Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Debra H. Josephs"'
Autor:
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. Veal, Christopher J. Corrigan, Stephen J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. Bax, Debra H. Josephs, Sophia N. Karagiannis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT025
Externí odkaz:
https://doaj.org/article/10c6fe5134614037a52da348794ee12d
Autor:
Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec
Externí odkaz:
https://doaj.org/article/eeac938a111045e186e031edbfe48da6
Autor:
Aida Santaolalla, Sam Sollie, Ali Rislan, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Sophia N. Karagiannis, Mieke Van Hemelrijck
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explored the reciprocity bet
Externí odkaz:
https://doaj.org/article/a45e755c665e4ded82f5f3b610ad4bf7
Autor:
Sam Sollie, Dominique S. Michaud, Debashis Sarker, Sophia N. Karagiannis, Debra H. Josephs, Niklas Hammar, Aida Santaolalla, Goran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner, Mieke Van Hemelrijck
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-6 (2019)
Abstract Background Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no associations. In this
Externí odkaz:
https://doaj.org/article/95514ac8a65345dd96aff8e2d85e930e
Autor:
Giulia Pellizzari, Coran Hoskin, Silvia Crescioli, Silvia Mele, Jelena Gotovina, Giulia Chiaruttini, Rodolfo Bianchini, Kristina Ilieva, Heather J. Bax, Sophie Papa, Katie E. Lacy, Erika Jensen-Jarolim, Sophia Tsoka, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 67-81 (2019)
Background: Antibody Fc-driven engagement of macrophages is critical for evoking cellular activation and effector functions and influencing tumour-associated macrophage (TAM) recruitment. We previously reported that IgE class antibodies promote restr
Externí odkaz:
https://doaj.org/article/134f820ecc8b45c6a2a8f7c4c9cb338c
Autor:
Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o
Externí odkaz:
https://doaj.org/article/59a0d8fd7d8e4872844a46ea0fa1a73b
Autor:
Jitesh Chauhan, Chara Stavraka, Melanie Grandits, Lais C. G. F. Palhares, Debra H. Josephs, Katie E. Lacy, James Spicer, Heather J. Bax, Sophia N. Karagiannis
Publikováno v:
Cells, Vol 11, Iss 3, p 438 (2022)
Despite comprising a very small proportion of circulating blood leukocytes, basophils are potent immune effector cells. The high-affinity receptor for IgE (FcɛRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as
Externí odkaz:
https://doaj.org/article/fe3f07ce92bb4050b96a67c7b3dbf11d
Autor:
Sam Sollie, Aida Santaolalla, Dominique S. Michaud, Debashis Sarker, Sophia N. Karagiannis, Debra H. Josephs, Niklas Hammar, Goran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner, Mieke Van Hemelrijck
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Emerging evidence points to potential roles of the humoral immune responses in the development of pancreatic cancer. Epidemiological studies have suggested involvement of viral and bacterial infections in pancreatic carcinogenesis. Experi
Externí odkaz:
https://doaj.org/article/5b2f6ae33eb941f0ad520a02a65d41db
Autor:
Iwan P. Williams, Silvia Crescioli, Heng Sheng Sow, Heather J. Bax, Carl Hobbs, Kristina M. Ilieva, Elise French, Giulia Pellizzari, Vivienne Cox, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis, Silvia Mele
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
IgE monoclonal antibodies hold great potential for cancer therapy. Preclinical in vivo systems, particularly those in which the antibody recognizes the host species target antigen and binds to cognate Fc receptors, are often the closest approximation
Externí odkaz:
https://doaj.org/article/6ff446d9996240a9913b11d5fd13c531
Autor:
Alex J. McCraw, Jitesh Chauhan, Heather J. Bax, Chara Stavraka, Gabriel Osborn, Melanie Grandits, Jacobo López-Abente, Debra H. Josephs, James Spicer, Gerd K. Wagner, Sophia N. Karagiannis, Alicia Chenoweth, Silvia Crescioli
Publikováno v:
Cancers, Vol 13, Iss 17, p 4460 (2021)
IgE, the predominant antibody class of the allergic response, is known for its roles in protecting against parasites; however, a growing body of evidence indicates a significant role for IgE and its associated effector cells in tumour immunosurveilla
Externí odkaz:
https://doaj.org/article/d8adef8b85f0406e9f1bae8b64b3fe54