particularly important scientific readout as virtually all cardiocirculatory pathways are affected by it. Therefore, such measureme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e9cb1269233e8e251ebc38882eabc5
http://europepmc.org/articles/PMC2793132

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání