Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Debra E. Rugowski"'
Autor:
Debra E. Rugowski, Jorge F Guerrero, Suzanne M. Ponik, Fatou Jallow, Linda A. Schuler, Kathleen A. O'Leary
Publikováno v:
Oncogene
Metastatic, anti-estrogen resistant estrogen receptor α positive (ER+) breast cancer is the leading cause of breast cancer deaths in U.S. women. While studies have demonstrated the importance of the stromal tumor microenvironment in cancer progressi
Autor:
Hatim T. Allawi, Slava Katerov, Abram Vaccaro, Harrison L. Fleming, Debra E. Rugowski, Brittany Otto, Justin Heilberger, Jillian Cassel, Jacquelyn Hennek, William Taylor, Graham Lidgard
Publikováno v:
Cancer Research. 82:631-631
Purpose: Many cancer deaths could be avoided, and survival could be improved with detection of cancer at an earlier stage. Screening programs for breast, colon, and cervical cancer as well as the NLST trial for lung cancer screening demonstrated sign
Autor:
Linda A. Schuler, Debra E. Rugowski, Ruth Sullivan, Michael P. Shea, Kathleen A. O'Leary, Amy R. Moser
Publikováno v:
Cancer Lett
Prolactin (PRL) cooperates with other factors to orchestrate mammary development and lactation, and is epidemiologically linked to higher risk for breast cancer. However, how PRL collaborates with oncogenes to foster tumorigenesis and influence breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0a32e9696980071fedd2010520f542
https://europepmc.org/articles/PMC7995738/
https://europepmc.org/articles/PMC7995738/
Autor:
Debra E. Rugowski, Elaine T. Alarid, Jennifer L. Brockman, Kyle T Helzer, Fatou Jallow, Vincent Goffin, Linda A. Schuler
Publikováno v:
Journal of the Endocrine Society
Prolactin (PRL) and estrogen cooperate in lobuloalveolar development of the mammary gland and jointly regulate gene expression in breast cancer cells in vitro. Canonical PRL signaling activates STAT5A/B, homologous proteins that have different target
Autor:
Kilannin Krysiak, Malachi Griffith, Kathleen A. O'Leary, Obi L. Griffith, Zachary L. Skidmore, Katie M. Campbell, Erica K. Barnell, Debra E. Rugowski, Linda A. Schuler, William A. Mulligan
SummaryThe NRL-PRL murine model, defined by mammary-selective transgenic rat prolactin ligand rPrl expression, establishes spontaneous ER+ mammary tumors, mimicking the association between elevated prolactin (PRL) and risk for development of ER+ brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b0c10857856dbc0d58171139657b4c
https://doi.org/10.1101/442624
https://doi.org/10.1101/442624
Autor:
Erica K. Barnell, Katie M. Campbell, Obi L. Griffith, William A. Mulligan, Linda A. Schuler, Debra E. Rugowski, Zachary L. Skidmore, Kilannin Krysiak, Malachi Griffith, Kathleen A. O'Leary
Publikováno v:
Cell Reports. 28:1526-1537.e4
The NRL-PRL murine model, defined by mammary-selective transgenic rat prolactin ligand rPrl expression, establishes spontaneous ER+ mammary tumors in nulliparous females, mimicking the association between elevated prolactin (PRL) and risk for develop
Autor:
Linda A. Schuler, Debra E. Rugowski, Ruth Sullivan, Kathleen A. O'Leary, Fatou Jallow, Kerstin W. Sinkevicius, Geoffrey L. Greene
Publikováno v:
Endocrinology. 154:4483-4492
Resistance of estrogen receptor positive (ERα+) breast cancers to antiestrogens is a major factor in the mortality of this disease. Although activation of ERα in the absence of ligand is hypothesized to contribute to this resistance, the potency of
Autor:
Malachi Griffith, Kathleen A. O'Leary, Katie M. Campbell, Kilannin Krysiak, Debra E. Rugowski, Obi L. Griffith, Linda A. Schuler, William A. Mulligan
Publikováno v:
Cancer Research. 78:5104-5104
Metastatic therapy-resistant breast cancers expressing estrogen receptor alpha (ER+) account for the majority of breast cancer deaths. Understanding of the underlying biology of aggressive luminal B cancers would improve preventive/treatment strategi
Autor:
Hallgeir Rui, Lisa M. Arendt, Debra E. Rugowski, Linda A. Schuler, Maria Jose Garcia-Barchino, Lindsay C Evans
Publikováno v:
Journal of Endocrinology. 203:99-110
Epidemiologic studies have demonstrated that increased prolactin (PRL) exposure raises the risk of invasive estrogen receptor α (ERα)-positive breast cancer in women. However, the mechanism(s) whereby this occurs and the interactions with estrogen
Publikováno v:
Molecular Endocrinology. 19:1765-1778
Despite the important roles of both prolactin (PRL) and 17beta-estradiol (E2) in normal mammary development as well as in breast cancer, and coexpression of the estrogen receptor (ER) and PRL receptor in many mammary tumors, the interactions between